AIMC Topic: Anticoagulants

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Continuous Infusion Low-Dose Unfractionated Heparin for the Management of Hypercoagulability Associated With COVID-19.

Journal of pharmacy practice Oct 14, 2020
INTRODUCTION: The Coronavirus Disease 2019 (COVID-19) is associated with severe hypercoagulability. There is currently limited evidence supporting the routine use of therapeutic anticoagulation in the setting of COVID-19.
COVID-19 Drug Treatment Anticoagulants Humans Thrombosis Retrospective Studies Hemorrhage Adult Thrombophilia Heparin Venous Thromboembolism
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Risks and complications of robot-assisted radical prostatectomy (RARP) in patients receiving antiplatelet and/or anticoagulant therapy: a retrospective cohort study in a single institute.

Journal of robotic surgery Oct 12, 2020
The objective of the study was to evaluate the risk of bleeding complications in patients undergoing robot-assisted radical prostatectomy (RARP) while taking antiplatelet (AP) and/or anticoagulant (AC) agents. We analyzed the data of 334 patients und...
Humans Retrospective Studies Prostatic Neoplasms Robotic Surgical Procedures Postoperative Hemorrhage Platelet Aggregation Inhibitors Prostatectomy Male Postoperative Complications Treatment Outcome Robotics Anticoagulants
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Sulodexide modulates the dialysate effect on the peritoneal mesothelium.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society Mar 20, 2020
Peritoneal membrane damage during chronic peritoneal dialysis is the main cause of that treatment failure. Preservation of the mesothelial cells (MC) is important for the survival of the peritoneum. Evaluation of dialysates effect on the function of ...
Humans Peritoneal Dialysis, Continuous Ambulatory Cells, Cultured Peritoneum Anticoagulants Oxidative Stress Dialysis Solutions Epithelium Glycosaminoglycans Gene Expression Regulation
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[Predicting atrial fibrillation through a sinus-rhythm electrocardiogram; useful or not?].

Nederlands tijdschrift voor geneeskunde Nov 28, 2019
In patients with cryptogenic stroke, the detection of atrial fibrillation (AF) is important, since it is an indication for the prescription of oral anticoagulation, instead of anti-platelet therapy, to decrease the chance of a recurrent ischaemic cer...
Algorithms Decision Support Techniques Reproducibility of Results Electrocardiography Anticoagulants Predictive Value of Tests Humans Artificial Intelligence Stroke Atrial Fibrillation
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Factor Xa inhibitors in clinical practice: Comparison of pharmacokinetic profiles.

Drug metabolism and pharmacokinetics Oct 25, 2019
BACKGROUND: The anticoagulant actions of oral direct factor Xa (FXa) inhibitors can be inferred from their observed plasma concentrations; however, the steady-state pharmacokinetics (PK) of different FXa inhibitors have not been compared in clinicall...
Factor Xa Inhibitors Prospective Studies Pyrazoles Female Rivaroxaban Humans Aged Atrial Fibrillation Male Pyridones Venous Thromboembolism Chromatography, Liquid Thiazoles Pyridines Blood Coagulation Tests Anticoagulants Factor Xa Tandem Mass Spectrometry
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Ensemble of machine learning algorithms using the stacked generalization approach to estimate the warfarin dose.

PloS one Oct 19, 2018
Warfarin dosing remains challenging due to narrow therapeutic index and highly individual variability. Incorrect warfarin dosing is associated with devastating adverse events. Remarkable efforts have been made to develop the machine learning based wa...
Humans Machine Learning Aged, 80 and over Male Middle Aged Pharmacogenetics Cohort Studies Algorithms Databases, Factual Female Aged Thrombosis Linkage Disequilibrium Hemorrhage Polymorphism, Single Nucleotide Medical Errors Drug Administration Schedule Genotype Vitamin K Epoxide Reductases Multivariate Analysis Anticoagulants International Cooperation Warfarin
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A prediction study of warfarin individual stable dose after mechanical heart valve replacement: adaptive neural-fuzzy inference system prediction.

BMC surgery Feb 15, 2018
BACKGROUND: It's difficult but urgent to achieve the individualized rational medication of the warfarin, we aim to predict the individualized warfarin stable dose though the artificial intelligent Adaptive neural-fuzzy inference system (ANFIS).
Warfarin Heart Valve Prosthesis Implantation Linear Models Middle Aged China Fuzzy Logic Anticoagulants Humans Neural Networks, Computer Retrospective Studies Female Reproducibility of Results Male
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A Comparative Study of Point-of-Care Prothrombin Time in Cardiopulmonary Bypass Surgery.

Journal of cardiothoracic and vascular anesthesia Dec 29, 2017
OBJECTIVE: Point-of-care (POC) devices allow for prothrombin time/international normalized ratio (PT/INR) testing in whole blood (WB) and timely administration of plasma or prothrombin complex concentrate during cardiopulmonary bypass surgery. This s...
Humans Prospective Studies Female Young Adult Adult Male Warfarin International Normalized Ratio Cardiopulmonary Bypass Prothrombin Time Point-of-Care Systems Middle Aged Monitoring, Intraoperative Anticoagulants
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Using Artificial Intelligence to Reduce the Risk of Nonadherence in Patients on Anticoagulation Therapy.

Stroke Apr 6, 2017
BACKGROUND AND PURPOSE: This study evaluated the use of an artificial intelligence platform on mobile devices in measuring and increasing medication adherence in stroke patients on anticoagulation therapy. The introduction of direct oral anticoagulan...
Brain Ischemia Patient Outcome Assessment Medical Informatics Applications Medication Adherence Mobile Applications Anticoagulants Stroke Humans Artificial Intelligence Female Aged Adult Male Middle Aged
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Bone Wax Is Effective in Reducing Blood Loss After Total Knee Arthroplasty.

The Journal of arthroplasty Dec 24, 2016
BACKGROUND: Total knee arthroplasty (TKA) is associated with major blood loss and blood transfusion is often required. This study aimed to evaluate the efficacy of bone wax in reducing blood loss and transfusion rates after TKA.
Tourniquets Waxes Prospective Studies Female Arthroplasty, Replacement, Knee Aged Blood Transfusion Bone Cements Aged, 80 and over Anticoagulants Palmitates Male Electrocoagulation Middle Aged Humans Hemostasis Treatment Outcome Body Mass Index Blood Loss, Surgical Postoperative Hemorrhage Hemoglobins
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