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Differentiation between multiple sclerosis and neuromyelitis optica spectrum disorders by multiparametric quantitative MRI using convolutional neural network.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
Multiple sclerosis and neuromyelitis optica spectrum disorders are both neuroinflammatory diseases and have overlapping clinical manifestations. We developed a convolutional neural network model that differentiates between the two based on magnetic r...

A two-stage modeling approach for breast cancer survivability prediction.

International journal of medical informatics
BACKGROUND: Despite the increasing number of studies in breast cancer survival prediction, there is little attention put toward deceased patients and their survival lengths. Moreover, developing a model that is both accurate and interpretable remains...

Prediction of tau accumulation in prodromal Alzheimer's disease using an ensemble machine learning approach.

Scientific reports
We developed machine learning (ML) algorithms to predict abnormal tau accumulation among patients with prodromal AD. We recruited 64 patients with prodromal AD using the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset. Supervised ML approa...

Explaining decisions of graph convolutional neural networks: patient-specific molecular subnetworks responsible for metastasis prediction in breast cancer.

Genome medicine
BACKGROUND: Contemporary deep learning approaches show cutting-edge performance in a variety of complex prediction tasks. Nonetheless, the application of deep learning in healthcare remains limited since deep learning methods are often considered as ...

Using Machine Learning to Unravel the Value of Radiographic Features for the Classification of Bone Tumors.

BioMed research international
OBJECTIVES: To build and validate random forest (RF) models for the classification of bone tumors based on the conventional radiographic features of the lesion and patients' clinical characteristics, and identify the most essential features for the c...

Convolutional neural network for classifying primary liver cancer based on triple-phase CT and tumor marker information: a pilot study.

Japanese journal of radiology
PURPOSE: To develop convolutional neural network (CNN) models for differentiating intrahepatic cholangiocarcinoma (ICC) from hepatocellular carcinoma (HCC) and predicting histopathological grade of HCC.

How can the accuracy of SEEG be increased?-an analysis of the accuracy of multilobe-spanning SEEG electrodes based on a frameless stereotactic robot-assisted system.

Annals of palliative medicine
BACKGROUND: A frameless stereotactic robot-assisted system allows stereoelectroencephalography (SEEG) electrodes to span multiple lobes. As the angularity and length are increased, maintaining accuracy of the electrodes becomes more challenging. The ...

Accurate prediction of acute pancreatitis severity with integrative blood molecular measurements.

Aging
BACKGROUND: Early diagnosis of severe acute pancreatitis (SAP) is essential to minimize its mortality and improve prognosis. We aimed to develop an accurate and applicable machine learning predictive model based on routine clinical testing results fo...

Predictive model for the 5-year survival status of osteosarcoma patients based on the SEER database and XGBoost algorithm.

Scientific reports
Osteosarcoma is the most common bone malignancy, with the highest incidence in children and adolescents. Survival rate prediction is important for improving prognosis and planning therapy. However, there is still no prediction model with a high accur...

A machine learning approach to personalized dose adjustment of lamotrigine using noninvasive clinical parameters.

Scientific reports
The pharmacokinetic variability of lamotrigine (LTG) plays a significant role in its dosing requirements. Our goal here was to use noninvasive clinical parameters to predict the dose-adjusted concentrations (C/D ratio) of LTG based on machine learnin...