BACKGROUND: Clear cell renal cell carcinoma represents the most prevalent histological subtype of renal malignancy Emerging evidence underscores the critical involvement of mitochondrial dysfunction in oncogenesis and tumor progression. In this study...
Artificial intelligence (AI) has the potential to transform nanoparticle development for drug delivery; however, existing strategies typically optimize either material selection or component ratios in isolation. To enable simultaneous optimization of...
The limited correlation between mRNA and protein levels within cells highlighted the need to study mechanisms of translational control. To decipher the factors that determine the rates of individual steps in mRNA translation, machine learning approac...
Colorectal cancer (CRC) is a major global health issue. Despite advancements in treatment, CRC patients still face challenges of metastasis and variable prognosis. Circulating tumor cells (CTCs) shed from the primary tumor into the peripheral blood c...
Endoplasmic reticulum (ER) stress and its associated unfolded protein response (UPR) have been demonstrated to play a crucial role in cancer's progression, but their prognostic significance in breast cancer (BC) remains unclear. In this study, a reli...
ACS biomaterials science & engineering
Aug 26, 2025
According to the International Agency for Research on Cancer and the World Health Organization, colorectal cancer (CRC) is the third most common cancer in the world and the main cause of gastrointestinal cancer-related deaths. Despite advances in the...
BACKGROUND: The importance of epithelial‒mesenchymal transition (EMT) in tumour invasion and metastasis in high-grade serous ovarian cancer (HGSOC) has been highlighted in numerous studies, but genetic biomarkers for predicting EMT in HGSOC are still...
Esophageal cancer (ESCA) is a significant malignancy with rising global incidence rates and considerable impacts on patient survival and quality of life. Current diagnostic and therapeutic strategies face limitations, necessitating research into its ...
International journal of pharmaceutics
Aug 24, 2025
PURPOSE: The development of a novel lipid-based formulation for apalutamide, a potent androgen receptor inhibitor for non-metastatic castration-resistant prostate cancer (nmCRPC), is explored in this study.
Target identification in natural products plays a critical role in the development of innovative drugs. Bufalin, a compound derived from traditional medicines, has shown promising anti-cancer activity; however, its precise molecular mechanism of acti...
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