AIMC Topic: Computer Simulation

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Recent progresses in the exploration of machine learning methods as in-silico ADME prediction tools.

Advanced drug delivery reviews May 30, 2015
In-silico methods have been explored as potential tools for assessing ADME and ADME regulatory properties particularly in early drug discovery stages. Machine learning methods, with their ability in classifying diverse structures and complex mechanis...
Models, Biological Pharmacokinetics Machine Learning Computer Simulation Pharmaceutical Preparations Humans
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[Medicine and robotics].

Medicina clinica May 23, 2015
Robotics Equipment Design Telemedicine Surgical Procedures, Operative Forecasting Man-Machine Systems Computer Simulation Humans Cybernetics User-Computer Interface
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Non-parametric temporal modeling of the hemodynamic response function via a liquid state machine.

Neural networks : the official journal of the International Neural Network Society May 21, 2015
Standard methods for the analysis of functional MRI data strongly rely on prior implicit and explicit hypotheses made to simplify the analysis. In this work the attention is focused on two such commonly accepted hypotheses: (i) the hemodynamic respon...
Models, Statistical Data Interpretation, Statistical Oxygen Hemodynamics Image Processing, Computer-Assisted Magnetic Resonance Imaging Markov Chains Datasets as Topic Humans Algorithms Neural Networks, Computer Computer Simulation Machine Learning Reproducibility of Results
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Surface modeling of workpiece and tool trajectory planning for spray painting robot.

PloS one May 18, 2015
Automated tool trajectory planning for spray-painting robots is still a challenging problem, especially for a large free-form surface. A grid approximation of a free-form surface is adopted in CAD modeling in this paper. A free-form surface model is ...
Robotics Algorithms Surface Properties Computer Simulation Paintings Models, Theoretical
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Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Delayed-Action Preparations Poloxamer Polysorbates Solubility Nanomedicine Technology, Pharmaceutical Surface Properties Calcium Channel Blockers Chemistry, Pharmaceutical Polymers Kinetics Lipids Verapamil Drug Carriers Models, Chemical Neural Networks, Computer Nanoparticles Particle Size Algorithms Computer Simulation
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Undamped Oscillations Generated by Hopf Bifurcations in Fractional-Order Recurrent Neural Networks With Caputo Derivative.

IEEE transactions on neural networks and learning systems May 14, 2015
In this paper, a fractional-order recurrent neural network is proposed and several topics related to the dynamics of such a network are investigated, such as the stability, Hopf bifurcations, and undamped oscillations. The stability domain of the tri...
Nonlinear Dynamics Biological Clocks Computer Simulation Humans Neural Networks, Computer Feedback Algorithms Time Factors
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Experimental design strategy: weak reinforcement leads to increased hit rates and enhanced chemical diversity.

Journal of chemical information and modeling May 14, 2015
High Throughput Screening (HTS) is a common approach in life sciences to discover chemical matter that modulates a biological target or phenotype. However, low assay throughput, reagents cost, or a flowchart that can deal with only a limited number o...
Algorithms Computer Simulation Bayes Theorem Drug Evaluation, Preclinical Machine Learning
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An Asynchronous Recurrent Network of Cellular Automaton-Based Neurons and Its Reproduction of Spiking Neural Network Activities.

IEEE transactions on neural networks and learning systems May 13, 2015
Modeling and implementation approaches for the reproduction of input-output relationships in biological nervous tissues contribute to the development of engineering and clinical applications. However, because of high nonlinearity, the traditional mod...
Humans Neural Networks, Computer Computer Simulation Neurons Synapses Hippocampus Nerve Net Animals Models, Neurological Action Potentials
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Measuring information transfer in a soft robotic arm.

Bioinspiration & biomimetics May 13, 2015
Soft robots can exhibit diverse behaviors with simple types of actuation by partially outsourcing control to the morphological and material properties of their soft bodies, which is made possible by the tight coupling between control, body, and envir...
Extremities Models, Biological Biomimetics Computer Simulation Elastic Modulus Information Storage and Retrieval Animals Octopodiformes Robotics
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Bioinspired locomotion and grasping in water: the soft eight-arm OCTOPUS robot.

Bioinspiration & biomimetics May 13, 2015
The octopus is an interesting model for the development of soft robotics, due to its high deformability, dexterity and rich behavioural repertoire. To investigate the principles of octopus dexterity, we designed an eight-arm soft robot and evaluated ...
Computer Simulation Ships Animals Swimming Hand Strength Extremities Equipment Failure Analysis Robotics Octopodiformes Equipment Design Models, Biological
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