BACKGROUND: Vaccine hesitancy, the delay in acceptance or reluctance to vaccinate, ranks among the top threats to global health. Identifying modifiable factors contributing to vaccine hesitancy is crucial for developing targeted interventions to incr...
The rapid deployment of COVID-19 vaccines has necessitated the ongoing surveillance of adverse events, with abnormal uterine bleeding (AUB) emerging as a reported concern in vaccinated females. We aimed to develop a machine learning (ML) model to pre...
OBJECTIVE: Adverse event (AE) extraction following COVID-19 vaccines from text data is crucial for monitoring and analyzing the safety profiles of immunizations, identifying potential risks and ensuring the safe use of these products. Traditional dee...
PURPOSE: Many individuals with inborn errors of immunity (IEIs) have poor humoral immune (HI) vaccine responses. Only a few studies have examined specific cell-mediated immune (CMI) responses to coronavirus disease 2019 (COVID-19) vaccines in this po...
Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening. This study leverages artificial i...
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Dec 4, 2024
The coronavirus disease 2019 pandemic has underscored the importance of vaccines, especially for immunocompromised populations like solid organ transplant recipients, who often have weaker immune responses. The purpose of this study was to compare de...
OBJECTIVE: This study aimed to outline a machine learning model to assess the effectiveness of vaccination in COVID-19 confirmed cases and fatalities. The proposed model was evaluated using external validation to ensure optimal protection of vaccinat...
Pandemics like COVID-19 have a huge impact on human society and the global economy. Vaccines are effective in the fight against these pandemics but often in limited supplies, particularly in the early stages. Thus, it is imperative to distribute such...
In this study, we introduce a novel approach that integrates interpretability techniques from both traditional machine learning (ML) and deep neural networks (DNN) to quantify feature importance using global and local interpretation methods. Our meth...
Next-generation T-cell-directed vaccines for COVID-19 focus on establishing lasting T-cell immunity against current and emerging SARS-CoV-2 variants. Precise identification of conserved T-cell epitopes is critical for designing effective vaccines. He...
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