International journal of pharmaceutics
Nov 4, 2025
Liposomes have transformed drug delivery by enhancing the solubility, stability, and bioavailability of therapeutic agents, driving widespread clinical adoption and contributing to a rapidly expanding multi-billion-dollar market. However, despite the...
Existing oral drug delivery modalities often fall short in medical emergencies due to the absence of readily deployable, internalized drug storage and delivery mechanisms that combine long-term standby with rapid activation. To address this challenge...
The liquid and solid formulations of self-nano-emulsifying drug delivery systems (SNEDDS) have garnered significant attention in the pharmaceutical field for their ability to enhance the solubility and absorption of hydrophobic drugs. While both liqu...
Integrating machine learning (ML) into nanotechnology represents a promising strategy for rational design and accelerated development of drug delivery systems. However, studies in this field are scarce and face methodological and interpretative probl...
Oral administration is an ideal method for drug delivery, but achieving targeted drug delivery to the colon remains a challenge. In this study, a magnetic microrobot incorporating a colon-specific method was developed, featuring both time-dependent a...
Developing poly(lactic-co-glycolic) acid (PLGA) nanoparticles with optimized drug encapsulation and loading is crucial for effective drug delivery. However, controlling the physicochemical properties of these nanoparticles remains challenging. In thi...
Journal of controlled release : official journal of the Controlled Release Society
Oct 25, 2025
Ionic liquids (ILs) have emerged as a transformative platform in drug delivery, overcoming key limitations of conventional systems such as poor drug solubility, low bioavailability, and inadequate targeting. Through rational cation-anion engineering,...
Nanoparticle-based therapies have gained attention in recent years as promising treatments for rheumatoid arthritis (RA), due to the potential offered for targeted delivery, controlled drug release, and improved biocompatibility. A deep understanding...
Microfluidic technologies have revolutionized the synthesis of nanocarriers for drug and gene delivery, providing unparalleled precision and efficiency in the production of therapeutic nanoparticles. This review highlights recent advancements in micr...
Journal of controlled release : official journal of the Controlled Release Society
Oct 22, 2025
The design of ultrasound (US)-responsive nanocarriers (URNs) guided by their physicochemical characteristics represents a pivotal strategy for advancing cancer therapy. By exploiting the intrinsic physicochemical properties of diverse nanocarriers, i...
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