Messenger RNA (mRNA) vaccines face core challenges including low-delivery efficiency and immunogenicity, limiting their wide-ranging applications in infectious disease prevention and cancer therapy. Lipid nanoparticles (LNPs), the most clinically val...
Due to the widespread COVID-19 vaccinations, we are focusing more on side effects to immunizations that might affect people's perceptions, and ultimately vaccine hesitancy. Machine learning (ML)-based predictive models using individual-level data ser...
Biochemical and biophysical research communications
Nov 7, 2025
Vaccination stands as one of the most significant achievements in public health, dramatically reducing the incidence of infectious diseases worldwide. The COVID-19 pandemic has catalyzed revolutionary advancements in vaccinology, particularly through...
Despite the success of messenger RNA (mRNA) COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that uses transformer architectures tailored for mRNA coding seq...
Vaccine hesitancy threatens to erode one of medicine's greatest achievements. Recent measles outbreaks in Europe and the United States illustrate the consequences of declining confidence. At the centre lies misinformation, amplified through digital n...
Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have demonstrated strong efficacy in preventing symptomatic disease, but adverse cardiovascular side effects have been reported. This study investigated whether noninvasive...
Understanding vaccine hesitancy is a critical public health challenge, yet traditional statistical methods often fail to capture the complex drivers behind it. This study uses COVID-19 vaccine hesitancy in a rural population as a case study to demons...
ConspectusThe clinical use of mRNA COVID-19 vaccines developed by Moderna and Pfizer-BioNTech has highlighted the critical role of ionizable lipid nanoparticles (LNPs) in the efficient loading, intracellular delivery, and cytoplasmic release of mRNAs...
Using social media recruitment for public health research presents both opportunities and challenges. Despite its increased use, few studies have detailed the practical issues, challenges encountered, and alternative strategies available for social m...
A key issue in the post-COVID-19 pandemic era is the ongoing administration of COVID-19 vaccines. Repeated vaccination is essential for preparing against currently circulating and newly emerging severe acute respiratory syndrome coronavirus 2 (SARS-C...
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