BACKGROUND: Bioactive natural products represent a vital resource for combating human diseases. However, their discovery often encounters multiple challenges. Bioactivity-guided isolation can yield bioactive compounds but are labor-intensive and have...
OBJECTIVE: This study aims to develop an objective and efficient diagnostic model for schizophrenia (SCZ) by integrating electroencephalogram (EEG) signals with deep learning techniques. Building on previous research, γ wave activity is selected as a...
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder. The role of protein post-translational modifications (PTMs), especially small ubiquitin-like modifier (SUMO) conjugation (SUMOylation), in PD pathogenesis remains unclear. T...
BACKGROUND: Sepsis is frequently combined with acute liver failure (ALF), a critical determinant in the mortality of septic patients. Pyroptosis is a significant form of programmed cell death that plays an important role in the inflammatory response....
BACKGROUND: Start loss variants are a class of genetic variants that affect the bases of the start codon, disrupting the normal translation initiation process and leading to protein deletions or the production of different proteins. Accurate assessme...
BMC medical informatics and decision making
Aug 8, 2025
BACKGROUND: Anti-programmed cell death protein 1 (PD-1)/programmed cell death ligand 1 (PD-L1) immunotherapy has revolutionized cancer treatment. However, it can cause immune-related adverse events, including acute kidney injury (AKI). Such adverse e...
Effective financial risk management in healthcare systems requires intelligent decision-making that balances treatment quality with cost efficiency. This paper proposes a novel hybrid framework that integrates reinforcement learning (RL) with knowled...
COVID-19 has posed a significant global health challenge, affecting individuals across all age groups. While extensive research has focused on adults, pediatric patients exhibit distinct clinical characteristics that necessitate specialized predictiv...
In clinical practice, early recognition of bacteremia leads to prognostic improvement. Recently, cell population data (CPD) from the Sysmex XN-series hematology analyzer has attracted attention as a new method for the early diagnosis of bacteremia, b...
Human metapneumovirus (hMPV) is a significant cause of respiratory illness, particularly in children, elderly individuals, and immunocompromised patients. Despite its clinical relevance, hMPV poses diagnostic challenges due to its symptom similarity ...
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