AIMC Topic: Drug Carriers
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Salinomycin-loaded lipid-polymer nanoparticles with anti-CD20 aptamers selectively suppress human CD20+ melanoma stem cells.
Acta pharmacologica Sinica
Dec 14, 2017
Melanoma is the deadliest type of skin cancer. CD20+ melanoma stem cells (CSCs) are pivotal for metastasis and initiation of melanoma. Therefore, selective elimination of CD20+ melanoma CSCs represents an effective treatment to eradicate melanoma. Sa...
Design, preparation and characterization of pH-responsive prodrug micelles with hydrolyzable anhydride linkages for controlled drug delivery.
Journal of colloid and interface science
Dec 31, 2016
We report a new prodrug micelle-based approach in which a model hydrophobic non-steroidal anti-inflammatory drug (NSAID), ibuprofen (Ibu), is tethered to amphiphilic methoxy polyethylene glycol-polypropylene fumarate (mPEG-PPF) diblock copolymer via ...
Drug Carriers
Surface Properties
Anti-Inflammatory Agents, Non-Steroidal
Ibuprofen
Humans
Rabbits
Micelles
Anhydrides
Animals
Prodrugs
Fumarates
Hydrogen-Ion Concentration
Nanoparticles
HeLa Cells
Cell Line
Hydrophobic and Hydrophilic Interactions
Cell Survival
Polypropylenes
Polyethylene Glycols
Hydrolysis
Solubility
Drug Liberation
Concurrent study of stability and cytotoxicity of a novel nanoemulsion system - an artificial neural networks approach.
Pharmaceutical development and technology
Oct 25, 2016
Problems commonly associated with using nanoemulsions are their cytotoxic effects and low stability profiles. Here, for the first time, concentrations of ingredients of a nanoemulsion system were investigated to obtain the most stable nanoemulsion sy...
Chitosan-tripolyphosphate nanoparticles: Optimization of formulation parameters for improving process yield at a novel pH using artificial neural networks.
International journal of biological macromolecules
Jan 16, 2016
At a novel pH value of the polymeric solution (6.2), variable chitosan (Cs) and sodium tripolyphosphate (TPP) concentrations and mass ratios were optimized to improve the process yield without undesirable particle flocculation. Prepared formulations ...
Preparation of Concentrated Chitosan/DNA Nanoparticle Formulations by Lyophilization for Gene Delivery at Clinically Relevant Dosages.
Journal of pharmaceutical sciences
Dec 23, 2015
Chitosan/DNA polyplexes have been optimized for efficient and safe in vitro and in vivo gene delivery. Clinical application of this technology requires the development of formulations with higher concentrations to reach therapeutic dosages. Polyplexe...
Preparation, characterization and biocompatibility studies of thermoresponsive eyedrops based on the combination of nanostructured lipid carriers (NLC) and the polymer Pluronic F-127 for controlled delivery of ibuprofen.
Pharmaceutical development and technology
Dec 20, 2015
CONTEXT: Nanostructured lipid carrier (NLC) dispersions present low viscosity and poor mucoadhesive properties, which reduce the pre-corneal residence time and consequently, the bioavailability of ocular drugs.
Degradable Magnetic Composites for Minimally Invasive Interventions: Device Fabrication, Targeted Drug Delivery, and Cytotoxicity Tests.
Advanced materials (Deerfield Beach, Fla.)
Nov 25, 2015
Superparamagnetic nanoparticles and a functional, degradable polymer matrix based on poly(ethylene glycol) are combined to enable fully degradable magnetic microdevices for minimally invasive biomedical applications. A bioinspired helical microrobot ...
Towards soft robotic devices for site-specific drug delivery.
Expert review of medical devices
Sep 28, 2015
Considerable research efforts have recently been dedicated to the establishment of various drug delivery systems (DDS) that are mechanical/physical, chemical and biological/molecular DDS. In this paper, we report on the recent advances in site-specif...
Optimization of controlled release nanoparticle formulation of verapamil hydrochloride using artificial neural networks with genetic algorithm and response surface methodology.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
May 16, 2015
This study was performed to optimize the formulation of polymer-lipid hybrid nanoparticles (PLN) for the delivery of an ionic water-soluble drug, verapamil hydrochloride (VRP) and to investigate the roles of formulation factors. Modeling and optimiza...
Nanoparticles
Particle Size
Lipids
Drug Carriers
Neural Networks, Computer
Algorithms
Computer Simulation
Solubility
Nanomedicine
Technology, Pharmaceutical
Surface Properties
Calcium Channel Blockers
Models, Chemical
Polymers
Kinetics
Verapamil
Chemistry, Pharmaceutical
Delayed-Action Preparations
Poloxamer
Polysorbates
Extracellular vesicles as nature's nano carriers in cancer therapy: Insights toward preclinical studies and clinical applications.
Pharmacological research
Jul 1, 2025
Extracellular vesicles (EVs), which are secreted by various cell types, hold significant potential for cancer therapy. However, there are several challenges and difficulties that limit their application in clinical settings. This review, which integr...
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