AIMC Topic: gamma-Aminobutyric Acid
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Improved Perceptual Learning by Control of Extracellular GABA Concentration by Astrocytic Gap Junctions.
Neural computation
Oct 24, 2017
Learning of sensory cues is believed to rely on synchronous pre- and postsynaptic neuronal firing. Evidence is mounting that such synchronicity is not merely caused by properties of the underlying neuronal network but could also depend on the integri...
Global and local excitation and inhibition shape the dynamics of the cortico-striatal-thalamo-cortical pathway.
Scientific reports
Aug 8, 2017
The cortico-striatal-thalamo-cortical (CSTC) pathway is a brain circuit that controls movement execution, habit formation and reward. Hyperactivity in the CSTC pathway is involved in obsessive compulsive disorder (OCD), a neuropsychiatric disorder ch...
Tonic regulation of stationary asynchronous firing of a neural network.
Journal of computational neuroscience
May 16, 2017
The impact of tonic conductance upon population activity was investigated. An extra tonic transmembrane current through GABA-activated extrasynaptic GABA -receptors was found to control stationary asynchronous firing both quantitatively and qualitat...
Optimization of culture conditions for gamma-aminobutyric acid production in fermented adzuki bean milk.
Journal of food and drug analysis
Feb 13, 2017
γ-Aminobutyric acid (GABA), a nonprotein amino acid, is widely distributed in nature and fulfills several physiological functions. In this study, various lactic acid strains commonly used to produce fermented milk products were inoculated into adzuki...
Phantom motor execution facilitated by machine learning and augmented reality as treatment for phantom limb pain: a single group, clinical trial in patients with chronic intractable phantom limb pain.
Lancet (London, England)
Dec 2, 2016
BACKGROUND: Phantom limb pain is a debilitating condition for which no effective treatment has been found. We hypothesised that re-engagement of central and peripheral circuitry involved in motor execution could reduce phantom limb pain via competiti...
Treatment Outcome
Pain Measurement
Phantom Limb
Exercise Therapy
Gabapentin
Sweden
Games, Recreational
gamma-Aminobutyric Acid
Amines
Amputation, Surgical
Slovenia
Aged
Virtual Reality Exposure Therapy
Chronic Pain
Adult
Humans
Upper Extremity
Middle Aged
Cyclohexanecarboxylic Acids
Machine Learning
Reduction of Trial-to-Trial Perceptual Variability by Intracortical Tonic Inhibition.
Neural computation
Nov 24, 2015
Variability is a prominent characteristic of cognitive brain function. For instance, different trials of presentation of the same stimulus yield higher variability in its perception: subjects sometimes fail in perceiving the same stimulus. Perceptual...
GABA diffusion across neuronal columns for efficient sensory tuning.
Biological cybernetics
Jul 28, 2015
Synaptic (phasic) lateral inhibition between neuronal columns mediated by GABAergic interneurons is, in general, essential for primary sensory cortices to respond selectively to elemental features. We propose here a neural network model with a nonsyn...
Regulation of Local Ambient GABA Levels via Transporter-Mediated GABA Import and Export for Subliminal Learning.
Neural computation
Mar 16, 2015
Perception of supraliminal stimuli might in general be reflected in bursts of action potentials (spikes), and their memory traces could be formed through spike-timing-dependent plasticity (STDP). Memory traces for subliminal stimuli might be formed i...
Identifying responders to gabapentin for the treatment of alcohol use disorder: an exploratory machine learning approach.
Alcohol and alcoholism (Oxford, Oxfordshire)
Mar 25, 2025
BACKGROUND: Gabapentin, an anticonvulsant medication, has been proposed as a treatment for alcohol use disorder (AUD). A multisite study tested gabapentin enacarbil extended-release (GE-XR; 600 mg/twice a day), a prodrug formulation, combined with a ...
Understanding the role of astrocytic GABA in simulated neural networks.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Aug 1, 2016
Astrocytes actively influence the behavior of the surrounding neuronal network including changes of the synaptic plasticity and neuronal excitability. These dynamics are altered in diseases like Alzheimer's, where the release of the gliotransmitter G...
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