AIMC Topic: Drosophila Proteins
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Artificial Fish Swarm Optimization Based Method to Identify Essential Proteins.
IEEE/ACM transactions on computational biology and bioinformatics
Aug 15, 2018
It is well known that essential proteins play an extremely important role in controlling cellular activities in living organisms. Identifying essential proteins from protein protein interaction (PPI) networks is conducive to the understanding of cell...
A machine learning based framework to identify and classify long terminal repeat retrotransposons.
PLoS computational biology
Apr 23, 2018
Transposable elements (TEs) are repetitive nucleotide sequences that make up a large portion of eukaryotic genomes. They can move and duplicate within a genome, increasing genome size and contributing to genetic diversity within and across species. A...
Multitask Protein Function Prediction through Task Dissimilarity.
IEEE/ACM transactions on computational biology and bioinformatics
Mar 17, 2017
Automated protein function prediction is a challenging problem with distinctive features, such as the hierarchical organization of protein functions and the scarcity of annotated proteins for most biological functions. We propose a multitask learning...
A New Feature Vector Based on Gene Ontology Terms for Protein-Protein Interaction Prediction.
IEEE/ACM transactions on computational biology and bioinformatics
Apr 20, 2016
Protein-protein interaction (PPI) plays a key role in understanding cellular mechanisms in different organisms. Many supervised classifiers like Random Forest (RF) and Support Vector Machine (SVM) have been used for intra or inter-species interaction...
Transcriptomes of lineage-specific Drosophila neuroblasts profiled by genetic targeting and robotic sorting.
Development (Cambridge, England)
Dec 23, 2015
A brain consists of numerous distinct neurons arising from a limited number of progenitors, called neuroblasts in Drosophila. Each neuroblast produces a specific neuronal lineage. To unravel the transcriptional networks that underlie the development ...
Genome-Wide Detection and Analysis of Multifunctional Genes.
PLoS computational biology
Oct 5, 2015
Many genes can play a role in multiple biological processes or molecular functions. Identifying multifunctional genes at the genome-wide level and studying their properties can shed light upon the complexity of molecular events that underpin cellular...
An integrated CAD/CAM/robotic milling method for custom cementless femoral prostheses.
Medical engineering & physics
Jul 22, 2015
Aseptic loosening is the primary cause of cementless femoral prosthesis failure and is related to the primary stability of the cementless femoral prosthesis in the femoral cavity. The primary stability affects both the osseointegration and the long-t...
Computational algorithms to predict Gene Ontology annotations.
BMC bioinformatics
Apr 17, 2015
BACKGROUND: Gene function annotations, which are associations between a gene and a term of a controlled vocabulary describing gene functional features, are of paramount importance in modern biology. Datasets of these annotations, such as the ones pro...
The interaction of UBR4, LRP1, and OPHN1 in refractory epilepsy: Drosophila model to investigate the oligogenic effect on epilepsy.
Neurobiology of disease
Aug 1, 2025
Refractory epilepsy is an intractable neurological disorder that can be associated with oligogenic/polygenic etiologies. Through trio-based whole-exome sequencing analysis, we identified a clinical case of refractory epilepsy with three candidate gen...
D-Aspartate amends reproductive performance of aged roosters by changing gene expression and testicular histology.
Reproduction, fertility, and development
Jun 1, 2018
Male broiler breeders (n=32) of 55 weeks of age were administered four different doses of capsulated d-aspartate (DA; 0, 100, 200 or 300mgkg-1day-1, p.o. (DA0, DA100, DA200 and DA300 respectively)) for 12 successive weeks to assess reproductive perfo...
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