Humans

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Ab-initio conformational epitope structure prediction using genetic algorithm and SVM for vaccine design.

Computer methods and programs in biomedicine Oct 12, 2017
BACKGROUND AND OBJECTIVE: T-cell epitope structure identification is a significant challenging immunoinformatic problem within epitope-based vaccine design. Epitopes or antigenic peptides are a set of amino acids that bind with the Major Histocompati...
Humans Algorithms T-Lymphocytes Epitopes Vaccines ROC Curve Support Vector Machine Area Under Curve
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Use of automated learning techniques for predicting mandibular morphology in skeletal class I, II and III.

Forensic science international Oct 12, 2017
BACKGROUND: The prediction of the mandibular bone morphology in facial reconstruction for forensic purposes is usually performed considering a straight profile corresponding to skeletal class I, with application of linear and parametric analysis whic...
Adolescent Mandible Support Vector Machine Malocclusion Young Adult Regression Analysis Adult Anatomic Landmarks Humans Male Cephalometry Neural Networks, Computer Female
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Feature selection method based on support vector machine and shape analysis for high-throughput medical data.

Computers in biology and medicine Oct 12, 2017
Proteomics data analysis based on the mass-spectrometry technique can provide a powerful tool for early diagnosis of tumors and other diseases. It can be used for exploring the features that reflect the difference between samples from high-throughput...
Proteomics Databases, Factual Support Vector Machine Neoplasms High-Throughput Screening Assays Diagnosis, Computer-Assisted Principal Component Analysis Humans
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Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.

Stem cell reports Oct 12, 2017
Accurately predicting cardioactive effects of new molecular entities for therapeutics remains a daunting challenge. Immense research effort has been focused toward creating new screening platforms that utilize human pluripotent stem cell (hPSC)-deriv...
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Pluripotent Stem Cells Cardiotoxicity Myocardial Contraction Drug Evaluation, Preclinical High-Throughput Screening Assays Myocytes, Cardiac Cells, Cultured Cell Differentiation Humans Machine Learning
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A new semi-supervised learning model combined with Cox and SP-AFT models in cancer survival analysis.

Scientific reports Oct 12, 2017
Gene selection is an attractive and important task in cancer survival analysis. Most existing supervised learning methods can only use the labeled biological data, while the censored data (weakly labeled data) far more than the labeled data are ignor...
Proportional Hazards Models Supervised Machine Learning Survival Analysis Humans Algorithms Neoplasms
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Adaptive hybrid robotic system for rehabilitation of reaching movement after a brain injury: a usability study.

Journal of neuroengineering and rehabilitation Oct 12, 2017
BACKGROUND: Brain injury survivors often present upper-limb motor impairment affecting the execution of functional activities such as reaching. A currently active research line seeking to maximize upper-limb motor recovery after a brain injury, deals...
Humans Neural Networks, Computer Male Middle Aged Brain Injuries Retrospective Studies Female Adult Upper Extremity Stroke Rehabilitation Robotics Movement
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Prediction of Human Phenotype Ontology terms by means of hierarchical ensemble methods.

BMC bioinformatics Oct 12, 2017
BACKGROUND: The prediction of human gene-abnormal phenotype associations is a fundamental step toward the discovery of novel genes associated with human disorders, especially when no genes are known to be associated with a specific disease. In this c...
Molecular Sequence Annotation Humans Genetic Association Studies Algorithms Area Under Curve Phenotype Biological Ontologies ROC Curve
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Deep convolutional neural network with transfer learning for rectum toxicity prediction in cervical cancer radiotherapy: a feasibility study.

Physics in medicine and biology Oct 12, 2017
Better understanding of the dose-toxicity relationship is critical for safe dose escalation to improve local control in late-stage cervical cancer radiotherapy. In this study, we introduced a convolutional neural network (CNN) model to analyze rectum...
Retrospective Studies Female Uterine Cervical Neoplasms Humans Neural Networks, Computer Radiotherapy Planning, Computer-Assisted Brachytherapy Radiotherapy Dosage Rectum Feasibility Studies Organs at Risk
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Noninvasive Evaluation of Portal Hypertension Using a Supervised Learning Technique.

Journal of healthcare engineering Oct 12, 2017
Portal hypertension (PHT) is a key event in the evolution of different chronic liver diseases and leads to the morbidity and mortality of patients. The traditional reliable PHT evaluation method is a hepatic venous pressure gradient (HVPG) measuremen...
Supervised Machine Learning Humans Hypertension, Portal Diagnostic Tests, Routine Algorithms Portal Pressure Elasticity Imaging Techniques
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PICKLE 2.0: A human protein-protein interaction meta-database employing data integration via genetic information ontology.

PloS one Oct 12, 2017
It has been acknowledged that source databases recording experimentally supported human protein-protein interactions (PPIs) exhibit limited overlap. Thus, the reconstruction of a comprehensive PPI network requires appropriate integration of multiple ...
Gene Ontology Protein Interaction Mapping Humans Computational Biology Databases, Genetic Databases, Protein
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