AIMC Topic: Disease Progression

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Using Relevance Feedback to Distinguish the Changes in EEG During Different Absence Seizure Phases.

Clinical EEG and neuroscience
We carried out a series of statistical experiments to explore the utility of using relevance feedback on electroencephalogram (EEG) data to distinguish between different activity states in human absence epilepsy. EEG recordings from 10 patients with ...

Artificial neural networks in neurosurgery.

Journal of neurology, neurosurgery, and psychiatry
Artificial neural networks (ANNs) effectively analyze non-linear data sets. The aimed was A review of the relevant published articles that focused on the application of ANNs as a tool for assisting clinical decision-making in neurosurgery. A literatu...

Bridging scales in cancer progression: mapping genotype to phenotype using neural networks.

Seminars in cancer biology
In this review we summarise our recent efforts in trying to understand the role of heterogeneity in cancer progression by using neural networks to characterise different aspects of the mapping from a cancer cells genotype and environment to its pheno...

Unraveling risk factors and transcriptomic signatures in liver cancer progression and mortality through machine learning and bioinformatics.

Briefings in functional genomics
Liver cancer (LC) is the second leading cause of cancer-related deaths globally, yet the molecular mechanisms linking its progression with associated risk factors (RFs) remain poorly understood. To address this, we developed an integrative multi-stag...

Combined magnetic resonance imaging and serum analysis reveals distinct multiple sclerosis types.

Brain : a journal of neurology
Multiple sclerosis (MS) is a highly heterogeneous disease in its clinical manifestation and progression. Predicting individual disease courses is key for aligning treatments with underlying pathobiology. We developed an unsupervised machine learning ...

Development and validation of multi-center serum creatinine-based models for noninvasive prediction of kidney fibrosis in chronic kidney disease.

Renal failure
OBJECTIVE: Kidney fibrosis is a key pathological feature in the progression of chronic kidney disease (CKD), traditionally diagnosed through invasive kidney biopsy. This study aimed to develop and validate a noninvasive, multi-center predictive model...

Identification of early prognostic biomarkers in Severe Fever with Thrombocytopenia Syndrome using machine learning algorithms.

Annals of medicine
OBJECTIVE: We aimed at identifying acute phase biomarkers in Severe Fever with Thrombocytopenia Syndrome (SFTS), and to establish a model to predict mortality outcomes.

Identifying azithromycin responders with an individual treatment effect model in COPD.

Thorax
OBJECTIVE: Long-term azithromycin treatment effectively prevents acute exacerbations of chronic obstructive pulmonary disease (COPD). However, patients would benefit from better identification of responders and non-responders to minimise unnecessary ...

In Silico Digital Twins of Bone Metastasis Enable Investigation of Tumor Progression and Therapy Response.

Cancer research
UNLABELLED: Bone metastasis (BM) is a leading cause of morbidity and mortality in patients with prostate and renal cancer. The complex and dynamic biological processes driving its progression present significant challenges for both understanding and ...