Computational models that can predict growth and remodeling of the heart could have important clinical applications. However, the time it takes to calibrate and run current models while considering data uncertainty and variability makes them impracti...
Pharmacokinetic (PK) properties of a drug are vital attributes influencing its therapeutic effectiveness, playing an important role in the drug development process. Focusing on the difficult task of predicting PK parameters, we compiled an extensive ...
INTRODUCTION: The mortality rate among older people infected with severe acute respiratory syndrome coronavirus 2 is alarmingly high. This study aimed to explore the predictive value of a novel model for assessing the risk of death in this vulnerable...
Quantifying individualized rehabilitation responses and optimizing therapy for each person is challenging. For interventions like treadmill training, there are multiple parameters, such as speed or incline, that can be adjusted throughout sessions. T...
Our brain undergoes significant micro- and macroscopic changes throughout its life cycle. It is therefore crucial to understand the effect of aging on the mechanical properties of the brain in order to develop accurate personalized simulations and di...
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
Oct 26, 2024
BACKGROUND: Bioequivalence risk assessment as an extension of quality risk management lacks examples of quantitative approaches to risk assessment at an early stage of generic drug development. The aim of our study was to develop a model-based approa...
IEEE transactions on bio-medical engineering
Oct 25, 2024
OBJECTIVE: Paraspinal muscle segmentation and reconstruction from MR images are critical to implement quantitative assessment of chronic and recurrent low back pains. Due to unclear muscle boundaries and shape variations, current segmentation methods...
The early diagnosis of diabetic retinopathy (DR) is challenging, highlighting the urgent need to identify new biomarkers. Immune responses play a crucial role in DR, yet there are currently no reports of machine learning (ML) algorithms being utilize...
Rapid and accurate identification of bacterial species is essential for the effective treatment of infectious diseases and suppression of antibiotic-resistant strains. The unique autofluorescence properties of bacterial cells are exploited for rapid ...
PURPOSE: Spontaneous bacterial peritonitis (SBP) is a bacterial infection of ascitic fluid that develops naturally, without being triggered by any surgical conditions or procedures, and is a common complication of cirrhosis. With a potential mortalit...
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