AIMC Topic: Gene Frequency

Clear Filters Showing 31 to 36 of 36 articles

Computationally Efficient Demographic History Inference from Allele Frequencies with Supervised Machine Learning.

Molecular biology and evolution
Inferring past demographic history of natural populations from genomic data is of central concern in many studies across research fields. Previously, our group had developed dadi, a widely used demographic history inference method based on the allele...

Exploitation of surrogate variables in random forests for unbiased analysis of mutual impact and importance of features.

Bioinformatics (Oxford, England)
MOTIVATION: Random forest is a popular machine learning approach for the analysis of high-dimensional data because it is flexible and provides variable importance measures for the selection of relevant features. However, the complex relationships bet...

Predicting Amyloid-β Levels in Amnestic Mild Cognitive Impairment Using Machine Learning Techniques.

Journal of Alzheimer's disease : JAD
BACKGROUND: Amyloid-β positivity (Aβ+) based on PET imaging is part of the enrollment criteria for many of the clinical trials of Alzheimer's disease (AD), particularly in trials for amyloid-targeted therapy. Predicting Aβ positivity prior to PET ima...

[HIGH FREQUENCY OF CYP2C19 ULTRARAPID METABOLIZERS IN RUSSIAN PATIENTS WITH PEPTIC ULCER].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology
INTRODUCTION: The main enzyme responsible for metabolism of proton pump inhibitors (PPI) is cytochrome P-4502C19 (CYP2C19). Among all CYP2C19 polymorphisms ulrarapid CYP2C19*17 allele plays an important role in clinical practice as in CYP2C19*17 alle...