AIMC Topic: Drug Delivery Systems

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Self-assembling peptide hydrogels: design, mechanisms, characterization, and biomedical applications.

Soft matter
Self-assembled peptide hydrogels have emerged as a research frontier in biomedical engineering due to their exceptional water-retention capacity and spatiotemporal drug release kinetics. Researchers can fabricate biomaterials with customizable struct...

Self-Driving and Detachable Lab-Microrobots Tailor Drug Delivery for Closed-Loop Stimulation of the Antitumor Immune Cycle.

ACS nano
Hypoxia arises in most solid tumors with insufficient blood flow, which hinders the delivery and efficacy of therapeutic agents to tumors. In this work, utilizing anaerobic bacteria capable of seeking out hypoxic areas for flourishing, we constructed...

Magnetic-Driven Hydrogel Robots Loaded with Mitomycin for Active Therapy of Bladder Cancer.

ACS applied materials & interfaces
Intravesical drug instillation is a common treatment for bladder cancer, but it suffers from poor targeting and suboptimal patient experience due to the influence of gravity. Here, we innovatively designed a bladder cancer treatment method using sodi...

Engineered multi-domain lipid nanoparticles for targeted delivery.

Chemical Society reviews
Engineered lipid nanoparticles (LNPs) represent a breakthrough in targeted drug delivery, enabling precise spatiotemporal control essential to treat complex diseases such as cancer and genetic disorders. However, the complexity of the delivery proces...

Exploring the role of density functional theory in the design of gold nanoparticles for targeted drug delivery: a systematic review.

Journal of molecular modeling
CONTEXT: Targeted drug delivery systems leveraging gold nanoparticles (AuNPs) demand precise atomic-level design to overcome current limitations in drug-loading efficiency and controlled release. Unlike previous focused reviews, this systematic analy...

Tracheal Targeted Nanogrid Delivery Systems of Dexamethasone Visualized by Single-Particle Tracing and Multiscale Pathological Mapping.

ACS nano
Current clinical treatment of pulmonary diseases requires an advanced three-dimensional (3D) pathological atlas of the microenvironment, particularly the trachea, which is predominantly affected by lung disorders. In this study, the gridded cyclodext...

Recent Advances in Microalgae Robots for Biomedical Applications.

ACS biomaterials science & engineering
Microalgae robots are an emerging biohybrid microrobot that combines the biological properties of microalgae with microrobot technology and shows a wide range of applications in the medical field. In recent years, it has been found that microalgae ar...

Advances in brain-targeted delivery strategies and natural product-mediated enhancement of blood-brain barrier permeability.

Journal of nanobiotechnology
The blood-brain barrier (BBB) represents a formidable challenge in the treatment of neurological disorders, as it restricts the passage of most therapeutic agents into the central nervous system (CNS). Research in brain-targeted delivery strategies a...

Debugging the dynamics of protein corona: Formation, composition, challenges, and applications at the nano-bio interface.

Advances in colloid and interface science
The intricate interplay between nanomaterials and the biological molecules has garnered considerable interest in understanding the dynamics of protein corona formation at the nano-bio interface. This review provides an in-depth exploration of protein...

Comparative examination of the chemistry and biology of AI-driven gold NPs in Theranostics: New insights into biosensing, bioimaging, genomics, diagnostics, and therapy.

Nanomedicine : nanotechnology, biology, and medicine
Integrating artificial intelligence (AI) with nanomedicine is transforming Theranostics, driving advances in biosensing, bioimaging, genomics, diagnostics, and treatment. This review highlights the latest advancements in AI-driven nanomedicine, focus...