AIMC Topic: Breast Neoplasms

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The development of predictive biomarkers and immunologic markers for breast cancer: current status and future perspectives.

Brazilian journal of biology = Revista brasleira de biologia
Breast cancer is the leading cause of cancer-related mortality among women worldwide. The development of predictive biomarkers and immunologic markers has revolutionized breast cancer diagnosis and treatment, enabling personalized medicine approaches...

MobNas ensembled model for breast cancer prediction.

Scientific reports
Breast cancer poses a real and immense threat to humankind, thus a need to develop a way of diagnosing this devastating disease early, accurately, and in a simpler manner. Thus, while substantial progress has been made in developing machine learning ...

Leveraging Digital Twins for Stratification of Patients with Breast Cancer and Treatment Optimization in Geriatric Oncology: Multivariate Clustering Analysis.

JMIR cancer
BACKGROUND: Defining optimal adjuvant therapeutic strategies for older adult patients with breast cancer remains a challenge, given that this population is often overlooked and underserved in clinical research and decision-making tools.

Interpretable prediction of drug synergy for breast cancer by random forest with features from Boolean modeling of signaling pathways.

Scientific reports
Breast cancer is a complex and challenging disease to treat, and despite progress in combating it, drug resistance remains a significant hindrance. Drug combinations have shown promising results in improving therapeutic outcomes, and many machine lea...

Imputing single-cell protein abundance in multiplex tissue imaging.

Nature communications
Multiplex tissue imaging enables single-cell spatial proteomics and transcriptomics but remains limited by incomplete molecular profiling, tissue loss, and probe failure. Here, we apply machine learning to impute single-cell protein abundance using m...

Non-invasive prediction of DCE-MRI radiomics model on CCR5 in breast cancer based on a machine learning algorithm.

Cancer biomarkers : section A of Disease markers
BackgroundNon-invasive methods with universal prognostic guidance for detecting breast cancer (BC) survival biomarkers need to be further explored.ObjectiveThis study aimed to investigate C-C motif chemokine receptor type 5 (CCR5) prognosis value in ...

Enhancing ERα-targeted compound efficacy in breast cancer threapy with ExplainableAI and GeneticAlgorithm.

PloS one
Breast cancer remains a major cause of mortality among women globally, driving the need for advanced therapeutic solutions. This study presents a novel, comprehensive methodology integrating explainable artificial intelligence (AI), machine learning ...

Preoperative DBT-based radiomics for predicting axillary lymph node metastasis in breast cancer: a multi-center study.

BMC medical imaging
BACKGROUND: In the prognosis of breast cancer, the status of axillary lymph nodes (ALN) is critically important. While traditional axillary lymph node dissection (ALND) provides comprehensive information, it is associated with high risks. Sentinel ly...

Semiautomated segmentation of breast tumor on automatic breast ultrasound image using a large-scale model with customized modules.

Scientific reports
To verify the capability of the Segment Anything Model for medical images in 3D (SAM-Med3D), tailored with low-rank adaptation (LoRA) strategies, in segmenting breast tumors in Automated Breast Ultrasound (ABUS) images. This retrospective study colle...

Gene expression and agent-based modeling improve precision prognosis in breast cancer.

Scientific reports
Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM). First, GEP will ...