AIMC Topic: Chitosan

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Nanocomplexes composed of chitosan derivatives and β-Lactoglobulin as a carrier for anthocyanins: Preparation, stability and bioavailability in vitro.

Food research international (Ottawa, Ont.) Aug 22, 2018
To improve sustained-release property, stability and bioavailability of anthocyanins (ACNs) in vitro, we fabricated the nanocomplexes with chitosan hydrochloride (CHC), carboxymethyl chitosan (CMC) and β-Lactoglobulin (β-Lg). Response surface methodo...
Drug Stability Gastrointestinal Tract Lactoglobulins In Vitro Techniques Particle Size Nanoparticles Drug Carriers Chitosan Anthocyanins Biological Availability
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Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.

Journal of materials science. Materials in medicine Dec 30, 2017
In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell-cell and cell-matrix interactions that are essential for β-cell retention, viability and functional...
Scattering, Radiation Spheroids, Cellular Trans-Activators Microscopy, Fluorescence Cadherins Animals Molecular Dynamics Simulation Insulin Insulin Secretion Mice Insulin-Secreting Cells Carbon Spectroscopy, Fourier Transform Infrared Cell Culture Techniques Lasers Cell Survival Betaine Microscopy, Electron, Scanning Chitosan Homeodomain Proteins Surface Properties
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Carbon dots-modified chitosan based electrochemical biosensing platform for detection of vitamin D.

International journal of biological macromolecules Dec 21, 2017
Here in, a carbon dots (CDs)-modified chitosan (CH) based biosensing platform was fabricated for vitamin D detection. Carbon dots were synthesized through microwave pyrolysis method, and characterized with transmission electron microscopy, Raman spec...
Chitosan Quantum Dots Electrochemical Techniques Nanocomposites Citric Acid Microscopy, Atomic Force Dielectric Spectroscopy Reproducibility of Results Biosensing Techniques Vitamin D Carbon
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Chitosan/nanohydroxyapatite composite based scallop shells as an efficient adsorbent for mercuric ions: Static and dynamic adsorption studies.

International journal of biological macromolecules Dec 19, 2017
Chitosan/nanohydroxyapatite composites based on scallop shells (CP12, CP14 and CP21) were prepared with different chitosan: nanohydroxyapatite ratios (1:2, 1:4 and 2:1, respectively). Nanohydroxyapatite (P), chitosan(C) and their composites were char...
Hydrogen-Ion Concentration Nanocomposites Mercury Durapatite Water Pollutants, Chemical Adsorption Chitosan
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Novel cationic chitosan derivative bearing 1,2,3-triazolium and pyridinium: Synthesis, characterization, and antifungal property.

Carbohydrate polymers Nov 7, 2017
In this paper, novel cationic chitosan derivative possessing 1,2,3-triazolium and pyridinium groups was synthesized conveniently via cuprous-catalyzed azide-alkyne cycloaddition (CuAAC) and methylation. FTIR, H NMR, and elemental analysis examined th...
Triazoles Pyridinium Compounds Cations Microbial Sensitivity Tests Dose-Response Relationship, Drug Chitosan Structure-Activity Relationship Antifungal Agents Molecular Structure Fusarium
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Synthesis, characterization and antifungal efficacy of C-coordinated O-carboxymethyl chitosan Cu(II) complexes.

Carbohydrate polymers Dec 21, 2016
A novel type of O-carboxymethyl chitosan Schiff bases (O-CSPX) was synthesized via a condensation reaction. After the coordination reaction of cupric ions, Cu(II) complexes (O-CSPX-Cu) were achieved. The theoretical structure of O-CSPX-Cu calculated ...
Schiff Bases Gibberella Phyllachorales Phytophthora Spectroscopy, Fourier Transform Infrared Chitosan Copper Fungicides, Industrial
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Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks.

International journal of biological macromolecules Jan 16, 2016
At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium tripolyphosphate (TPP) concentrations and mass ratios were optimized to improve the process yield without undesirable particle flocculation. Prepared formulations ...
Hydrogen-Ion Concentration Nanotechnology Drug Compounding Polyphosphates Neural Networks, Computer Nanoparticles Chitosan Drug Carriers
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Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.

Journal of pharmaceutical sciences Dec 23, 2015
Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology requires the development of formulations with higher concentrations to reach therapeutic dosages. Polyplexe...
Luciferases HEK293 Cells Plasmids Surface Properties Humans Nanoparticles Cell Survival Gene Transfer Techniques Polyethyleneimine Green Fluorescent Proteins Freeze Drying Chitosan Drug Carriers DNA
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Preparation, characterization and toxicological investigation of copper loaded chitosan nanoparticles in human embryonic kidney HEK-293 cells.

Materials science & engineering. C, Materials for biological applications Dec 18, 2015
Metallic nanoparticles often attribute severe adverse effects to the various organs or tissues at the molecular level despite of their applications in medical, laboratory and industrial sectors. The present study highlights the preparation of copper ...
Humans Nanoparticles Reactive Oxygen Species Cytotoxins HEK293 Cells Copper Sulfate Chitosan Copper Cell Death
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Cytotoxicity of chitosan/streptokinase nanoparticles as a function of size: An artificial neural networks study.

Nanomedicine : nanotechnology, biology, and medicine Sep 25, 2015
Predicting the size and toxicity of chitosan/streptokinase nanoparticles at various values of processing parameters was the aim of this study. For the first time, a comprehensive model could be developed to determine the cytotoxicity of the nanoparti...
Nanocomposites Pattern Recognition, Automated Algorithms Toxicity Tests Reproducibility of Results Streptokinase Sensitivity and Specificity Dose-Response Relationship, Drug Cell Survival Chitosan Structure-Activity Relationship Particle Size Hydrogen-Ion Concentration Drug Evaluation, Preclinical Neural Networks, Computer
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