AIMC Topic: Dopamine Plasma Membrane Transport Proteins

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Decoding the dopamine transporter imaging for the differential diagnosis of parkinsonism using deep learning.

European journal of nuclear medicine and molecular imaging May 19, 2022
PURPOSE: This work attempts to decode the discriminative information in dopamine transporter (DAT) imaging using deep learning for the differential diagnosis of parkinsonism.
Deep Learning Parkinson Disease Diagnosis, Differential Positron-Emission Tomography Parkinsonian Disorders Multiple System Atrophy Dopamine Plasma Membrane Transport Proteins Humans Brain
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Data-driven identification of diagnostically useful extrastriatal signal in dopamine transporter SPECT using explainable AI.

Scientific reports Nov 25, 2021
This study used explainable artificial intelligence for data-driven identification of extrastriatal brain regions that can contribute to the interpretation of dopamine transporter SPECT with I-FP-CIT in parkinsonian syndromes. A total of 1306 I-FP-CI...
Humans Parkinson Disease Diagnosis, Differential Predictive Value of Tests Radiopharmaceuticals Neural Networks, Computer Brain Retrospective Studies Reproducibility of Results Dopamine Plasma Membrane Transport Proteins Image Interpretation, Computer-Assisted Nerve Degeneration Tomography, Emission-Computed, Single-Photon Tropanes
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Automated assessment of the substantia nigra on susceptibility map-weighted imaging using deep convolutional neural networks for diagnosis of Idiopathic Parkinson's disease.

Parkinsonism & related disorders Mar 17, 2021
OBJECTIVES: Despite its use in determining nigrostriatal degeneration, the lack of a consistent interpretation of nigrosome 1 susceptibility map-weighted imaging (SMwI) limits its generalized applicability. To implement and evaluate a diagnostic algo...
Tropanes Parkinson Disease, Secondary Dopamine Plasma Membrane Transport Proteins Parkinson Disease Positron-Emission Tomography Image Interpretation, Computer-Assisted Substantia Nigra Retrospective Studies Female Reproducibility of Results Aged Male Middle Aged Deep Learning Magnetic Resonance Imaging Humans
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Machine learning methods for optimal prediction of motor outcome in Parkinson's disease.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) Jan 7, 2020
PURPOSE: It is vital to appropriately power clinical trials towards discovery of novel disease-modifying therapies for Parkinson's disease (PD). Thus, it is critical to improve prediction of outcome in PD patients.
Pattern Recognition, Automated Tomography, Emission-Computed, Single-Photon Dopamine Plasma Membrane Transport Proteins Middle Aged Treatment Outcome Parkinson Disease Algorithms Computer Simulation Female Reproducibility of Results Aged Aged, 80 and over Adult Humans Male Machine Learning
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Automatic classification of dopamine transporter SPECT: deep convolutional neural networks can be trained to be robust with respect to variable image characteristics.

European journal of nuclear medicine and molecular imaging Aug 31, 2019
PURPOSE: This study investigated the potential of deep convolutional neural networks (CNN) for automatic classification of FP-CIT SPECT in multi-site or multi-camera settings with variable image characteristics.
Parkinson Disease Automation Tomography, Emission-Computed, Single-Photon Dopamine Plasma Membrane Transport Proteins Aged Male Deep Learning Image Processing, Computer-Assisted Humans Female
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Feasible Classified Models for Parkinson Disease from Tc-TRODAT-1 SPECT Imaging.

Sensors (Basel, Switzerland) Apr 11, 2019
The neuroimaging techniques such as dopaminergic imaging using Single Photon Emission Computed Tomography (SPECT) with Tc-TRODAT-1 have been employed to detect the stages of Parkinson's disease (PD). In this retrospective study, a total of 202 Tc-TRO...
Organotechnetium Compounds Aged, 80 and over Adult Humans Retrospective Studies Support Vector Machine Male Tomography, Emission-Computed, Single-Photon Female Middle Aged Parkinson Disease Tropanes Aged Dopamine Dopaminergic Neurons Corpus Striatum Dopamine Plasma Membrane Transport Proteins
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Refining diagnosis of Parkinson's disease with deep learning-based interpretation of dopamine transporter imaging.

NeuroImage. Clinical Sep 10, 2017
Dopaminergic degeneration is a pathologic hallmark of Parkinson's disease (PD), which can be assessed by dopamine transporter imaging such as FP-CIT SPECT. Until now, imaging has been routinely interpreted by human though it can show interobserver va...
Middle Aged Algorithms Humans Parkinson Disease Tomography, Emission-Computed, Single-Photon Female Neuroimaging Neural Networks, Computer Tropanes Aged Radionuclide Imaging Machine Learning Dopamine Plasma Membrane Transport Proteins Male
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Differentiating Treatment-Resistant Depression With and Without Parkinsonism in the Elderly From a Psychiatric Perspective by Tc-TRODAT-1 SPECT Imaging.

International journal of geriatric psychiatry Jun 1, 2025
OBJECTIVES: Late-life depression often overlaps with neurodegenerative diseases leading to diagnostic and treatment challenges for neuropsychiatrists. This study aimed to differentiate elderly treatment-resistant depression (TRD) comorbid with parkin...
Male Middle Aged Case-Control Studies Diagnosis, Differential Machine Learning Female Aged Aged, 80 and over Tropanes Dopamine Plasma Membrane Transport Proteins Depressive Disorder, Treatment-Resistant Organotechnetium Compounds Humans Radiopharmaceuticals Parkinsonian Disorders Corpus Striatum Tomography, Emission-Computed, Single-Photon
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High-accuracy Automated Diagnosis of Parkinson's Disease.

Current medical imaging Jan 1, 2020
PURPOSE: Parkinson's disease (PD), which is the second most common neurodegenerative disease following Alzheimer's disease, can be diagnosed clinically when about 70% of the dopaminergic neurons are lost and symptoms are noticed. Neuroimaging methods...
Humans Neural Networks, Computer Middle Aged Image Processing, Computer-Assisted Tomography, Emission-Computed, Single-Photon Parkinson Disease Predictive Value of Tests Dopamine Plasma Membrane Transport Proteins Neuroimaging Corpus Striatum
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