AIMC Topic: Humans

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Artificial Intelligence in Prostate Cancer Diagnosis on Magnetic Resonance Imaging: Time for a New PARADIGM.

European urology
Artificial intelligence (AI) may provide a solution for improving access to expert, timely, and accurate magnetic resonance imaging (MRI) interpretation. The PARADIGM trial will provide level 1 evidence on the role of AI in the diagnosis of prostate ...

Ovarian Cancer Detection in Ascites Cytology with Weakly Supervised Model on Nationwide Data Set.

The American journal of pathology
Conventional ascitic fluid cytology for detecting ovarian cancer is limited by its low sensitivity. To address this issue, this multicenter study developed patch image (PI)-based fully supervised convolutional neural network (CNN) models and clusteri...

Insulin resistance in type 1 diabetes is a key modulator of platelet hyperreactivity.

Diabetologia
AIMS/HYPOTHESIS: Individuals with type 1 diabetes are at increased cardiovascular risk, particularly in the presence of insulin resistance. A prothrombotic environment is believed to contribute to this risk but thrombotic pathways in type 1 diabetes ...

From Nuclear Receptors to GPCRs: a Deep Transfer Learning Approach for Enhanced Environmental Estrogen Recognition.

Environmental science & technology
Environmental estrogens (EEs), as typical endocrine-disrupting chemicals (EDCs), can bind to classic estrogen receptors (ERs) to induce genomic effects, as well as to G protein-coupled estrogen receptor (GPER) located on the membrane, thereby inducin...

Statistical algorithms for the analysis of deleterious genetic mutations.

Bio Systems
We present algorithms for model selection and parameter estimation concerning deleterious genetic mutations. Three models are considered: single gene mutation, double cross-effect mutations or no genetic cause. Each of these models include unknown pa...

Enhancing clinical decision support with physiological waveforms - A multimodal benchmark in emergency care.

Computers in biology and medicine
BACKGROUND: AI-driven prediction algorithms have the potential to enhance emergency medicine by enabling rapid and accurate decision-making regarding patient status and potential deterioration. However, the integration of multimodal data, including r...

A new computational cross-structure-activity relationship (C-SAR) approach applies to a selective HDAC6 inhibitor dataset for accelerated structure development.

Computers in biology and medicine
Several structure-activity relationship (SAR) methodologies have been developed for the research community to improve the potential activity of prototype structures. To accomplish this, Topliss proposed the Topliss tree and the Topliss Batchwise sche...

Improved integrated framework for flooded crop damage and recovery assessment: A multi-source earth observation and participatory mapping in Hadejia, Nigeria.

Journal of environmental management
Flooding has increasingly significant adverse effects on global food security, and there is a lack of a framework to effectively integrate remote sensing with survey data for accurate damage and recovery assessment. Also, optical satellite images for...

Standardizing a microbiome pipeline for body fluid identification from complex crime scene stains.

Applied and environmental microbiology
Recent advances in next-generation sequencing have opened up new possibilities for applying the human microbiome in various fields, including forensics. Researchers have capitalized on the site-specific microbial communities found in different parts ...

Integrative proteomic profiling of tumor and plasma extracellular vesicles identifies a diagnostic biomarker panel for colorectal cancer.

Cell reports. Medicine
The lack of reliable non-invasive biomarkers for early colorectal cancer (CRC) diagnosis underscores the need for improved diagnostic tools. Extracellular vesicles (EVs) have emerged as promising candidates for liquid-biopsy-based cancer monitoring. ...