Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
Sep 26, 2025
PURPOSE: This study aimed to analyze the influencing factors of moderate-to-severe cancer-related fatigue (CRF) in colorectal cancer (CRC) chemotherapy patients and to develop a predictive risk stratification model.
Messenger RNA (mRNA) therapeutics hold significant potential across a wide range of medical applications. LNPs are the most clinically advanced mRNA delivery vehicles, but challenges such as off-target effects and liver accumulation limit their broad...
Ovarian cancer is a global silent killer in women and is the second most common cause of gynecologic cancer-related deaths. Despite significant research and advances in treatment, ovarian cancer treatment remains a challenge, as it is diagnosed in an...
Journal of chemical information and modeling
Sep 22, 2025
Cancer remains a major threat to human health. Tumor heterogeneity often leads to differences in tumor growth rate, invasion capacity, drug sensitivity, and prognosis, which complicates treatment strategies. Currently, drug responses are often verifi...
Liver cancer, particularly hepatocellular carcinoma (HCC), remains a significant health burden with poor survival rates due to late diagnosis and limited treatment options. Sorafenib, a multi-kinase inhibitor, is the standard first-line therapy for a...
To address the toxicity of current microtubule inhibitors, we employed the GeminiMol deep learning model to screen the Zinc20 database, identifying a novel 4,5-dihydropyrrolo[3,4-]pyrazol-6(2)-one scaffold () targeting the colchicine binding site. Su...
Colorectal cancer is one of the leading causes of cancer-related deaths worldwide, mainly due to aberrant Wnt/β-catenin signaling resulting from APC mutations. Tankyrase is a key regulator of this pathway and plays a crucial role in stabilizing AXIN,...
European journal of medicinal chemistry
Sep 17, 2025
Developing optimized AI models for virtual screening requires coordinated selection of algorithms, molecular representations, and data splitting strategies, yet lacks integrated tools. We present PyaiVS, a Python package that integrates nine machine ...
Journal of chemical information and modeling
Sep 16, 2025
Combination therapy presents a transformative approach to treating complex diseases such as cancer by mitigating toxicity and resistance challenges inherent to monotherapy. A critical gap in current computational methods, however, lies in their inabi...
Artificial intelligence (AI) has the potential to transform nanoparticle development for drug delivery; however, existing strategies typically optimize either material selection or component ratios in isolation. To enable simultaneous optimization of...
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