AIMC Topic: Endothelial Cells

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Rapid Quantification of Microvessels of Three-Dimensional Blood-Brain Barrier Model Using Optical Coherence Tomography and Deep Learning Algorithm.

Biosensors Aug 15, 2023
The blood-brain barrier (BBB) is a selective barrier that controls the transport between the blood and neural tissue features and maintains brain homeostasis to protect the central nervous system (CNS). models can be useful to understand the role of...
Tomography, Optical Coherence Endothelial Cells Blood-Brain Barrier Microvessels Deep Learning Algorithms
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Deciphering ligand-receptor-mediated intercellular communication based on ensemble deep learning and the joint scoring strategy from single-cell transcriptomic data.

Computers in biology and medicine Jun 12, 2023
BACKGROUND: Cell-cell communication in a tumor microenvironment is vital to tumorigenesis, tumor progression and therapy. Intercellular communication inference helps understand molecular mechanisms of tumor growth, progression and metastasis.
Cell Communication Ligands Endothelial Cells Squamous Cell Carcinoma of Head and Neck Melanoma Head and Neck Neoplasms Tumor Microenvironment Deep Learning Sequence Analysis, RNA Transcriptome Humans
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Adaptive fuzzy control of drug delivery in cancer treatment using combination of chemotherapy and antiangiogenic therapy.

Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine Feb 11, 2023
This paper introduces the adaptive fuzzy control scheme as a promising control technique for cancer treatment from a theoretical point of view. A mathematical model describing the dynamics of tumor growth under the drug interventions of chemotherapy ...
Humans Computer Simulation Fuzzy Logic Neoplasms Endothelial Cells Models, Theoretical
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Mobile-CellNet: Automatic Segmentation of Corneal Endothelium Using an Efficient Hybrid Deep Learning Model.

Cornea Dec 12, 2022
PURPOSE: The corneal endothelium, the innermost layer of the human cornea, exhibits a morphology of predominantly hexagonal cells. These endothelial cells are believed to have limited regeneration capacity, and their density decreases over time. Endo...
Humans Cornea Deep Learning Endothelium, Corneal Cell Count Endothelial Cells
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Design and implementation of an adaptive fuzzy sliding mode controller for drug delivery in treatment of vascular cancer tumours and its optimisation using genetic algorithm tool.

IET systems biology Sep 30, 2022
In this paper, the side effects of drug therapy in the process of cancer treatment are reduced by designing two optimal non-linear controllers. The related gains of the designed controllers are optimised using genetic algorithm and simultaneously are...
Fuzzy Logic Endothelial Cells Humans Computer Simulation Neoplasms Algorithms
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Glycotherapy: A New Paradigm in Breast Cancer Research.

Biomolecules Mar 23, 2022
Breast cancer is an ancient disease recognized first by the Egyptians as early as 1600 BC. The first cancer-causing gene in a chicken tumor virus was found in 1970. The United States signed the National Cancer Act in 1971, authorizing federal funding...
Mice Tunicamycin Endothelial Cells Breast Neoplasms Humans Unfolded Protein Response Endoplasmic Reticulum Stress Animals Female Quality of Life
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Deep-learning-assisted Fourier transform imaging spectroscopy for hyperspectral fluorescence imaging.

Scientific reports Feb 15, 2022
Hyperspectral fluorescence imaging is widely used when multiple fluorescent probes with close emission peaks are required. In particular, Fourier transform imaging spectroscopy (FTIS) provides unrivaled spectral resolution; however, the imaging throu...
Pulmonary Artery Fluorescent Dyes Endothelial Cells Fourier Analysis Image Processing, Computer-Assisted Spectrometry, Fluorescence Neural Networks, Computer Deep Learning Cattle Animals
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Change patterns in the corneal sub-basal nerve and corneal aberrations in patients with dry eye disease: An artificial intelligence analysis.

Experimental eye research Dec 10, 2021
We aimed to investigate the change patterns in corneal sub-basal nerve morphology and corneal intrinsic aberrations in dry eye disease (DED). Our study included 229 eyes of 155 patients with DED and 40 eyes of 20 healthy control. We used the Oculus k...
Dry Eye Syndromes Cornea Humans Microscopy, Confocal Artificial Intelligence Endothelial Cells
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Soft robotic constrictor for in vitro modeling of dynamic tissue compression.

Scientific reports Aug 13, 2021
Here we present a microengineered soft-robotic in vitro platform developed by integrating a pneumatically regulated novel elastomeric actuator with primary culture of human cells. This system is capable of generating dynamic bending motion akin to th...
Robotics Tissue Engineering Endothelial Cells Compressive Strength Myocytes, Smooth Muscle In Vitro Techniques Neoplasm Invasiveness Fibroblasts Humans
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An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging.

Nature aging Jul 12, 2021
While many diseases of aging have been linked to the immunological system, immune metrics capable of identifying the most at-risk individuals are lacking. From the blood immunome of 1,001 individuals aged 8-96 years, we developed a deep-learning meth...
Immunosenescence Animals Frailty Humans Aging Endothelial Cells Mice Aged, 80 and over Deep Learning Multimorbidity Inflammation
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