AIMC Topic: DNA

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Automated Classification and Cluster Visualization of Genotypes Derived from High Resolution Melt Curves.

PloS one Nov 25, 2015
INTRODUCTION: High Resolution Melting (HRM) following PCR has been used to identify DNA genotypes. Fluorescent dyes bounded to double strand DNA lose their fluorescence with increasing temperature, yielding different signatures for different genotype...
DNA Algorithms Transition Temperature Polymerase Chain Reaction Automation, Laboratory Genotyping Techniques Genotype Humans Machine Learning Software
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CompGO: an R package for comparing and visualizing Gene Ontology enrichment differences between DNA binding experiments.

BMC bioinformatics Sep 2, 2015
BACKGROUND: Gene ontology (GO) enrichment is commonly used for inferring biological meaning from systems biology experiments. However, determining differential GO and pathway enrichment between DNA-binding experiments or using the GO structure to cla...
Computational Biology DNA Gene Ontology Genes, Homeobox Humans Genomics
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Nanorobots: Changing Trends in Cancer Therapy.

The journal of contemporary dental practice Sep 1, 2015
Nanostructures Nanomedicine Molecular Targeted Therapy Neoplasms Robotics DNA Biotechnology Humans
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Machine learning approach for pooled DNA sample calibration.

BMC bioinformatics Jul 9, 2015
BACKGROUND: Despite ongoing reduction in genotyping costs, genomic studies involving large numbers of species with low economic value (such as Black Tiger prawns) remain cost prohibitive. In this scenario DNA pooling is an attractive option to reduce...
Genotype Cluster Analysis DNA Calibration Gene Frequency Machine Learning Humans Genomics Polymorphism, Single Nucleotide
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A k-mer-based barcode DNA classification methodology based on spectral representation and a neural gas network.

Artificial intelligence in medicine Jul 4, 2015
OBJECTIVES: In this paper, an alignment-free method for DNA barcode classification that is based on both a spectral representation and a neural gas network for unsupervised clustering is proposed.
Reproducibility of Results Animals Computational Biology Neural Networks, Computer Algorithms Decision Trees DNA Supervised Machine Learning DNA Barcoding, Taxonomic Support Vector Machine Databases, Genetic Cluster Analysis Base Sequence Species Specificity
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Construction of a fuzzy and Boolean logic gates based on DNA.

Small (Weinheim an der Bergstrasse, Germany) Jan 7, 2015
Logic gates are devices that can perform logical operations by transforming a set of inputs into a predictable single detectable output. The hybridization properties, structure, and function of nucleic acids can be used to make DNA-based logic gates....
Computers, Molecular Fuzzy Logic DNA Equipment Design Signal Processing, Computer-Assisted Equipment Failure Analysis
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RNA splicing. The human splicing code reveals new insights into the genetic determinants of disease.

Science (New York, N.Y.) Dec 18, 2014
To facilitate precision medicine and whole-genome annotation, we developed a machine-learning technique that scores how strongly genetic variants affect RNA splicing, whose alteration contributes to many diseases. Analysis of more than 650,000 intron...
Mutation, Missense Quantitative Trait Loci RNA Splicing Child Development Disorders, Pervasive Humans Colorectal Neoplasms, Hereditary Nonpolyposis Artificial Intelligence Muscular Atrophy, Spinal Genetic Variation RNA-Binding Proteins Molecular Sequence Annotation Models, Genetic Introns Nuclear Proteins Adaptor Proteins, Signal Transducing Computer Simulation DNA Genome-Wide Association Study Genetic Markers Polymorphism, Single Nucleotide Exons Genetic Code MutL Protein Homolog 1 RNA Splice Sites
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repDNA: a Python package to generate various modes of feature vectors for DNA sequences by incorporating user-defined physicochemical properties and sequence-order effects.

Bioinformatics (Oxford, England) Dec 10, 2014
UNLABELLED: In order to develop powerful computational predictors for identifying the biological features or attributes of DNAs, one of the most challenging problems is to find a suitable approach to effectively represent the DNA sequences. To facili...
Oligonucleotides Humans Software Computational Biology Support Vector Machine Sequence Analysis, DNA DNA
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Internal validation of the QIAamp DNA Investigator Kit, QIAamp 96 DNA Swab BioRobot Kit and the BioRobot Universal System for DNA extraction from reference and crime scene samples.

Forensic science international. Genetics Nov 1, 2014
DNA Specimen Handling Forensic Genetics Humans Robotics
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Estimation of teaching-learning-based optimization primer design using regression analysis for different melting temperature calculations.

IEEE transactions on nanobioscience Sep 12, 2014
Primers plays important role in polymerase chain reaction (PCR) experiments, thus it is necessary to select characteristic primers. Unfortunately, manual primer design manners are time-consuming and easy to get human negligence because many PCR const...
Polymerase Chain Reaction Analysis of Variance Transition Temperature Regression Analysis Algorithms DNA DNA Primers Base Sequence Humans Artificial Intelligence
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