AIMC Topic: Anti-Inflammatory Agents
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Screening Anti-inflammatory, Anticoagulant, and Respiratory Agents for SARS-CoV-2 3CL Inhibition from Chemical Fingerprints Through a Deep Learning Approach.
Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion
Jan 3, 2022
BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of coronavirus disease 2019 (COVID-19), triggers a pathophysiological process linked not only to viral mechanisms of infectivity, but also to the pattern of...
Pharmacokinetics of panduratin A following oral administration of a Boesenbergia pandurata extract to rats.
Journal of food and drug analysis
Dec 15, 2021
Boesenbergia pandurata and its major active ingredient, panduratin A (PAN), exhibit antibacterial, anti-oxidant, anti-inflammatory, and anti-obesity effects. We explored the time course of the plasma and tissue (in the major organs, gums and skin) co...
Discovery of Pyrazolo[3,4-]pyridazinone Derivatives as Selective DDR1 Inhibitors via Deep Learning Based Design, Synthesis, and Biological Evaluation.
Journal of medicinal chemistry
Nov 25, 2021
Alterations of discoidin domain receptor1 (DDR1) may lead to increased production of inflammatory cytokines, making DDR1 an attractive target for inflammatory bowel disease (IBD) therapy. A scaffold-based molecular design workflow was established and...
AIEpred: An Ensemble Predictive Model of Classifier Chain to Identify Anti-Inflammatory Peptides.
IEEE/ACM transactions on computational biology and bioinformatics
Oct 7, 2021
Anti-inflammatory peptides (AIEs) have recently emerged as promising therapeutic agent for treatment of various inflammatory diseases, such as rheumatoid arthritis and Alzheimer's disease. Therefore, detecting the correlation between amino acid seque...
Expanding the drug discovery space with predicted metabolite-target interactions.
Communications biology
Mar 5, 2021
Metabolites produced in the human gut are known modulators of host immunity. However, large-scale identification of metabolite-host receptor interactions remains a daunting challenge. Here, we employed computational approaches to identify 983 potenti...
Signal Transduction
Gastrointestinal Microbiome
Metabolomics
Metabolome
Gene Expression Profiling
Transcriptome
Protein Interaction Maps
Bacteria
Molecular Targeted Therapy
Host-Pathogen Interactions
Anti-Inflammatory Agents
Gastrointestinal Agents
Data Mining
Ligands
Humans
Machine Learning
Cells, Cultured
Databases, Factual
Inflammatory Bowel Diseases
Drug Discovery
Virgin Coconut Oil-Induced Neuroprotection in Lipopolysaccharide-Challenged Rats is Mediated, in Part, Through Cholinergic, Anti-Oxidative and Anti-Inflammatory Pathways.
Journal of dietary supplements
Oct 14, 2020
Neuroinflammation is associated with neuronal cell death and could lead to chronic neurodegeneration. This study investigated the neuroprotective potential of virgin coconut oil (VCO) against lipopolysaccharide (LPS)-induced cytotoxicity of neuroblas...
Label-Free Quantification of Pharmacokinetics in Skin with Stimulated Raman Scattering Microscopy and Deep Learning.
The Journal of investigative dermatology
Jul 22, 2020
The treatment of inflammatory skin conditions relies on a deep understanding of how drugs and tissue behave and interact. Although numerous methods have been developed that aim to follow and quantify topical drug pharmacokinetics, these tools can com...
Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment.
Drug design, development and therapy
Feb 20, 2020
BACKGROUND: Sanjie Zhentong capsule (SZC) offers excellent effect in treating adenomyosis (AM), which is a common and difficult gynecological disease in the clinic. However, the systematic analysis of its mechanism has not been carried out yet and fu...
Alkaline conditions better extract anti-inflammatory polysaccharides from winemaking by-products.
Food research international (Ottawa, Ont.)
Jul 3, 2019
Winemaking generates large amounts of by-products, a well recognized source of phenolic compounds. However, less attention has been paid to the polysaccharide-rich fraction (PRF) and effects of fractionation techniques on its potential bioactivity. T...
The Effect of the Prethanol Extract of Trifolium pratense Leaves on Interleukin-1β-Induced Cartilage Matrix Degradation in Primary Rat Chondrocytes.
Cells, tissues, organs
Jan 31, 2019
BACKGROUND: Osteoarthritis (OA) is a degenerative joint disease, characterized by cartilage degradation and inflammation. The proinflammatory cytokine, interleukin (IL)-1β, plays a crucial role in the pathogenesis of OA by inducing the release of oth...
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