In recent years, the incidence of refractory Mycoplasma pneumoniae pneumonia (RMPP) has significantly risen, posing severe pulmonary and extrapulmonary complications, making early identification a challenge for clinicians. In this retrospective singl...
BACKGROUND: Pharmaceutical residual such as antibiotics and disinfectants in aquaculture wastewater have significant potential risks for environment and human health. Surface enhanced Raman spectroscopy (SERS) has been widely used for the detection o...
Environmental pollution (Barking, Essex : 1987)
May 15, 2025
The rapid and accurate identification of antibiotics in environmental samples is critical for addressing the growing concern of antibiotic pollution, particularly in water sources. Antibiotic contamination poses a significant risk to ecosystems and h...
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
May 15, 2025
Accurate therapeutic drug monitoring (TDM) of antibiotics including ceftriaxone, ampicillin, and vancomycin plays an important role in the treatment of neonatal sepsis, a common and life-threatening disease in neonates. A highly sensitive surface-enh...
BACKGROUND: Early identification of children at risk of sepsis in emergency departments (EDs) is crucial for timely treatment and improved outcomes. Existing risk scores and criteria for paediatric sepsis are not well-suited for early diagnosis in ED...
Carbapenem resistance and hypervirulence represent two distinct evolutionary pathways in , posing significant challenges in clinical settings. Of particular concern are convergent strains that combine both traits, complicating timely diagnosis and tr...
The Journal of antimicrobial chemotherapy
May 2, 2025
INTRODUCTION: Large language models (LLMs) are becoming ubiquitous and widely implemented. LLMs could also be used for diagnosis and treatment. National antibiotic prescribing guidelines are customized and informed by local laboratory data on antimic...
Infectious diseases caused by pathogens resistant to antimicrobial treatments, defined as antimicrobial resistance (AMR), are a serious global health crisis, considered among the main threats to global public health according to the World Health Orga...
The bacterial cell wall is crucial for maintaining the integrity of bacterial cells. UDP-N-acetylglucosamine 1-carboxyethylene transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. Therefore, it is an important target f...
Antimicrobial peptides (AMPs) face stability and toxicity challenges in clinical use. Stapled modification enhances their stability and effectiveness, but its application in peptide design is rarely reported. This study built ten prediction models fo...
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