AIMC Topic: Humans

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Flexible imputation toolkit for electronic health records.

Scientific reports
Missing data in electronic health records (EHRs) poses a significant challenge for analysis. This study introduces Pympute, a comprehensive Python package designed for efficient and robust missing value imputation for EHRs. Pympute's core algorithm, ...

Brain metabolic imaging-based model identifies cognitive stability in prodromal Alzheimer's disease.

Scientific reports
The recent approval of anti-amyloid pharmaceuticals for the treatment of Alzheimer's disease (AD) has created a pressing need for the ability to accurately identify optimal candidates for anti-amyloid therapy, specifically those with evidence for inc...

Construction and validation of a pain facial expressions dataset for critically ill children.

Scientific reports
Automatic pain assessment for non-communicative children is in high demand. However, the availability of related training datasets remains limited. This study focuses on creating a large-scale dataset of pain facial expressions specifically for Chine...

ConsensuSV-ONT - A modern method for accurate structural variant calling.

Scientific reports
Improvements in sequencing technology make the development of new tools for detection of structural variance more and more common. However, since the tools available for the long-read Oxford Nanopore sequencing are limited, and the selection of the o...

Extensible Immunofluorescence (ExIF) accessibly generates high-plexity datasets by integrating standard 4-plex imaging data.

Nature communications
Standard immunofluorescence imaging captures just ~4 molecular markers (4-plex) per cell, limiting dissection of complex biology. Inspired by multimodal omics-based data integration approaches, we propose an Extensible Immunofluorescence (ExIF) frame...

Hand and Elbow Nerve Entrapments: MR Imaging Evaluation.

Magnetic resonance imaging clinics of North America
Entrapment neuropathies are the result of compression, displacement, traction, or irritation of peripheral nerves due to anatomic and/or dynamic factors at specific anatomic sites. This article reviews the current magnetic resonance neurography techn...

Plexus and Peripheral Nerve MR Imaging: Advances and Applications: MR Neurography: Sequence Possibilities and Recent Advances.

Magnetic resonance imaging clinics of North America
MR neurography (MRN) has become a cornerstone in diagnosing and managing plexus and peripheral nerve disorders. This review explores recent advancements in MRN, emphasizing 3T imaging, coil selection, fat and vascular suppression strategies, and deep...

A Point Cloud Generation Network for Automatic Prediction of Postoperative Maxillofacial Soft Tissue.

Annals of biomedical engineering
PURPOSE: In the planning of maxillofacial surgery, accurately evaluating the postoperative soft tissue area is crucial. This allows doctors to provide patients with better morphological recovery while ensuring the restoration of normal functional are...

Discrimination of Respiratory Tract Infections by a Reduced Graphene Oxide Array Modified with Metal-Organic Frameworks and Metal Phthalocyanines.

ACS nano
As a prevalent clinical condition, it is critical to distinguish between bacterial and viral respiratory tract infections given their pivotal role in guiding appropriate pharmaceutical interventions and preventing antibiotic misuse. Exhaled breath (E...

The underlying molecular mechanisms and biomarkers of Hip fracture combined with deep vein thrombosis based on self sequencing bioinformatics analysis.

Journal of orthopaedic surgery and research
BACKGROUND: Thrombus formation is a severe complication in orthopedic surgery, significantly increasing mortality in patients with fractures. Therefore, identifying feature genes to determine thrombus presence in fracture surgeries is critical.