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Artificial Intelligence, Real-World Automation and the Safety of Medicines.

Drug safety
Despite huge technological advances in the capabilities to capture, store, link and analyse data electronically, there has been some but limited impact on routine pharmacovigilance. We discuss emerging research in the use of artificial intelligence, ...

The automation of bias in medical Artificial Intelligence (AI): Decoding the past to create a better future.

Artificial intelligence in medicine
Medicine is at a disciplinary crossroads. With the rapid integration of Artificial Intelligence (AI) into the healthcare field the future care of our patients will depend on the decisions we make now. Demographic healthcare inequalities continue to p...

Embedding covariate adjustments in tree-based automated machine learning for biomedical big data analyses.

BMC bioinformatics
BACKGROUND: A typical task in bioinformatics consists of identifying which features are associated with a target outcome of interest and building a predictive model. Automated machine learning (AutoML) systems such as the Tree-based Pipeline Optimiza...

Artificial Intelligence Effecting a Paradigm Shift in Drug Development.

SLAS technology
The inverse relationship between the cost of drug development and the successful integration of drugs into the market has resulted in the need for innovative solutions to overcome this burgeoning problem. This problem could be attributed to several f...

Automatic IMRT planning via static field fluence prediction (AIP-SFFP): a deep learning algorithm for real-time prostate treatment planning.

Physics in medicine and biology
The purpose of this work was to develop a deep learning (DL) based algorithm, Automatic intensity-modulated radiotherapy (IMRT) Planning via Static Field Fluence Prediction (AIP-SFFP), for automated prostate IMRT planning with real-time planning effi...

Review on big data applications in safety research of intelligent transportation systems and connected/automated vehicles.

Accident; analysis and prevention
The era of Big Data has arrived. Recently, under the environment of intelligent transportation systems (ITS) and connected/automated vehicles (CAV), Big Data has been applied in various fields in transportation including traffic safety. In this study...

CD-NuSS: A Web Server for the Automated Secondary Structural Characterization of the Nucleic Acids from Circular Dichroism Spectra Using Extreme Gradient Boosting Decision-Tree, Neural Network and Kohonen Algorithms.

Journal of molecular biology
Nucleic acids exhibit a repertoire of conformational preference depending on the sequence and environment. Circular dichroism (CD) is an essential and valuable tool for monitoring such secondary structural conformations of nucleic acids. Nonetheless,...