AIMC Topic: gamma-Aminobutyric Acid

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Intact metabolite spectrum mining by deep learning in proton magnetic resonance spectroscopy of the brain.

Magnetic resonance in medicine
PURPOSE: To develop a robust method for brain metabolite quantification in proton magnetic resonance spectroscopy ( H-MRS) using a convolutional neural network (CNN) that maps in vivo brain spectra that are typically degraded by low SNR, line broaden...

Extracellular GABA assisting in organizing dynamic cell assemblies to shorten reaction time to sensory stimulation.

Biological cybernetics
Until recently, glia, which exceeds the number of neurons, was considered to only have supportive roles in the central nervous system, providing homeostatic controls and metabolic supports. However, recent studies suggest that glia interacts with neu...

Improved Perceptual Learning by Control of Extracellular GABA Concentration by Astrocytic Gap Junctions.

Neural computation
Learning of sensory cues is believed to rely on synchronous pre- and postsynaptic neuronal firing. Evidence is mounting that such synchronicity is not merely caused by properties of the underlying neuronal network but could also depend on the integri...

Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway.

Scientific reports
The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorderĀ (OCD), a neuropsychiatric disorder ch...

Tonic regulation of stationary asynchronous firing of a neural network.

Journal of computational neuroscience
The impact of tonic conductance upon population activity was investigated. An extra tonic transmembrane current through GABA-activated extrasynaptic GABA -receptors was found to control stationary asynchronous firing both quantitatively and qualitat...

Optimization of culture conditions for gamma-aminobutyric acid production in fermented adzuki bean milk.

Journal of food and drug analysis
γ-Aminobutyric acid (GABA), a nonprotein amino acid, is widely distributed in nature and fulfills several physiological functions. In this study, various lactic acid strains commonly used to produce fermented milk products were inoculated into adzuki...

Reduction of Trial-to-Trial Perceptual Variability by Intracortical Tonic Inhibition.

Neural computation
Variability is a prominent characteristic of cognitive brain function. For instance, different trials of presentation of the same stimulus yield higher variability in its perception: subjects sometimes fail in perceiving the same stimulus. Perceptual...

GABA diffusion across neuronal columns for efficient sensory tuning.

Biological cybernetics
Synaptic (phasic) lateral inhibition between neuronal columns mediated by GABAergic interneurons is, in general, essential for primary sensory cortices to respond selectively to elemental features. We propose here a neural network model with a nonsyn...

Regulation of Local Ambient GABA Levels via Transporter-Mediated GABA Import and Export for Subliminal Learning.

Neural computation
Perception of supraliminal stimuli might in general be reflected in bursts of action potentials (spikes), and their memory traces could be formed through spike-timing-dependent plasticity (STDP). Memory traces for subliminal stimuli might be formed i...