This study develops an innovative approach that integrates a colorimetric sensor array (CSA) composed of phenylalanine-modified MnO nanozymes with advanced algorithms, aiming to detect the anthrax biomarker 2,6-pyridine dicarboxylic acid (2,6-PDA) an...
The escalating global burden of Alzheimer's disease (AD), projected to reach $16.9 trillion by 2050 with disproportionate impacts on low- and middle-income countries and racial minorities, underscores an urgent need for accessible early detection too...
Progressive supranuclear palsy (PSP) is a rare and debilitating four-repeat (4R) tauopathy, characterized by motor dysfunction, cognitive decline, and oculomotor abnormalities, yet it lacks reliable biomarkers for early diagnosis, disease stratificat...
BACKGROUND: Symptomatic knee osteoarthritis (KOA) imposes a substantial global health and economic burden. Although chronological age (CA) is a key risk factor, it poorly reflects interindividual aging heterogeneity. Biological age (BA), which is qua...
Small extracellular vesicles (sEVs) play a role in the pathophysiology of viral respiratory infections and may be suitable biomarkers for COVID-19 and Influenza infections, or targets for treatment. We investigated differences in the surface proteome...
BACKGROUND: Necrotizing enterocolitis (NEC) is an inflammatory intestinal disease that primarily affects premature infants and is a major cause of death in the neonatal period. Approximately half of the affected infants require surgical intervention,...
Osteoarthritis (OA) is a chronic joint disorder characterized by cartilage degradation and accompanied by inflammatory processes. Inflammation and autophagy dysfunction have been associated with the pathogenesis of OA. However, the interplay between ...
Big biological datasets, such as gene expression profiles, often contain redundant features that degrade model performance and limit generalization across independent datasets with complexities like class imbalance and hidden sub-clusters. To overcom...
International journal of pharmaceutics
Dec 9, 2025
Exosomes are small, membrane-enclosed vesicles that can originate from a variety of sources and contain a wealth of material. They are involved in physiological processes such as cell-cell communication, cell migration, and anti-tumor immunity, and a...
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a growing global health challenge. Conventional diagnostic tools have limited sensitivity and specificity for early-stage disease. In this context, long non-coding RNAs (lncRNAs) have emerged as promisin...
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