AIMC Topic: Basal Ganglia
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Roles for globus pallidus externa revealed in a computational model of action selection in the basal ganglia.
Neural networks : the official journal of the International Neural Network Society
Oct 19, 2018
The basal ganglia are considered vital to action selection - a hypothesis supported by several biologically plausible computational models. Of the several subnuclei of the basal ganglia, the globus pallidus externa (GPe) has been thought of largely a...
Nonlinear predictive control for adaptive adjustments of deep brain stimulation parameters in basal ganglia-thalamic network.
Neural networks : the official journal of the International Neural Network Society
Dec 7, 2017
The efficacy of deep brain stimulation (DBS) for Parkinson's disease (PD) depends in part on the post-operative programming of stimulation parameters. Closed-loop stimulation is one method to realize the frequent adjustment of stimulation parameters....
Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance.
Clinical science (London, England : 1979)
Jun 28, 2017
In the brain, enlarged perivascular spaces (PVS) relate to cerebral small vessel disease (SVD), poor cognition, inflammation and hypertension. We propose a fully automatic scheme that uses a support vector machine (SVM) to classify the burden of PVS ...
Decision making under uncertainty in a spiking neural network model of the basal ganglia.
Journal of integrative neuroscience
Dec 21, 2016
The mechanisms of decision-making and action selection are generally thought to be under the control of parallel cortico-subcortical loops connecting back to distinct areas of cortex through the basal ganglia and processing motor, cognitive and limbi...
Uncertainty Quantification of Oscillation Suppression During DBS in a Coupled Finite Element and Network Model.
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
Sep 13, 2016
Models of the cortico-basal ganglia network and volume conductor models of the brain can provide insight into the mechanisms of action of deep brain stimulation (DBS). In this study, the coupling of a network model, under parkinsonian conditions, to ...
Functional Relevance of Different Basal Ganglia Pathways Investigated in a Spiking Model with Reward Dependent Plasticity.
Frontiers in neural circuits
Jul 21, 2016
The brain enables animals to behaviorally adapt in order to survive in a complex and dynamic environment, but how reward-oriented behaviors are achieved and computed by its underlying neural circuitry is an open question. To address this concern, we ...
Closed-Loop Modulation of the Pathological Disorders of the Basal Ganglia Network.
IEEE transactions on neural networks and learning systems
Jan 13, 2016
A generalized predictive closed-loop control strategy to improve the basal ganglia activity patterns in Parkinson's disease (PD) is explored in this paper. Based on system identification, an input-output model is established to reveal the relationshi...
Expanding the role of striatal cholinergic interneurons and the midbrain dopamine system in appetitive instrumental conditioning.
Journal of neurophysiology
Oct 14, 2015
The basal ganglia are a collection of subcortical nuclei thought to underlie a wide variety of vertebrate behavior. Although a great deal is known about the functional and physiological properties of the basal ganglia, relatively few models have been...
Cost-efficient FPGA implementation of basal ganglia and their Parkinsonian analysis.
Neural networks : the official journal of the International Neural Network Society
Aug 10, 2015
The basal ganglia (BG) comprise multiple subcortical nuclei, which are responsible for cognition and other functions. Developing a brain-machine interface (BMI) demands a suitable solution for the real-time implementation of a portable BG. In this st...
Identifying the Basal Ganglia network model markers for medication-induced impulsivity in Parkinson's disease patients.
PloS one
Jun 4, 2015
Impulsivity, i.e. irresistibility in the execution of actions, may be prominent in Parkinson's disease (PD) patients who are treated with dopamine precursors or dopamine receptor agonists. In this study, we combine clinical investigations with comput...
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