AIMC Topic: Child
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Applying exposure-response analysis to enhance Mycophenolate Mofetil dosing precision in pediatric patients with immune-mediated renal diseases by machine learning models.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
May 28, 2025
BACKGROUND: Mycophenolate mofetil (MMF), a cornerstone immunosuppressant for lupus nephritis, is increasingly used off-label in pediatric immune-mediated renal diseases. The aims of this study were to develop and validate pharmacokinetic models for m...
Leveraging pre-vaccination antibody titres across multiple influenza H3N2 variants to forecast the post-vaccination response.
EBioMedicine
May 26, 2025
BACKGROUND: Despite decades of research on the influenza virus, we still lack a predictive understanding of how vaccination reshapes each person's antibody response, which impedes efforts to design better vaccines. Models using pre-vaccination antibo...
Study protocol for the Rainbow Austrian Longitudinal Family (RALF) study: a longitudinal, multi-method, multi-rater investigation of risk and resilience factors in Austrian LGBTQ+ parent families.
BMC psychology
May 26, 2025
BACKGROUND: Research on LGBTQ+ parent families is evolving to include a growing range of family systems, identities, methodologies, and topics. However, studies that examine minority-specific risk and resilience factors and their associations with wi...
A pediatric ECG database with disease diagnosis covering 11643 children.
Scientific data
May 26, 2025
Electrocardiogram (ECG) is a common non-invasive diagnostic tool for cardiovascular diseases. Adequate data is crucial in utilizing deep learning to achieve intelligent diagnosis of ECG. The existing ECG datasets almost only focus on adults and most ...
Transcriptome combined with Mendelian randomization to identify key genes related to polyamine metabolism in childhood obesity and elucidate their molecular regulatory mechanisms.
Scientific reports
May 22, 2025
Currently, research has found a close correlation between childhood obesity (CO) and elevated levels of polyamines in the bloodstream. Thus, the identification of key genes associated with polyamines metabolism in CO could offer fresh insights for cl...
Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.
Gut microbes
May 21, 2025
Alterations in the gut microbiome affect the development and severity of metabolic dysfunction-associated steatotic liver disease (MASLD) or metabolic dysfunction-associated steatohepatitis (MASH). We analyzed microbiomes of obese children with and w...
Harnessing Fast Fourier Transform for Rapid Community Travel Distance and Step Estimation in Children with Duchenne Muscular Dystrophy.
Sensors (Basel, Switzerland)
May 21, 2025
Accurate estimation of gait characteristics, including step length, step velocity, and travel distance, is critical for assessing mobility in toddlers, children, and teens with Duchenne muscular dystrophy (DMD) and typically developing (TD) peers. Th...
Co-designing an online educational resource to help adolescents improve their digital health literacy.
BMC public health
May 21, 2025
BACKGROUND: Digital media is ubiquitous in adolescents' lives and provides many opportunities to engage with health information. However, there is an increased risk of engaging with inaccurate or biased health information on the internet, resulting i...
Morphometric and radiomics analysis toward the prediction of epilepsy associated with supratentorial low-grade glioma in children.
Cancer imaging : the official publication of the International Cancer Imaging Society
May 19, 2025
OBJECTIVES: Understanding the impact of epilepsy on pediatric brain tumors is crucial to diagnostic precision and optimal treatment selection. This study investigated MRI radiomics features, tumor location, voxel-based morphometry (VBM) for gray matt...
Efficacy of using a digital health intervention model using community health workers for primary health services in Bangladesh: a repeated cross-sectional observational study.
BMC public health
May 19, 2025
OBJECTIVE: This study aims to evaluate the effectiveness of a digital health intervention model by observing people's health conditions in a rural area of Bangladesh. Through a repeated cross-sectional design, health outcomes were assessed at six-mon...
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