AIMC Topic: Drug Resistance

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Predictive modeling of treatment resistant depression using data from STAR*D and an independent clinical study.

PloS one Jun 7, 2018
Identification of risk factors of treatment resistance may be useful to guide treatment selection, avoid inefficient trial-and-error, and improve major depressive disorder (MDD) care. We extended the work in predictive modeling of treatment resistant...
Predictive Value of Tests Models, Biological Antidepressive Agents Drug Resistance Risk Factors Adult Male Depressive Disorder, Major Humans Machine Learning Databases, Factual Female
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Effect of Pulsed Radiofrequency Treatment on the Thoracic Medial Branch for Managing Chronic Thoracic Facet Joint Pain Refractory to Medial Branch Block with Local Anesthetics.

World neurosurgery Dec 30, 2017
OBJECTIVE: To evaluate the effect of pulsed radiofrequency (PRF) stimulation of the thoracic medial branch of the dorsal ramus in patients with chronic thoracic facet joint (TFJ) pain who were refractory to medial branch block (MBB).
Nerve Block Back Pain Adult Humans Treatment Outcome Drug Resistance Male Prospective Studies Anesthetics, Local Pulsed Radiofrequency Treatment Middle Aged Female Pain Measurement Zygapophyseal Joint Thoracic Vertebrae Aged
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Infliximab trough levels and persistent vs transient antibodies measured early after induction predict long-term clinical remission in patients with inflammatory bowel disease.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver Nov 27, 2017
BACKGROUND: The use of therapeutic drug monitoring has been proposed as a useful tool in the management of patients with loss of response to biological therapy in patients with inflammatory bowel disease.
Young Adult Drug Resistance Adult Male Antibodies Time Factors Humans Crohn Disease Middle Aged Infliximab ROC Curve Prospective Studies Colitis, Ulcerative Gastrointestinal Agents Female Drug Monitoring Remission Induction Aged
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ZK DrugResist 2.0: A TextMiner to extract semantic relations of drug resistance from PubMed.

Journal of biomedical informatics Apr 4, 2017
Extracting useful knowledge from an unstructured textual data is a challenging task for biologists, since biomedical literature is growing exponentially on a daily basis. Building an automated method for such tasks is gaining much attention of resear...
Machine Learning PubMed Semantics Drug Resistance Humans
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Selection for anthelmintic resistant Teladorsagia circumcincta in pre-weaned lambs by treating their dams with long-acting moxidectin injection.

International journal for parasitology. Drugs and drug resistance Nov 10, 2015
Administration of long-acting anthelmintics to pregnant ewes prior to lambing is a common practice in New Zealand. Today, most of these products contain macrocyclic lactone (ML) actives, which because of their lipophilic nature, are detectable in the...
Anthelmintics Sheep Diseases Macrolides Drug Resistance Trichostrongyloidea Animals Trichostrongyloidiasis Lactation Female Animals, Suckling Sheep Nematode Infections Milk
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MATEPRED-A-SVM-Based Prediction Method for Multidrug And Toxin Extrusion (MATE) Proteins.

Computational biology and chemistry Jul 29, 2015
The growth and spread of drug resistance in bacteria have been well established in both mankind and beasts and thus is a serious public health concern. Due to the increasing problem of drug resistance, control of infectious diseases like diarrhea, pn...
Drug Resistance Organic Cation Transport Proteins Position-Specific Scoring Matrices Support Vector Machine Reproducibility of Results Amino Acids Dipeptides Hydrophobic and Hydrophilic Interactions
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Prevalence of aspirin resistance in Asian-Indian patients with stable coronary artery disease.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Jan 23, 2015
OBJECTIVE: To evaluate the prevalence of pharmacological resistance to aspirin therapy by measuring platelet functions using the technique of light transmission aggregometry.
India Treatment Outcome Coronary Angiography Tertiary Care Centers Aspirin Platelet Aggregation Inhibitors Drug Resistance Coronary Artery Disease Asian People Aged Adult Leukocyte Count Male Humans Platelet Aggregation Middle Aged Platelet Function Tests Prospective Studies Female
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DMGAT: predicting ncRNA-drug resistance associations based on diffusion map and heterogeneous graph attention network.

Briefings in bioinformatics Mar 4, 2025
Non-coding RNAs (ncRNAs) play crucial roles in drug resistance and sensitivity, making them important biomarkers and therapeutic targets. However, predicting ncRNA-drug associations is challenging due to issues such as dataset imbalance and sparsity,...
Algorithms Deep Learning Computational Biology Drug Resistance RNA, Untranslated Humans
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Predicting Secukinumab Fast-Responder Profile in Psoriatic Patients: Advanced Application of Artificial-Neural-Networks (ANNs).

Journal of drugs in dermatology : JDD Dec 1, 2020
BACKGROUND: Drug resistance to biologics in psoriasis therapy can occur – it may be acquired during a treatment or else present itself from the beginning. To date, no biomarkers are known that may reliably guide clinicians in predicting respons...
Humans Treatment Outcome Antibodies, Monoclonal, Humanized Prospective Studies Psoriasis Biomarkers Predictive Value of Tests Male Biological Products Prognosis Middle Aged Drug Resistance Deep Learning Severity of Illness Index Female Models, Immunological Pilot Projects Adult Time Factors Injections, Subcutaneous
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Artificial intelligence in drug combination therapy.

Briefings in bioinformatics Jul 19, 2019
Currently, the development of medicines for complex diseases requires the development of combination drug therapies. It is necessary because in many cases, one drug cannot target all necessary points of intervention. For example, in cancer therapy, a...
Neoplasms Deep Learning Computational Biology Logistic Models Gene Expression Regulation, Neoplastic Humans Neural Networks, Computer Artificial Intelligence Machine Learning Expert Systems Drug Therapy, Combination Drug Resistance Stochastic Processes Support Vector Machine Bayes Theorem Least-Squares Analysis Drug Interactions
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