INTRODUCTION: Diabetes affects ~10% of the world's population and is rising. Treatment costs in the UK are ~15% of the NHS budget. Diabetes-related complications can be lowered through better evidence-based clinician management and patient self-manag...
OBJECTIVE: To develop and validate prediction models for peak oxygen uptake (VO₂peak) in patients with coronary heart disease (CHD) using submaximal cardiopulmonary exercise testing (CPET) indicators and deep learning methods.
The 22 Annual Meeting of the Association for Cancer Immunotherapy (CIMT) was held from May 12 to May 14, 2025, in Mainz, Germany. The event brought together 674 academic and clinical professionals from 27 countries across five continents. As a centra...
Biochemical and biophysical research communications
Oct 4, 2025
The extracellular matrix (ECM) is crucial in tuning cellular behavior, and quantifying cellular mechanical changes in response to ECM stimuli can help reveal the underlying physical mechanisms of cell-ECM interactions for a comprehensive understandin...
Journal of computer-aided molecular design
Oct 4, 2025
The traditional drug discovery process is often lengthy, costly, and characterized by a high failure rate. There is a pressing need for innovative strategies to optimize this process and improve the chances of identifying effective therapeutic candid...
This paper presents a trust-aware architecture for personalized digital health that combines user modeling, symbolic reasoning, and adaptive trust mechanisms. The proposed system uses Blueprint Personas to capture detailed patient profiles, including...
Poor oral bioavailability in most modern pharmaceuticals is primarily caused by poor aqueous solubility. Most NCEs (New Chemical Entities) and nearly 40% of drugs on the market fall into either Biopharmaceutical Classification System (BCS) class II o...
PURPOSE: Research related to pediatric bone age has gained substantial scholarly attention over recent decades, given its critical importance in monitoring growth and guiding clinical decision-making in children. This study aims to identify research ...
Journal of cancer research and clinical oncology
Oct 4, 2025
PURPOSE: The integration of artificial intelligence (AI) with hyperspectral imaging (HSI) offers a promising avenue for improving pre-therapeutic prognosis, a key factor in optimizing cancer treatment strategies. This study explores the potential of ...
BACKGROUND: Hemophagocytic lymphohistiocytosis (HLH) is associated with high mortality rates. This study was conducted to develop and validate a predictive model for adult HLH patients at high risk of six months mortality using machine learning (ML) ...
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