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ATP Binding Cassette Transporter, Subfamily B, Member 1

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CONDITIONS OF PROOXIDANT ACTIVITY OF CISTUS AND POMEGRANATE POLYPHENOLS IN V79 CELL CULTURES.

Acta poloniae pharmaceutica Mar 1, 2017
Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peels (Punica granatunm L.) added at high concentrations (25-100 pg/mL) to V79 (Chinese hamster lung fibroblast) cell cultures, markedly increased intracellular le...
ATP Binding Cassette Transporter, Subfamily B, Member 1 Plant Extracts Cistus Fruit Fibroblasts Cricetinae Dose-Response Relationship, Drug Lythraceae Reactive Oxygen Species Cell Line Plants, Medicinal Polyphenols Animals Oxidative Stress Phytotherapy Hydrogen Peroxide Antioxidants
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A new model of flavonoids affinity towards P-glycoprotein: genetic algorithm-support vector machine with features selected by a modified particle swarm optimization algorithm.

Archives of pharmacal research Feb 1, 2017
Flavonoids exhibit a high affinity for the purified cytosolic NBD (C-terminal nucleotide-binding domain) of P-glycoprotein (P-gp). To explore the affinity of flavonoids for P-gp, quantitative structure-activity relationship (QSAR) models were develop...
ATP Binding Cassette Transporter, Subfamily B, Member 1 Support Vector Machine Datasets as Topic Protein Binding Flavonoids Quantitative Structure-Activity Relationship Models, Chemical Protein Domains
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Association of ATP-Binding Cassette Transporter (ABC) Gene Polymorphisms with Viral Load in Patients with Genotype 1 Hepatitis C Virus Infection.

Clinical laboratory Sep 1, 2016
BACKGROUND: ATP-binding cassette transporters (ABC) gene polymorphisms are associated with various biological functions, including hepatitis C virus (HCV) infection. This study aims to explore the impact of ABC transporters polymorphisms on HCV viral...
ATP Binding Cassette Transporter, Subfamily G, Member 5 ATP Binding Cassette Transporter, Subfamily B, Member 11 ATP Binding Cassette Transporter, Subfamily G, Member 2 Viral Load Polymorphism, Single Nucleotide Genotype ATP Binding Cassette Transporter, Subfamily B, Member 1 Hepatitis C, Chronic Humans Male Interleukins Lipoproteins Hepacivirus Gene Frequency Female Middle Aged Neoplasm Proteins ATP-Binding Cassette Transporters ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily B
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Machine learning-, rule- and pharmacophore-based classification on the inhibition of P-glycoprotein and NorA.

SAR and QSAR in environmental research Sep 1, 2016
The efflux pumps P-glycoprotein (P-gp) in humans and NorA in Staphylococcus aureus are of great interest for medicinal chemists because of their important roles in multidrug resistance (MDR). The high polyspecificity as well as the unavailability of ...
Humans Multidrug Resistance-Associated Proteins Drug Discovery Staphylococcus aureus Bacterial Proteins Databases, Chemical ATP Binding Cassette Transporter, Subfamily B, Member 1 Machine Learning Quantitative Structure-Activity Relationship Ligands Algorithms
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A method to predict different mechanisms for blood-brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine.

Journal of bioinformatics and computational biology Feb 1, 2016
The blood-brain barrier (BBB), a highly selective barrier between central nervous system (CNS) and the blood stream, restricts and regulates the penetration of compounds from the blood into the brain. Drugs that affect the CNS interact with the BBB p...
ATP Binding Cassette Transporter, Subfamily B, Member 1 Drug Evaluation, Preclinical Support Vector Machine Medicine, Chinese Traditional Plants, Medicinal Molecular Targeted Therapy Central Nervous System Agents Permeability Algorithms Reproducibility of Results Blood-Brain Barrier Models, Theoretical Humans
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