In the mammalian brain, newly acquired memories depend on the hippocampus (HPC) for maintenance and recall, but over time, the neocortex takes over these functions, rendering memories HPC-independent. The process responsible for this transformation i...
IEEE journal of biomedical and health informatics
Dec 23, 2019
Delineation of mitochondria from electron microscopy (EM) images is crucial to investigate its morphology and distribution, which are directly linked to neural dysfunction. However, it is a challenging task due to the varied appearances, sizes and sh...
Alzheimer's disease (AD) is a progressive and irreversible brain degenerative disorder. Mild cognitive impairment (MCI) is a clinical precursor of AD. Although some treatments can delay its progression, no effective cures are available for AD. Accura...
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Dec 16, 2019
Understanding how the brain forms representations of structured information distributed in time is a challenging endeavour for the neuroscientific community, requiring computationally and neurobiologically informed approaches. The neural mechanisms f...
OBJECTIVE: Temporal lobe epilepsy is a common form of epilepsy that might be amenable to surgery. However, magnetic resonance imaging (MRI)-negative hippocampal sclerosis (HS) can hamper early diagnosis and surgical intervention for patients in clini...
A theory and model of spatial coordinate transforms in the dorsal visual system through the parietal cortex that enable an interface via posterior cingulate and related retrosplenial cortex to allocentric spatial representations in the primate hippoc...
The ability to rapidly assimilate new information is essential for survival in a dynamic environment. This requires experiences to be encoded alongside the contextual schemas in which they occur. Tse et al. (Science 316(5821):76-82, 2007) showed that...
Neural networks : the official journal of the International Neural Network Society
Oct 26, 2019
Complementary Learning Systems (CLS) theory suggests that the brain uses a 'neocortical' and a 'hippocampal' learning system to achieve complex behaviour. These two systems are complementary in that the 'neocortical' system relies on slow learning of...
Hippocampal volumetry is a critical biomarker of aging and dementia, and it is widely used as a predictor of cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms are (a) not publicly available,...
Gene and protein expressions are key determinants of cellular function. Neurons are the building blocks of brain circuits, yet the relationship between their molecular identity and the spatial distribution of their dendritic inputs and axonal outputs...
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