AIMC Topic: Insulin Secretion

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Acute hyperglycaemia in cystic fibrosis pulmonary exacerbations.

Endocrinology, diabetes & metabolism Nov 30, 2020
BACKGROUND: Hyperglycaemia may contribute to failure to recover from pulmonary exacerbations in cystic fibrosis (CF). We aimed to evaluate the prevalence and mechanism of hyperglycaemia during and post-exacerbations.
Glucose Tolerance Test Adolescent Child Insulin Secretion Hyperglycemia Monitoring, Physiologic Male Humans Acute Disease Female Disease Progression Cystic Fibrosis Young Adult Prevalence
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Simultaneous spatiotemporal tracking and oxygen sensing of transient implants in vivo using hot-spot MRI and machine learning.

Proceedings of the National Academy of Sciences of the United States of America Feb 26, 2019
A varying oxygen environment is known to affect cellular function in disease as well as activity of various therapeutics. For transient structures, whether they are unconstrained therapeutic transplants, migrating cells during tumor metastasis, or ce...
Oxygen Animals Islets of Langerhans Transplantation Prostheses and Implants Imaging, Three-Dimensional Biocompatible Materials Fluorine Immunity Magnetic Resonance Imaging Machine Learning Insulin Secretion Alginates Halogenation Cluster Analysis Mice, Inbred C57BL Partial Pressure
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Carboxybetaine-modified succinylated chitosan-based beads encourage pancreatic β-cells (Min-6) to form islet-like spheroids under in vitro conditions.

Journal of materials science. Materials in medicine Dec 30, 2017
In vitro, pancreatic β-cells tend to reduce their ability to aggregate into islets and lose insulin-producing ability, likely due to insufficient cell-cell and cell-matrix interactions that are essential for β-cell retention, viability and functional...
Trans-Activators Mice Spectroscopy, Fourier Transform Infrared Animals Homeodomain Proteins Insulin Scattering, Radiation Spheroids, Cellular Insulin Secretion Lasers Microscopy, Electron, Scanning Microscopy, Fluorescence Carbon Surface Properties Cell Culture Techniques Cadherins Cell Survival Betaine Insulin-Secreting Cells Molecular Dynamics Simulation Chitosan
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Circulating triacylglycerols but not pancreatic fat associate with insulin secretion in healthy humans.

Metabolism: clinical and experimental Dec 19, 2017
BACKGROUND: Loss of adequate insulin secretion for the prevailing insulin resistance is critical for the development of type 2 diabetes and has been suggested to result from circulating lipids (triacylglycerols [TG] or free fatty acids) and/or adipoc...
Fatty Acids, Nonesterified Triglycerides Insulin Secretion Adiponectin Insulin-Secreting Cells Aged Male Middle Aged Insulin Insulin Resistance Humans Lipids Female
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Resolution of type 2 diabetes after sleeve gastrectomy: a 2-step hypothesis.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Dec 14, 2017
BACKGROUND: Weight loss (WL) and altered gut hormonal levels are involved in glucose homeostasis after laparoscopic sleeve gastrectomy (LSG).
Prospective Studies Insulin Secretion Female Ghrelin Young Adult Gastrectomy Glucagon-Like Peptide 1 Bariatric Surgery Humans Obesity, Morbid Weight Loss Adult Insulin Resistance Blood Glucose Male Insulin Laparoscopy Middle Aged Diabetes Mellitus, Type 2 Glycated Hemoglobin
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Long-term clinical and functional impact of biliopancreatic diversion on type 2 diabetes in morbidly and non-morbidly obese patients.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery Dec 10, 2015
SETTING: Obesity surgery has been proposed as a treatment option for diabetic patients with body mass index (BMI)<35 kg/m(2), but the efficacy of metabolic surgery has not been conclusively determined.
Humans Adult Male Middle Aged Weight Loss Prospective Studies Female Aged Glycated Hemoglobin Body Mass Index Insulin Secretion Obesity Insulin-Secreting Cells Postoperative Care Biliopancreatic Diversion Blood Glucose Insulin Diabetes Mellitus, Type 2
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