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Histological Techniques

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Deep learning links histology, molecular signatures and prognosis in cancer.

Nature cancer
Deep learning can be used to predict genomic alterations based on morphological features learned from digital histopathology. Two independent pan-cancer studies now show that automated learning from digital pathology slides and genomics can potential...

SAFRON: Stitching Across the Frontier Network for Generating Colorectal Cancer Histology Images.

Medical image analysis
Automated synthesis of histology images has several potential applications including the development of data-efficient deep learning algorithms. In the field of computational pathology, where histology images are large in size and visual context is c...

Non-invasive scoring of cellular atypia in keratinocyte cancers in 3D LC-OCT images using Deep Learning.

Scientific reports
Diagnosis based on histopathology for skin cancer detection is today's gold standard and relies on the presence or absence of biomarkers and cellular atypia. However it suffers drawbacks: it requires a strong expertise and is time-consuming. Moreover...

Nucleus classification in histology images using message passing network.

Medical image analysis
Identification of nuclear components in the histology landscape is an important step towards developing computational pathology tools for the profiling of tumor micro-environment. Most existing methods for the identification of such components are li...

Deep active learning for suggestive segmentation of biomedical image stacks via optimisation of Dice scores and traced boundary length.

Medical image analysis
Manual segmentation of stacks of 2D biomedical images (e.g., histology) is a time-consuming task which can be sped up with semi-automated techniques. In this article, we present a suggestive deep active learning framework that seeks to minimise the a...

A Cascaded Deep Learning Framework for Segmentation of Nuclei in Digital Histology Images.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Accurate segmentation of nuclei is an essential step in analysis of digital histology images for diagnostic and prognostic applications. Despite recent advances in automated frameworks for nuclei segmentation, this task is still challenging. Specific...

CS-CO: A Hybrid Self-Supervised Visual Representation Learning Method for H&E-stained Histopathological Images.

Medical image analysis
Visual representation extraction is a fundamental problem in the field of computational histopathology. Considering the powerful representation capacity of deep learning and the scarcity of annotations, self-supervised learning has emerged as a promi...

SONNET: A Self-Guided Ordinal Regression Neural Network for Segmentation and Classification of Nuclei in Large-Scale Multi-Tissue Histology Images.

IEEE journal of biomedical and health informatics
Automated nuclei segmentation and classification are the keys to analyze and understand the cellular characteristics and functionality, supporting computer-aided digital pathology in disease diagnosis. However, the task still remains challenging due ...

Identify Representative Samples by Conditional Random Field of Cancer Histology Images.

IEEE transactions on medical imaging
Pathology analysis is crucial to precise cancer diagnoses and the succeeding treatment plan as well. To detect abnormality in histopathology images with prevailing patch-based convolutional neural networks (CNNs), contextual information often serves ...