AIMC Topic: Humans

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Micro- and Nano-Bots for Infection Control.

Advanced materials (Deerfield Beach, Fla.)
Medical micro- and nano-bots (MMBs and MNBs) have attracted a lot of attention owing to their precise motion for accessing difficult-to-reach areas in the body. These emerging tools offer the promise of non-invasive diagnostics and therapeutics for a...

Children on wheels: Identifying crash determinants using cluster correspondence analysis.

Accident; analysis and prevention
Child bicyclists (14 years old and younger) are among the most vulnerable road users, facing significant risks of crashes that often result in severe injuries or fatalities. This study aims to identify key factors influencing child bicyclist crashes ...

CLIC1 and IFITM2 expression in brain tissue correlates with cognitive impairment via immune dysregulation in sepsis and Alzheimer's disease.

International immunopharmacology
BACKGROUND: Sepsis, a life-threatening condition driven by dysregulated host responses to infection, is associated with long-term cognitive impairments resembling Alzheimer's disease (AD). However, the molecular mechanisms linking sepsis-induced cogn...

Artificial intelligence for the detection of interictal epileptiform discharges in EEG signals.

Revue neurologique
INTRODUCTION: Over the past decades, the integration of modern technologies - such as electronic health records, cloud computing, and artificial intelligence (AI) - has revolutionized the collection, storage, and analysis of medical data in neurology...

FetDTIAlign: A deep learning framework for affine and deformable registration of fetal brain dMRI.

NeuroImage
Diffusion MRI (dMRI) offers unique insights into the microstructure of fetal brain tissue in utero. Longitudinal and cross-sectional studies of fetal dMRI have the potential to reveal subtle but crucial changes associated with normal and abnormal neu...

Enhancing the understandings on SARS-CoV-2 main protease (M) mutants from molecular dynamics and machine learning.

International journal of biological macromolecules
While star drugs like Paxlovid have shown remarkable performance in combating SARS-CoV-2, we still face serious challenges such as viral mutants and resistance. In this study, we employ a computational framework combining molecular dynamics (MD) simu...

Artificial intelligence in central-peripheral interaction organ crosstalk: the future of drug discovery and clinical trials.

Pharmacological research
Drug discovery before the 20th century often focused on single genes, molecules, cells, or organs, failing to capture the complexity of biological systems. The emergence of protein-protein interaction network studies in 2001 marked a turning point an...

Peptide Property Prediction for Mass Spectrometry Using AI: An Introduction to State of the Art Models.

Proteomics
This review explores state of the art machine learning and deep learning models for peptide property prediction in mass spectrometry-based proteomics, including, but not limited to, models for predicting digestibility, retention time, charge state di...

Design of Multi-Cancer VOCs Profiling Platform via a Deep Learning-Assisted Sensing Library Screening Strategy.

Analytical chemistry
The efficiency of sensor arrays in parallel discrimination of multianalytes is fundamentally influenced by the quantity and performance of the sensor elements. The advent of combinational design has notably accelerated the generation of chemical libr...