AIMC Topic: Crohn Disease

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Developing a Neural Network Model for a Non-invasive Prediction of Histologic Activity in Inflammatory Bowel Diseases.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology Mar 1, 2021
BACKGROUND: Colonoscopy with biopsy is the "gold" standard for evaluating disease activity in inflammatory bowel diseases (IBD). Current research is geared toward finding non-invasive, cost-efficient methods that estimate disease activity. We aimed t...
Humans Neural Networks, Computer Artificial Intelligence Feces Colitis, Ulcerative Crohn Disease Leukocyte L1 Antigen Complex Biomarkers Inflammatory Bowel Diseases Reproducibility of Results
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Brief Survey on Machine Learning in Epistasis.

Methods in molecular biology (Clifton, N.J.) Jan 1, 2021
In biology, the term "epistasis" indicates the effect of the interaction of a gene with another gene. A gene can interact with an independently sorted gene, located far away on the chromosome or on an entirely different chromosome, and this interacti...
Epistasis, Genetic Quantitative Trait, Heritable Inheritance Patterns Computational Biology Crohn Disease Plants Alzheimer Disease Genome, Human Macular Degeneration Data Mining Neoplasms Genome-Wide Association Study Polymorphism, Single Nucleotide Humans Machine Learning Phenotype
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Predicting Corticosteroid-Free Biologic Remission with Vedolizumab in Crohn's Disease.

Inflammatory bowel diseases May 18, 2018
BACKGROUND AND AIMS: Vedolizumab (VDZ) is effective for Crohn's disease (CD) but costly and is slow to produce remission. Early knowledge of whether vedolizumab is likely to succeed is valuable for physicians, patients, and insurers.
ROC Curve Treatment Outcome Antibodies, Monoclonal, Humanized Male Middle Aged Cohort Studies Crohn Disease Gastrointestinal Agents Remission Induction Adrenal Cortex Hormones Biological Products C-Reactive Protein Area Under Curve Humans Young Adult Adult Machine Learning Female
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A probabilistic pathway score (PROPS) for classification with applications to inflammatory bowel disease.

Bioinformatics (Oxford, England) Mar 15, 2018
SUMMARY: Gene-based supervised machine learning classification models have been widely used to differentiate disease states, predict disease progression and determine effective treatment options. However, many of these classifiers are sensitive to no...
Models, Biological Supervised Machine Learning Diagnosis, Differential Metabolic Networks and Pathways Crohn Disease Gene Regulatory Networks Computational Biology Colitis, Ulcerative Humans Adult Child Disease Progression Protein Interaction Maps
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Dosing interval and diagnosis predict infliximab levels in patients with inflammatory bowel disease on maintenance treatment.

Acta gastro-enterologica Belgica Jan 1, 2018
OBJECTIVE: The aim of the study was to identify factors influencing infliximab (IFX) trough levels (TL) in patients with inflammatory bowel disease (IBD).
Infliximab Crohn Disease Gastrointestinal Agents Treatment Outcome Remission Induction Colitis, Ulcerative Humans Antibodies, Monoclonal Inflammatory Bowel Diseases Cross-Sectional Studies
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Validation of Neutrophil CD64 Blood Biomarkers to Detect Mucosal Inflammation in Pediatric Crohn's Disease.

Inflammatory bowel diseases Dec 19, 2017
BACKGROUND: In a pilot study, neutrophil CD64 surface expression was significantly elevated in newly diagnosed, pediatric-onset Crohn's disease. We aimed to test the CD64 biomarkers (neutrophil CD64 surface expression and soluble CD64) as determinate...
Intestinal Mucosa Crohn Disease Receptors, IgG Male Severity of Illness Index Female Case-Control Studies Humans Inflammation Young Adult Child, Preschool Pilot Projects Biomarkers Neutrophils Adult Adolescent Child Cohort Studies
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LOWER LEVELS OF VITAMIN D CORRELATE WITH CLINICAL DISEASE ACTIVITY AND QUALITY OF LIFE IN INFLAMMATORY BOWEL DISEASE.

Arquivos de gastroenterologia Dec 1, 2015
BACKGROUND: Inflammatory bowel disease, comprising Crohn's disease and ulcerative colitis, is a group of debilitating conditions associated with deregulated mucosal immune response. Vitamin D has been implicated in immune response and gastrointestina...
Cross-Sectional Studies Male Quality of Life Vitamin D Deficiency Colitis, Ulcerative Severity of Illness Index Vitamin D Humans Female Adult Crohn Disease
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Robotic right colectomy with intracorporeal anastomosis--a video vignette.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland Nov 1, 2015
Colectomy Ileum Crohn Disease Colon, Transverse Humans Anastomosis, Surgical Robotics
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