AIMC Topic: Antiviral Agents

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Predicting antimicrobial peptides with improved accuracy by incorporating the compositional, physico-chemical and structural features into Chou's general PseAAC.

Scientific reports Feb 13, 2017
Antimicrobial peptides (AMPs) are important components of the innate immune system that have been found to be effective against disease causing pathogens. Identification of AMPs through wet-lab experiment is expensive. Therefore, development of effic...
Databases, Protein Antimicrobial Cationic Peptides Area Under Curve Antifungal Agents Chemical Phenomena ROC Curve Antiviral Agents Support Vector Machine
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PHENOLIC PROFILE OF L. GROWING IN EGYPT AND ITS CYTOTOXIC AND ANTIVIRAL ACTIVITIES.

African journal of traditional, complementary, and alternative medicines : AJTCAM Sep 29, 2016
BACKGROUND: L (Asteraceae), is one of the most attractive plants growing wildly in Sinai, and is not well investigated for its phytochemical constituents. This study represents the first in-depth characterization of the phenolic profile of the aeria...
HCT116 Cells Phenols Humans Antiviral Agents Plant Extracts Hep G2 Cells Antineoplastic Agents, Phytogenic Plant Components, Aerial Centaurea MCF-7 Cells Egypt Tandem Mass Spectrometry HeLa Cells
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Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of patients with HBeAg-negative chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial.

The lancet. Gastroenterology & hepatology Sep 22, 2016
BACKGROUND: The novel prodrug tenofovir alafenamide delivers the nucleotide reverse transcriptase inhibitor tenofovir to target cells more efficiently at a lower dose than tenofovir disoproxil fumarate, thereby reducing systemic exposure. We compared...
Adenine Alanine Follow-Up Studies Double-Blind Method Tenofovir Middle Aged Hepatitis B, Chronic Humans Adolescent Hepatitis B e Antigens Biomarkers Viral Load Female Antiviral Agents Aged Treatment Outcome Aged, 80 and over Young Adult Adult Male
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Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, phase 3, non-inferiority trial.

The lancet. Gastroenterology & hepatology Sep 22, 2016
BACKGROUND: Tenofovir alafenamide is a novel prodrug formulated to deliver the active metabolite to target cells more efficiently than tenofovir disoproxil fumarate at a lower dose, thereby reducing systemic exposure. In patients with HIV, tenofovir ...
Follow-Up Studies Double-Blind Method Tenofovir Hepatitis B, Chronic Hepatitis B e Antigens Middle Aged Adolescent Viral Load Antiviral Agents Treatment Outcome Adenine Alanine Humans Biomarkers Female Aged Aged, 80 and over Young Adult Adult Male
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin for chronic hepatitis C virus genotype 4 infection in Egyptian patients with or without compensated cirrhosis (AGATE-II): a multicentre, phase 3, partly randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: In Egypt, chronic hepatitis C virus (HCV) infection occurs in around 10% of the population (about 8 million individuals), and is a leading cause of liver cirrhosis, hepatocellular carcinoma, and mortality. Although HCV genotype 4 constitu...
Lactams, Macrocyclic Treatment Outcome Macrocyclic Compounds Follow-Up Studies Ribavirin Hepatitis C, Chronic Humans Cyclopropanes Sustained Virologic Response Hepacivirus Valine Female Egypt Aged Middle Aged Administration, Oral Sulfonamides Drug Administration Schedule Aged, 80 and over Proline Adolescent Anilides Young Adult Ritonavir Antiviral Agents Carbamates Adult Drug Therapy, Combination Genotype Male Liver Cirrhosis
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Ombitasvir, paritaprevir, and ritonavir plus ribavirin in adults with hepatitis C virus genotype 4 infection and cirrhosis (AGATE-I): a multicentre, phase 3, randomised open-label trial.

The lancet. Gastroenterology & hepatology Jun 16, 2016
BACKGROUND: Hepatitis C virus (HCV) genotype 4 infection is most commonly reported in sub-Saharan Africa and the Middle East; however, prevalence is increasing worldwide through immigration. HCV genotype 4 accounts for 20% of all infections, but clin...
Male Middle Aged Adolescent Antiviral Agents Genotype Treatment Outcome Follow-Up Studies Cyclopropanes Sulfonamides Hepacivirus Female Aged Aged, 80 and over Young Adult Adult Ribavirin Drug Administration Schedule Humans Sustained Virologic Response Anilides Proline Carbamates Ritonavir Lactams, Macrocyclic Drug Therapy, Combination Macrocyclic Compounds Hepatitis C, Chronic Valine
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Structure-activity relationship studies of 1-(1'-hydroxyalkyl)rupestonic acid methyl esters against influenza viruses.

Bioorganic & medicinal chemistry letters Jun 6, 2016
A series of 1-(1'-hydroxyalkyl)rupestonic acid methyl esters were synthesized via the condensation of methyl rupestonate with various aldehydes in the presence of LDA. This mixed aldol reaction was highly stereoselective and all the new compounds wer...
Esters Sesquiterpenes Crystallography, X-Ray Azulenes Orthomyxoviridae Microbial Sensitivity Tests Antiviral Agents Structure-Activity Relationship
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Using Support Vector Machine (SVM) for Classification of Selectivity of H1N1 Neuraminidase Inhibitors.

Molecular informatics Jan 15, 2016
Inhibition of the neuraminidase is one of the most promising strategies for preventing influenza virus spreading. 479 neuraminidase inhibitors are collected for dataset 1 and 208 neuraminidase inhibitors for A/P/8/34 are collected for dataset 2. Usin...
Influenza A Virus, H1N1 Subtype Quantitative Structure-Activity Relationship Computer Simulation Antiviral Agents Support Vector Machine Neuraminidase Enzyme Inhibitors
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Lopinavir Resistance Classification with Imbalanced Data Using Probabilistic Neural Networks.

Journal of medical systems Jan 6, 2016
Resistance to antiretroviral drugs has been a major obstacle for long-lasting treatment of HIV-infected patients. The development of models to predict drug resistance is recognized as useful for helping the decision of the best therapy for each HIV+ ...
HIV Infections Antiviral Agents Logistic Models Predictive Value of Tests Drug Resistance, Viral Humans Neural Networks, Computer Algorithms Software Design Lopinavir
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The antiviral activity of arctigenin in traditional Chinese medicine on porcine circovirus type 2.

Research in veterinary science Oct 26, 2015
Arctigenin (ACT) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb Arctium lappa L. (Compositae) with anti-viral and anti-inflammatory effects. Here, we investigated the antiviral activity of ACT found in tradition...
Random Allocation Lignans Arctium Mice Female Circoviridae Infections Medicine, Chinese Traditional Animals Circovirus Mice, Inbred BALB C Swine Injections, Intraperitoneal Swine Diseases Furans Antiviral Agents
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