AIMC Topic: Cell Line
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Deconvolution of subcellular protrusion heterogeneity and the underlying actin regulator dynamics from live cell imaging.
Nature communications
Apr 27, 2018
Cell protrusion is morphodynamically heterogeneous at the subcellular level. However, the mechanism of cell protrusion has been understood based on the ensemble average of actin regulator dynamics. Here, we establish a computational framework called ...
Cell Line, Tumor
Cell Movement
Cluster Analysis
Cell Line
Models, Biological
Humans
Machine Learning
Software
Animals
Intravital Microscopy
Actin-Related Protein 2-3 Complex
Microfilament Proteins
Potoroidae
Pseudopodia
Vasodilator-Stimulated Phosphoprotein
Phosphoproteins
Indoles
Actins
Cell Adhesion Molecules
Actin Cytoskeleton
Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity.
European journal of medicinal chemistry
Jan 31, 2018
Primaquine (PQ) is a commonly used drug that can prevent the transmission of Plasmodium falciparum malaria, however toxicity limits its use. We prepared five groups of PQ derivatives: amides 1a-k, ureas 2a-k, semicarbazides 3a,b, acylsemicarbazides 4...
A machine learning approach to integrate big data for precision medicine in acute myeloid leukemia.
Nature communications
Jan 3, 2018
Cancers that appear pathologically similar often respond differently to the same drug regimens. Methods to better match patients to drugs are in high demand. We demonstrate a promising approach to identify robust molecular markers for targeted treatm...
Essential oil of Citrus lumia Risso: Phytochemical profile, antioxidant properties and activity on the central nervous system.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 28, 2017
The use of essential oils (EOs) is known since long time in traditional medicine and aromatherapy for the management of various oxidative stress-related disorders and has been further increased recently for their neuroprotective and anti-aging potent...
Effect of bovine lactoferrin and human lactoferrin on the proliferative activity of the osteoblast cell line MC3T3-E1 in vitro.
Journal of dairy science
Dec 28, 2017
We conducted a comparative in vitro study on the proliferative effects of natural human lactoferrin (nhLF) and bovine lactoferrin (bLF) on osteoblasts. We investigated cell proliferation, cell survival, cell cycle, and mRNA and protein expression of ...
Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.
European journal of medicinal chemistry
Dec 28, 2017
Bruton's tyrosine kinase (Btk) is a Tec family kinase with a well-defined role in the B cell receptor (BCR) and Fcγ receptor (FcR) signaling pathways, which makes it a uniquely attractive target for the treatment of autoimmune diseases, such as rheum...
Structure-Activity Relationship
Models, Molecular
Molecular Structure
Dogs
Humans
Animals
Cell Proliferation
Microsomes, Liver
Protein Kinase Inhibitors
Rats, Sprague-Dawley
Drug Design
Pyrimidines
Dose-Response Relationship, Drug
Mice
Agammaglobulinaemia Tyrosine Kinase
Cell Line
Arthritis, Rheumatoid
Haplorhini
Protein-Tyrosine Kinases
Rats
Pyrroles
Chemical characterization, antioxidant, genotoxic and in vitro cytotoxic activity assessment of Juniperus communis var. saxatilis.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Dec 26, 2017
Chemical composition and antioxidative, genotoxic and cytotoxic potential of essential oil (EO) and post-distillation waste (PDW) of Serbian Juniperus communis L. var. saxatilis Pall. was studied in human lung carcinoma (A549) and normal lung fibrobl...
Humans
Female
Animals
Male
Cell Line, Tumor
Antioxidants
Plant Extracts
Cell Division
Drug Screening Assays, Antitumor
Rats
G2 Phase
Tandem Mass Spectrometry
Apoptosis
Juniperus
Gas Chromatography-Mass Spectrometry
Cell Line
Doxorubicin
Antineoplastic Agents, Phytogenic
Mutagens
Chromatography, Liquid
Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans.
Endocrine
Dec 22, 2017
PURPOSE: Growth hormone (GH) therapy in adults alters thyroid function, and acromegaly often involves thyroid disease. The present study aimed to elucidate roles and mechanisms of GH in regulating thyroid function.
Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates.
Phytomedicine : international journal of phytotherapy and phytopharmacology
Dec 21, 2017
BACKGROUND: Clinical methicillin-resistant Staphylococcus aureus (MRSA) is a thorny problem in current anti-infective therapeutics and a challenge of new drug development. Plant prenylflavonoids possess anti-MRSA activity, but few of the prenylflavon...
Comparison, alignment, and synchronization of cell line information between CLO and EFO.
BMC bioinformatics
Dec 21, 2017
BACKGROUND: The Experimental Factor Ontology (EFO) is an application ontology driven by experimental variables including cell lines to organize and describe the diverse experimental variables and data resided in the EMBL-EBI resources. The Cell Line ...
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