AIMC Topic: Antineoplastic Agents
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Enhancing targeted tumor treatment: A novel fuzzy logic framework for precision drug delivery strategy selection.
Computers in biology and medicine
Aug 14, 2024
OBJECTIVE: This study aims to address the challenge of selecting optimal drug delivery strategies for tumor patients by introducing a novel theoretical framework.
Rapid Identification of Drug Mechanisms with Deep Learning-Based Multichannel Surface-Enhanced Raman Spectroscopy.
ACS sensors
Aug 13, 2024
Rapid identification of drug mechanisms is vital to the development and effective use of chemotherapeutics. Herein, we develop a multichannel surface-enhanced Raman scattering (SERS) sensor array and apply deep learning approaches to realize the rapi...
SAFER: sub-hypergraph attention-based neural network for predicting effective responses to dose combinations.
BMC bioinformatics
Jul 30, 2024
BACKGROUND: The potential benefits of drug combination synergy in cancer medicine are significant, yet the risks must be carefully managed due to the possibility of increased toxicity. Although artificial intelligence applications have demonstrated n...
Extended dipeptide composition framework for accurate identification of anticancer peptides.
Scientific reports
Jul 29, 2024
The identification of anticancer peptides (ACPs) is crucial, especially in the development of peptide-based cancer therapy. The classical models such as Split Amino Acid Composition (SAAC) and Pseudo Amino Acid Composition (PseAAC) lack the incorpora...
DeepDRA: Drug repurposing using multi-omics data integration with autoencoders.
PloS one
Jul 26, 2024
Cancer treatment has become one of the biggest challenges in the world today. Different treatments are used against cancer; drug-based treatments have shown better results. On the other hand, designing new drugs for cancer is costly and time-consumin...
Artificial intelligence-derived left ventricular strain in echocardiography in patients treated with chemotherapy.
The international journal of cardiovascular imaging
Jul 23, 2024
Global longitudinal strain (GLS) is an echocardiographic measure to detect chemotherapy-related cardiovascular dysfunction. However, its limited availability and the needed expertise may restrict its generalization. Artificial intelligence (AI)-based...
Cardiotoxicity
Ventricular Dysfunction, Left
Image Interpretation, Computer-Assisted
Humans
Observer Variation
Artificial Intelligence
Retrospective Studies
Female
Echocardiography
Reproducibility of Results
Heart Ventricles
Middle Aged
Male
Aged
Antineoplastic Agents
Ventricular Function, Left
Ventricular Remodeling
Neoplasms
Aged, 80 and over
Predictive Value of Tests
Stroke Volume
PLMACPred prediction of anticancer peptides based on protein language model and wavelet denoising transformation.
Scientific reports
Jul 23, 2024
Anticancer peptides (ACPs) perform a promising role in discovering anti-cancer drugs. The growing research on ACPs as therapeutic agent is increasing due to its minimal side effects. However, identifying novel ACPs using wet-lab experiments are gener...
Neurological insights into brain-targeted cancer therapy and bioinspired microrobots.
Drug discovery today
Jul 17, 2024
Cancer, a multifaceted and pernicious disease, continuously challenges medicine, requiring innovative treatments. Brain cancers pose unique and daunting challenges due to the intricacies of the central nervous system and the blood-brain barrier. In t...
Molecular docking aided machine learning for the identification of potential VEGFR inhibitors against renal cell carcinoma.
Medical oncology (Northwood, London, England)
Jul 9, 2024
Renal cell carcinoma is a highly vascular tumor associated with vascular endothelial growth factor (VEGF) expression. The Vascular Endothelial Growth Factor -2 (VEGF-2) and its receptor was identified as a potential anti-cancer target, and it plays a...
Interpretable artificial intelligence to optimise use of imatinib after resection in patients with localised gastrointestinal stromal tumours: an observational cohort study.
The Lancet. Oncology
Jul 5, 2024
BACKGROUND: Current guidelines recommend use of adjuvant imatinib therapy for many patients with gastrointestinal stromal tumours (GISTs); however, its optimal treatment duration is unknown and some patient groups do not benefit from the therapy. We ...
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