AIMC Topic: Drug Delivery Systems
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Smart MXene-based microrobots for targeted drug delivery and synergistic therapies.
Nanoscale
Apr 10, 2025
MXenes and their composites exhibit remarkable electrical conductivity, mechanical flexibility, and biocompatibility, making them ideal candidates for microrobot fabrication. Their tunable surface chemistry allows for easy functionalization, which en...
An oral robotic pill reliably and safely delivers teriparatide with high bioavailability in healthy volunteers: A phase 1 study.
British journal of clinical pharmacology
Apr 7, 2025
AIMS: The incidence of osteoporosis is projected to exceed 70 million people over the age of 65 years by 2030. Osteoanabolic agents, such as teriparatide and abaloparatide, are not only effective in reducing fracture incidence but also improve skelet...
Smart nanomedicines powered by artificial intelligence: a breakthrough in lung cancer diagnosis and treatment.
Medical oncology (Northwood, London, England)
Mar 25, 2025
Lung cancer remains one of the leading causes of cancer-related mortality worldwide, primarily due to challenges in early detection, suboptimal therapeutic efficacy, and severe adverse effects associated with conventional treatments. The convergence ...
Multiple Instance Learning-Based Prediction of Blood-Brain Barrier Opening Outcomes Induced by Focused Ultrasound.
IEEE transactions on bio-medical engineering
Mar 21, 2025
OBJECTIVE: Targeted blood-brain barrier (BBB) opening using focused ultrasound (FUS) and micro/nanobubbles is a promising method for brain drug delivery. This study aims to explore the feasibility of multiple instance learning (MIL) in accurate and f...
Utilization of machine learning approach for production of optimized PLGA nanoparticles for drug delivery applications.
Scientific reports
Mar 14, 2025
This study investigates utilization of machine learning for the regression task of predicting the size of PLGA (Poly lactic-co-glycolic acid) nanoparticles. Various inputs including category and numeric were considered for building the model to predi...
AI-driven innovations in smart multifunctional nanocarriers for drug and gene delivery: A mini-review.
Critical reviews in oncology/hematology
Mar 13, 2025
The convergence of artificial intelligence (AI) and nanomedicine has revolutionized the design of smart multifunctional nanocarriers (SMNs) for drug and gene delivery, offering unprecedented precision, efficiency, and personalization in therapeutic a...
Living material-derived intelligent micro/nanorobots.
Biomaterials science
Mar 11, 2025
Living materials, which include various types of cells, organelles, and biological components from animals, plants, and microorganisms, have become central to recent investigations in micro and nanorobotics. Living material-derived intelligent micro/...
Machine learning-assisted design of immunomodulatory lipid nanoparticles for delivery of mRNA to repolarize hyperactivated microglia.
Drug delivery
Mar 3, 2025
Regulating inflammatory microglia presents a promising strategy for treating neurodegenerative and autoimmune disorders, yet effective therapeutic agents delivery to these cells remains a challenge. This study investigates modified lipid nanoparticle...
A new era of psoriasis treatment: Drug repurposing through the lens of nanotechnology and machine learning.
International journal of pharmaceutics
Feb 23, 2025
Psoriasis is a persistent inflammatory skin disorder characterized by hyper-proliferation and abnormal epidermal differentiation. Conventional treatments such as; topical therapies, phototherapy, systemic immune modulators, and biologics aim to relie...
Using mathematical modelling and AI to improve delivery and efficacy of therapies in cancer.
Nature reviews. Cancer
Feb 19, 2025
Mathematical modelling has proven to be a valuable tool in predicting the delivery and efficacy of molecular, antibody-based, nano and cellular therapy in solid tumours. Mathematical models based on our understanding of the biological processes at su...
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