Humans

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Incorporating EBO-HSIC with SVM for Gene Selection Associated with Cervical Cancer Classification.

Journal of medical systems Oct 6, 2018
Microarray technology is utilized by the biologists, in order to compute the expression levels of thousands of genes. Cervical cancer classification utilizing gene expression data depends upon conventional supervised learning methods, wherein only la...
Humans Algorithms Fuzzy Logic Gene Expression Oligonucleotide Array Sequence Analysis Female Uterine Cervical Neoplasms Support Vector Machine
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3-D Quantification of Filopodia in Motile Cancer Cells.

IEEE transactions on medical imaging Oct 5, 2018
We present a 3D bioimage analysis workflow to quantitatively analyze single, actin-stained cells with filopodial protrusions of diverse structural and temporal attributes, such as number, length, thickness, level of branching, and lifetime, in time-l...
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Pseudopodia Lung Neoplasms Adenocarcinoma Cell Line Neural Networks, Computer Algorithms Neoplasms Spatio-Temporal Analysis Imaging, Three-Dimensional Image Processing, Computer-Assisted Humans
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Framing the challenges of artificial intelligence in medicine.

BMJ quality & safety Oct 5, 2018
Quality Control Humans Artificial Intelligence Delivery of Health Care Decision Support Systems, Clinical
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Application of electronic trigger tools to identify targets for improving diagnostic safety.

BMJ quality & safety Oct 5, 2018
Progress in reducing diagnostic errors remains slow partly due to poorly defined methods to identify errors, high-risk situations, and adverse events. Electronic trigger (e-trigger) tools, which mine vast amounts of patient data to identify signals i...
Natural Language Processing Safety Management Electronic Health Records Diagnostic Errors Risk Assessment Humans Algorithms Patient Safety
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PBMDR: A particle swarm optimization-based multifactor dimensionality reduction for the detection of multilocus interactions.

Journal of theoretical biology Oct 5, 2018
Studies on multilocus interactions have mainly investigated the associations between genetic variations from the related genes and histopathological tumor characteristics in patients. However, currently, the identification and characterization of sus...
Humans Algorithms Female Breast Neoplasms Genetic Predisposition to Disease Genetic Loci Polymorphism, Single Nucleotide Multifactor Dimensionality Reduction Genotype Genes, Neoplasm
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Dictionary Representations for Electrode Displacement Elastography.

IEEE transactions on ultrasonics, ferroelectrics, and frequency control Oct 5, 2018
Ultrasound electrode displacement elastography (EDE) has demonstrated the potential to monitor ablated regions in human patients after minimally invasive microwave ablation procedures. Displacement estimation for EDE is commonly plagued by decorrelat...
Elasticity Imaging Techniques Ablation Techniques Image Interpretation, Computer-Assisted Phantoms, Imaging Humans Algorithms Neoplasms Abdomen Supervised Machine Learning Electrodes
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A semi-supervised deep learning method based on stacked sparse auto-encoder for cancer prediction using RNA-seq data.

Computer methods and programs in biomedicine Oct 5, 2018
BACKGROUND AND OBJECTIVE: Cancer has become a complex health problem due to its high mortality. Over the past few decades, with the rapid development of the high-throughput sequencing technology and the application of various machine learning methods...
Pattern Recognition, Automated False Positive Reactions Gene Expression Regulation, Neoplastic Supervised Machine Learning RNA Deep Learning Humans Lung Neoplasms Software Sequence Analysis, RNA Breast Neoplasms Algorithms Female Male Reproducibility of Results Diagnosis, Computer-Assisted Stomach Neoplasms
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Deep learning and virtual drug screening.

Future medicinal chemistry Oct 5, 2018
Current drug development is still costly and slow given tremendous technological advancements in drug discovery and medicinal chemistry. Using machine learning (ML) to virtually screen compound libraries promises to fix this for generating drug leads...
Drug Discovery Deep Learning Ligands Humans Neural Networks, Computer
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The Rational Discovery of a Tau Aggregation Inhibitor.

Biochemistry Oct 5, 2018
Intrinsically disordered proteins play vital roles in biology, and their dysfunction contributes to many major disease states. These proteins remain challenging targets for rational ligand discovery or drug design because they are highly dynamic and ...
Ligands tau Proteins Protein Aggregates Humans Machine Learning Molecular Docking Simulation
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Comparison of 2 Natural Language Processing Methods for Identification of Bleeding Among Critically Ill Patients.

JAMA network open Oct 5, 2018
IMPORTANCE: To improve patient safety, health care systems need reliable methods to detect adverse events in large patient populations. Events are often described in clinical notes, rather than structured data, which make them difficult to identify o...
Support Vector Machine Aged Critical Illness Male Humans Natural Language Processing Electronic Health Records Aged, 80 and over Middle Aged Machine Learning Female Hemorrhage Sensitivity and Specificity ROC Curve
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