AIMC Topic: Bipolar Disorder
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Different prefrontal cortex activity patterns in bipolar and unipolar depression during verbal fluency tasks based on functional near infrared spectroscopy study.
Scientific reports
Jul 1, 2025
This study aimed to investigate the functionality of the prefrontal cortex in patients with unipolar depression (UD) and bipolar depression (BD) using functional near-infrared spectroscopy (fNIRS) during a verbal fluency task (VFT). Additionally, it ...
Real-world effectiveness of cariprazine in major depressive disorder and bipolar I disorder in the United States.
Journal of medical economics
Jun 10, 2025
AIMS: The efficacy of cariprazine for major depressive disorder (MDD) (adjunctive therapy) and bipolar I (BP-I) depression has been demonstrated in clinical trials. This study evaluated the real-world effectiveness of cariprazine in reducing depressi...
Multivariate brain morphological patterns across mood disorders: key roles of frontotemporal and cerebellar areas.
BMJ mental health
Jun 10, 2025
BACKGROUND: Differentiating major depressive disorder (MDD) from bipolar disorder (BD) remains a significant clinical challenge, as both disorders exhibit overlapping symptoms but require distinct treatment approaches. Advances in voxel-based morphom...
Machine learning for classification of pediatric bipolar disorder with and without psychotic symptoms based on thalamic subregional structural volume.
BMC psychiatry
Jun 3, 2025
BACKGROUND: The thalamus plays a crucial role in sensory processing, emotional regulation, and cognitive functions, and its dysregulation may be implicated in psychosis. The aim of the present study was to examine the differences in thalamic subregio...
Using Digital Phenotyping to Discriminate Unipolar Depression and Bipolar Disorder: Systematic Review.
Journal of medical Internet research
May 23, 2025
BACKGROUND: Differentiating bipolar disorder (BD) from unipolar depression (UD) is essential, as these conditions differ greatly in their progression and treatment approaches. Digital phenotyping, which involves using data from smartphones or other d...
Joint resting state and structural networks characterize pediatric bipolar patients compared to healthy controls: a multimodal fusion approach.
NeuroImage
Apr 17, 2025
Pediatric bipolar disorder (PBD) is a highly debilitating condition, characterized by alternating episodes of mania and depression, with intervening periods of remission. Limited information is available about the functional and structural abnormalit...
Acoustic and Natural Language Markers for Bipolar Disorder: A Pilot, mHealth Cross-Sectional Study.
JMIR formative research
Apr 16, 2025
BACKGROUND: Monitoring symptoms of bipolar disorder (BD) is a challenge faced by mental health services. Speech patterns are crucial in assessing the current experiences, emotions, and thought patterns of people with BD. Natural language processing (...
Longitudinal brain age in first-episode mania youth treated with lithium or quetiapine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
Apr 13, 2025
It is unclear if lithium and quetiapine have neuroprotective effects, especially in early stages of bipolar and schizoaffective disorders. Here, an age-related multivariate brain structural measure (i.e., brain-PAD) at baseline and changes in respons...
Machine learning-based differentiation of schizophrenia and bipolar disorder using multiscale fuzzy entropy and relative power from resting-state EEG.
Translational psychiatry
Apr 12, 2025
Schizophrenia (SZ) and bipolar disorder (BD) pose diagnostic challenges due to overlapping clinical symptoms and genetic factors, often resulting in misdiagnosis and suboptimal treatment outcomes. This study aimed to identify EEG-based biomarkers tha...
Altered resting-state brain activity in patients with major depression disorder and bipolar disorder: A regional homogeneity analysis.
Journal of affective disorders
Mar 11, 2025
BACKGROUND: Major Depressive Disorder (MDD) and Bipolar Disorder (BD) exhibit overlapping depressive symptoms, complicating their differentiation in clinical practice. Traditional neuroimaging studies have focused on specific regions of interest, but...
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