AIMC Topic: Drug Delivery Systems
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Preliminary study on alginate/NIPAM hydrogel-based soft microrobot for controlled drug delivery using electromagnetic actuation and near-infrared stimulus.
Biomedical microdevices
Nov 16, 2018
Currently, microrobots are receiving attention because of their small size and motility, which can be applied to minimal invasive therapy. Additionally, various microrobots using hydrogel with the characteristics of biocompatibility and biodegradabil...
Comparative Study for Optimization of Pharmaceutical Self-Emulsifying Pre-concentrate by Design of Experiment and Artificial Neural Network.
AAPS PharmSciTech
Sep 14, 2018
The present investigation aimed to optimize the critical parameters affecting the globule size of self-emulsifying drug delivery system. Based on preliminary screening, three critical parameters, viz., amount of oil, surfactant, and co-surfactant wer...
Machine Learning for Drug-Target Interaction Prediction.
Molecules (Basel, Switzerland)
Aug 31, 2018
Identifying drug-target interactions will greatly narrow down the scope of search of candidate medications, and thus can serve as the vital first step in drug discovery. Considering that in vitro experiments are extremely costly and time-consuming, h...
Identification of novel immune-relevant drug target genes for Alzheimer's Disease by combining ontology inference with network analysis.
CNS neuroscience & therapeutics
Aug 14, 2018
AIMS: Alzheimer's disease (AD) is one of the leading causes of death in elderly people. Its pathogenesis is greatly associated with the abnormality of immune system. However, only a few immune-relevant AD drug target genes have been discovered up to ...
Cell-Like Micromotors.
Accounts of chemical research
Aug 3, 2018
In the past decade, versatile micro- and nanosized machines have emerged as active agents for large-scale detoxification, sensing, microfabrication, and many other promising applications. Micromachines have also been envisioned as the next advancemen...
A Capsule-Type Microrobot with Pick-and-Drop Motion for Targeted Drug and Cell Delivery.
Advanced healthcare materials
Feb 20, 2018
A capsule-type microrobot exhibits "pick-and-drop" (P&D) motion to hold a particle within a confined volume and transports it via a corkscrewing motion. The P&D motion is possible because the capsule-type microrobot has two parts: a plunger and a cap...
Aerosol delivery during spontaneous breathing with different types of nebulizers- in vitro/ex vivo models evaluation.
Pulmonary pharmacology & therapeutics
Dec 19, 2017
BACKGROUND: Nebulizers for spontaneous breathing have been evaluated through different study designs. There are limitations in simulated bench models related to patient and nebulizer factors. The aim of this study was to determine the correlation of ...
Enhanced antitumor efficacy of doxorubicin-encapsulated halloysite nanotubes.
International journal of nanomedicine
Dec 19, 2017
To improve the antitumor efficacy of doxorubicin (DOX) and provide novel clinical treatment of gastric cancer, halloysite nanotubes (HNTs) loaded with DOX were encapsulated by soybean phospholipid (LIP) and the formed HNTs/DOX/LIP was systematically ...
Toltrazuril mixed nanomicelle delivery system based on sodium deoxycholate-Brij C20 polyethylene ether-triton x100: Characterization, solubility, and bioavailability study.
Colloids and surfaces. B, Biointerfaces
Dec 16, 2017
Toltrazuril (Tol) is a broad-spectrum anticoccidiosis drug that is widely used in the prevention and treatment of coccidiosis infection in poultry and mammals. However, the drug has poor aqueous solubility (25 °C, 0.41 μg/mL), and its dose escalation...
Drug target ontology to classify and integrate drug discovery data.
Journal of biomedical semantics
Nov 9, 2017
BACKGROUND: One of the most successful approaches to develop new small molecule therapeutics has been to start from a validated druggable protein target. However, only a small subset of potentially druggable targets has attracted significant research...
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