AIMC Topic: ATP Binding Cassette Transporter, Subfamily B, Member 1

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A method to predict different mechanisms for blood-brain barrier permeability of CNS activity compounds in Chinese herbs using support vector machine.

Journal of bioinformatics and computational biology Oct 27, 2015
The blood-brain barrier (BBB), a highly selective barrier between central nervous system (CNS) and the blood stream, restricts and regulates the penetration of compounds from the blood into the brain. Drugs that affect the CNS interact with the BBB p...
Algorithms Reproducibility of Results Humans Drug Evaluation, Preclinical Support Vector Machine Central Nervous System Agents Medicine, Chinese Traditional Plants, Medicinal ATP Binding Cassette Transporter, Subfamily B, Member 1 Molecular Targeted Therapy Blood-Brain Barrier Permeability Models, Theoretical
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Machine Learning Uncovers Food- and Excipient-Drug Interactions.

Cell reports Mar 17, 2020
Inactive ingredients and generally recognized as safe compounds are regarded by the US Food and Drug Administration (FDA) as benign for human consumption within specified dose ranges, but a growing body of research has revealed that many inactive ing...
Biological Assay Swine United States Food and Drug Administration United States Food Mice, Inbred BALB C ATP Binding Cassette Transporter, Subfamily B, Member 1 Pharmaceutical Preparations Drug Interactions Hep G2 Cells Abietanes Machine Learning Excipients Female Retinyl Esters Animals Diterpenes Glucuronosyltransferase Humans
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CONDITIONS OF PROOXIDANT ACTIVITY OF CISTUS AND POMEGRANATE POLYPHENOLS IN V79 CELL CULTURES.

Acta poloniae pharmaceutica Mar 1, 2017
Polyphenol rich extracts obtained from cistus herb (Cistus incanus L.) and pomegranate peels (Punica granatunm L.) added at high concentrations (25-100 pg/mL) to V79 (Chinese hamster lung fibroblast) cell cultures, markedly increased intracellular le...
Plants, Medicinal Phytotherapy Cistus Fibroblasts ATP Binding Cassette Transporter, Subfamily B, Member 1 Oxidative Stress Dose-Response Relationship, Drug Fruit Antioxidants Plant Extracts Cell Line Reactive Oxygen Species Cricetinae Animals Polyphenols Lythraceae Hydrogen Peroxide
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Association of ATP-Binding Cassette Transporter (ABC) Gene Polymorphisms with Viral Load in Patients with Genotype 1 Hepatitis C Virus Infection.

Clinical laboratory Sep 1, 2016
BACKGROUND: ATP-binding cassette transporters (ABC) gene polymorphisms are associated with various biological functions, including hepatitis C virus (HCV) infection. This study aims to explore the impact of ABC transporters polymorphisms on HCV viral...
Interleukins Neoplasm Proteins Hepacivirus Hepatitis C, Chronic ATP Binding Cassette Transporter, Subfamily B, Member 1 Polymorphism, Single Nucleotide Genotype Lipoproteins Middle Aged Viral Load ATP Binding Cassette Transporter, Subfamily G, Member 2 ATP Binding Cassette Transporter, Subfamily G, Member 5 ATP Binding Cassette Transporter 1 ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 11 Gene Frequency ATP-Binding Cassette Transporters Humans Female Male
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Machine learning-, rule- and pharmacophore-based classification on the inhibition of P-glycoprotein and NorA.

SAR and QSAR in environmental research Sep 1, 2016
The efflux pumps P-glycoprotein (P-gp) in humans and NorA in Staphylococcus aureus are of great interest for medicinal chemists because of their important roles in multidrug resistance (MDR). The high polyspecificity as well as the unavailability of ...
Multidrug Resistance-Associated Proteins Ligands Bacterial Proteins Databases, Chemical ATP Binding Cassette Transporter, Subfamily B, Member 1 Quantitative Structure-Activity Relationship Humans Machine Learning Algorithms Drug Discovery Staphylococcus aureus
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