AIMC Topic: Drug Delivery Systems
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Development of fucoidan/polyethyleneimine based sorafenib-loaded self-assembled nanoparticles with machine learning and DoE-ANN implementation: Optimization, characterization, and in-vitro assessment for the anticancer drug delivery.
International journal of biological macromolecules
Aug 27, 2024
This study aims to develop sorafenib-loaded self-assembled nanoparticles (SFB-SANPs) using the combined approach of artificial neural network and design of experiments (ANN-DoE) and to compare it with other machine learning (ML) models. The central c...
Leveraging artificial intelligence for better translation of fibre-based pharmaceutical systems into real-world benefits.
Pharmaceutical development and technology
Aug 24, 2024
The increasing prominence of biologics in the pharmaceutical market requires more advanced delivery systems to deliver these delicate and complex drug molecules for better therapeutic outcomes. Fibre technology has emerged as a promising approach for...
3D-printed microrobots for biomedical applications.
Biomaterials science
Aug 20, 2024
Microrobots, which can perform tasks in difficult-to-reach parts of the human body under their own or external power supply, are potential tools for biomedical applications, such as drug delivery, microsurgery, imaging and monitoring, tissue engineer...
Predicting tissue distribution and tumor delivery of nanoparticles in mice using machine learning models.
Journal of controlled release : official journal of the Controlled Release Society
Aug 16, 2024
Nanoparticles (NPs) can be designed for targeted delivery in cancer nanomedicine, but the challenge is a low delivery efficiency (DE) to the tumor site. Understanding the impact of NPs' physicochemical properties on target tissue distribution and tum...
Light-Driven Microrobots for Targeted Drug Delivery.
ACS biomaterials science & engineering
Aug 15, 2024
As a new micromanipulation tool with the advantages of small size, flexible movement and easy manipulation, light-driven microrobots have a wide range of prospects in biomedical fields such as drug targeting and cell manipulation. Recently, microrobo...
Enhancing targeted tumor treatment: A novel fuzzy logic framework for precision drug delivery strategy selection.
Computers in biology and medicine
Aug 14, 2024
OBJECTIVE: This study aims to address the challenge of selecting optimal drug delivery strategies for tumor patients by introducing a novel theoretical framework.
Machine learning of Raman spectra predicts drug release from polysaccharide coatings for targeted colonic delivery.
Journal of controlled release : official journal of the Controlled Release Society
Aug 12, 2024
Colonic drug delivery offers numerous pharmaceutical opportunities, including direct access to local therapeutic targets and drug bioavailability benefits arising from the colonic epithelium's reduced abundance of cytochrome P450 enzymes and particul...
DeepBP: A transformer-based model for identifying blood-brain barrier penetrating peptides with data augmentation using feedback GAN.
Journal of advanced research
Aug 5, 2024
INTRODUCTION: The blood-brain barrier (BBB) serves as a critical structural barrier and impedes the entry of most neurotherapeutic drugs into the brain. This poses substantial challenges for central nervous system (CNS) drug development, as there is ...
Biorobotic Drug Delivery for Biomedical Applications.
Molecules (Basel, Switzerland)
Aug 2, 2024
Despite extensive efforts, current drug-delivery systems face biological barriers and difficulties in bench-to-clinical use. Biomedical robotic systems have emerged as a new strategy for drug delivery because of their innovative diminutive engines. T...
3D printed dosage forms, where are we headed?
Expert opinion on drug delivery
Jul 24, 2024
INTRODUCTION: 3D Printing (3DP) is an innovative fabrication technology that has gained enormous popularity through its paradigm shifts in manufacturing in several disciplines, including healthcare. In this past decade, we have witnessed the impact o...
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