AIMC Topic: In Situ Hybridization, Fluorescence

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The Use of Quantitative Digital Pathology to Measure Proteoglycan and Glycosaminoglycan Expression and Accumulation in Healthy and Diseased Tissues.

The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society Sep 16, 2020
Advances in reagents, methodologies, analytic platforms, and tools have resulted in a dramatic transformation of the research pathology laboratory. These advances have increased our ability to efficiently generate substantial volumes of data on the e...
Humans Artificial Intelligence Image Processing, Computer-Assisted Immunohistochemistry Proteoglycans Glycosaminoglycans In Situ Hybridization, Fluorescence
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Development and application of Peptide Nucleic Acid Fluorescence in situ Hybridization for the specific detection of Listeria monocytogenes.

Food microbiology Dec 15, 2018
Listeria monocytogenes is one of the most important foodborne pathogens due to the high hospitalization and mortality rates associated to an outbreak. Several new molecular methods that accelerate the identification of L. monocytogenes have been deve...
Nucleic Acid Probes Food Microbiology Sensitivity and Specificity Peptide Nucleic Acids Listeria monocytogenes Reagent Kits, Diagnostic Animals In Situ Hybridization, Fluorescence Food Contamination
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Semantic segmentation of mFISH images using convolutional networks.

Cytometry. Part A : the journal of the International Society for Analytical Cytology Apr 30, 2018
Multicolor in situ hybridization (mFISH) is a karyotyping technique used to detect major chromosomal alterations using fluorescent probes and imaging techniques. Manual interpretation of mFISH images is a time consuming step that can be automated usi...
Image Processing, Computer-Assisted In Situ Hybridization, Fluorescence Semantics Neural Networks, Computer Machine Learning Databases, Factual
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De novo prediction of human chromosome structures: Epigenetic marking patterns encode genome architecture.

Proceedings of the National Academy of Sciences of the United States of America Oct 31, 2017
Inside the cell nucleus, genomes fold into organized structures that are characteristic of cell type. Here, we show that this chromatin architecture can be predicted de novo using epigenetic data derived from chromatin immunoprecipitation-sequencing ...
Animals Epigenesis, Genetic In Situ Hybridization, Fluorescence Molecular Conformation Thermodynamics Humans Cell Nucleus Neural Networks, Computer Genome, Human Phase Transition Chromatin Chromosomes, Human
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Artificial Intelligence for the Evaluation of Operational Parameters Influencing Nitrification and Nitrifiers in an Activated Sludge Process.

Microbial ecology Feb 23, 2016
Nitrification at a full-scale activated sludge plant treating municipal wastewater was monitored over a period of 237 days. A combination of fluorescent in situ hybridization (FISH) and quantitative real-time polymerase chain reaction (qPCR) were use...
Artificial Intelligence DNA, Bacterial Models, Theoretical In Situ Hybridization, Fluorescence Nitrobacter Sewage Ammonia Waste Management Temperature Nitrification Real-Time Polymerase Chain Reaction Bacteria
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Enhancing HER2 testing in breast cancer: predicting fluorescence in situ hybridization (FISH) scores from immunohistochemistry images via deep learning.

The journal of pathology. Clinical research Mar 1, 2025
Breast cancer affects millions globally, necessitating precise biomarker testing for effective treatment. HER2 testing is crucial for guiding therapy, particularly with novel antibody-drug conjugates (ADCs) like trastuzumab deruxtecan, which shows pr...
Humans Female Predictive Value of Tests In Situ Hybridization, Fluorescence Immunohistochemistry Receptor, ErbB-2 Breast Neoplasms Biomarkers, Tumor Deep Learning
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Accurate single-molecule spot detection for image-based spatial transcriptomics with weakly supervised deep learning.

Cell systems May 15, 2024
Image-based spatial transcriptomics methods enable transcriptome-scale gene expression measurements with spatial information but require complex, manually tuned analysis pipelines. We present Polaris, an analysis pipeline for image-based spatial tran...
Single Molecule Imaging Image Processing, Computer-Assisted Supervised Machine Learning In Situ Hybridization, Fluorescence Humans Software Animals Deep Learning Single-Cell Analysis Gene Expression Profiling Transcriptome
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Artificial intelligence technologies empowering identification of novel diagnostic molecular markers in gastric cancer.

Indian journal of pathology & microbiology Jun 1, 2021
In recent clinical practice the molecular diagnostics have been significantly empowered and upgraded by the use of Artificial Intelligence and its assisted technologies. The use of Machine leaning and Deep Learning Neural network architectures have b...
Humans Artificial Intelligence Algorithms Molecular Diagnostic Techniques Stomach Neoplasms In Situ Hybridization, Fluorescence Biomarkers, Tumor Immunohistochemistry India
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DL-CNV: A deep learning method for identifying copy number variations based on next generation target sequencing.

Mathematical biosciences and engineering : MBE Sep 30, 2019
Copy number variations (CNVs) play an important role in many types of cancer. With the rapid development of next generation sequencing (NGS) techniques, many methods for detecting CNVs of a single sample have emerged: (i) require genome-wide data of ...
False Positive Reactions Exons Proto-Oncogene Proteins c-met DNA Copy Number Variations Area Under Curve High-Throughput Nucleotide Sequencing In Situ Hybridization, Fluorescence Receptor, ErbB-2 Genome, Human ROC Curve Lung Neoplasms Carcinoma, Non-Small-Cell Lung Sensitivity and Specificity Deep Learning Databases, Factual Genome-Wide Association Study Reproducibility of Results Humans Algorithms
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[Feasibility Study for Storage and Re-Utilization of Circulating Tumor Cells (CTCs)].

Rinsho byori. The Japanese journal of clinical pathology Oct 1, 2015
BACKGROUND: In this era of precision medicine, monitoring patients requires not only real time but also longitudinal sequence of samples at various time points. Based on this background, we focused on conditioned circumstances on fixation and storage...
In Situ Hybridization, Fluorescence Humans Specimen Handling Neoplastic Cells, Circulating Cell Line, Tumor Feasibility Studies Lung Neoplasms Cytological Techniques
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