AIMC Topic: Depressive Disorder, Major
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Machine learning based differential diagnosis of schizophrenia, major depression disorder and bipolar disorder using structural magnetic resonance imaging.
Journal of affective disorders
Apr 24, 2025
BACKGROUND: Cortical morphological abnormalities in schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BD) have been identified in past research. However, their potential as objective biomarkers to differentiate these disorde...
Specific expression and common potential therapeutic drugs in different brain regions of major depressive disorder patients: bioinformatics analysis.
Journal of affective disorders
Apr 24, 2025
Major depressive disorder (MDD) is a prevalent and debilitating mental health condition characterized by persistent feelings of sadness and loss of interest. Despite its high prevalence, the underlying molecular mechanisms remain poorly understood. T...
Integrative analysis of signaling and metabolic pathways, immune infiltration patterns, and machine learning-based diagnostic model construction in major depressive disorder.
Scientific reports
Apr 19, 2025
Major depressive disorder (MDD) is a multifactorial disorder involving genetic and environmental factors, with unclear pathogenesis. This study aims to explore the pathogenic pathway of MDD and its relationship with immune responses and to discover i...
Semantic signals in self-reference: The detection and prediction of depressive symptoms from the daily diary entries of a sample with major depressive disorder.
Journal of psychopathology and clinical science
Apr 10, 2025
Individuals with major depressive disorder (MDD) experience fewer positive and more negative emotions and use fewer positive words to describe themselves. Natural language processing techniques have been used to predict depression, with pronoun and e...
Gene age gap estimate (GAGE) for major depressive disorder: A penalized biological age model using gene expression.
Neurobiology of aging
Apr 1, 2025
Recent associations between Major Depressive Disorder (MDD) and measures of premature aging suggest accelerated biological aging as a potential biomarker for MDD susceptibility or MDD as a risk factor for age-related diseases. Residuals or "gaps" bet...
Multivariate Classification of Adolescent Major Depressive Disorder Using Whole-brain Functional Connectivity.
Academic radiology
Mar 29, 2025
RATIONALE AND OBJECTIVES: Adolescent major depressive disorder (MDD) is a serious mental health condition that has been linked to abnormal functional connectivity (FC) patterns within the brain. However, whether FC could be used as a potential biomar...
Altered resting-state brain activity in patients with major depression disorder and bipolar disorder: A regional homogeneity analysis.
Journal of affective disorders
Mar 11, 2025
BACKGROUND: Major Depressive Disorder (MDD) and Bipolar Disorder (BD) exhibit overlapping depressive symptoms, complicating their differentiation in clinical practice. Traditional neuroimaging studies have focused on specific regions of interest, but...
A machine learning approach to predict treatment efficacy and adverse effects in major depression using CYP2C19 and clinical-environmental predictors.
Psychiatric genetics
Mar 5, 2025
BACKGROUND: Major depressive disorder (MDD) is among the leading causes of disability worldwide and treatment efficacy is variable across patients. Polymorphisms in cytochrome P450 2C19 (CYP2C19) play a role in response and side effects to medication...
Circadian rhythm modulation in heart rate variability as potential biomarkers for major depressive disorder: A machine learning approach.
Journal of psychiatric research
Mar 4, 2025
Major depressive disorder (MDD) is associated with reduced heart rate variability (HRV), but its link to circadian rhythm modulation (CRM) of HRV is unclear. Given that depression disrupts circadian rhythms, assessing HRV fluctuations may better capt...
Bootstrap inference and machine learning reveal core differential plasma metabolic connectome signatures in major depressive disorder.
Journal of affective disorders
Mar 3, 2025
BACKGROUND: Major depressive disorder (MDD) involves molecular alterations and pathway dysregulation. Metabolic interconnections are crucial for normal functioning, yet current analysis focuses on individual pathways or biomarkers, overlooking intric...
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