AIMC Topic: Interneurons

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Microglial pruning of glycinergic synapses disinhibits spinal PKCĪ³ interneurons to drive pain hypersensitivity in mice.

Science translational medicine Jun 18, 2025
Microglial activation is linked to neuroinflammation in neuropathic pain. Recently, microglia-mediated synaptic pruning has received mounting attention. However, the exact role of spinal microglia in modulating neuropathic pain-associated neural circ...
Mice Mice, Inbred C57BL Microglia Glycine Protein Kinase C Animals Synapses Apolipoproteins E Male Spinal Cord Interneurons Neuralgia Complement C1q Hyperalgesia
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A deep learning strategy to identify cell types across species from high-density extracellular recordings.

Cell Feb 28, 2025
High-density probes allow electrophysiological recordings from many neurons simultaneously across entire brain circuits but fail to reveal cell type. Here, we develop a strategy to identify cell types from extracellular recordings in awake animals an...
Purkinje Cells Mice Rats Mice, Inbred C57BL Neurons Cerebellum Interneurons Optogenetics Animals Male Deep Learning
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Memristive Circuit Implementation of Caenorhabditis Elegans Mechanism for Neuromorphic Computing.

IEEE transactions on neural networks and learning systems Sep 3, 2024
To overcome the energy efficiency bottleneck of the von Neumann architecture and scaling limit of silicon transistors, an emerging but promising solution is neuromorphic computing, a new computing paradigm inspired by how biological neural networks h...
Models, Neurological Robotics Neurons Locomotion Neural Networks, Computer Animals Motor Neurons Nerve Net Caenorhabditis elegans Interneurons
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Flexible gating between subspaces in a neural network model of internally guided task switching.

Nature communications Aug 1, 2024
Behavioral flexibility relies on the brain's ability to switch rapidly between multiple tasks, even when the task rule is not explicitly cued but must be inferred through trial and error. The underlying neural circuit mechanism remains poorly underst...
Animals Models, Neurological Neurons Nerve Net Humans Neural Networks, Computer Brain Interneurons
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Coordination of top-down influence on V1 responses by interneurons and brain rhythms.

Bio Systems Jun 15, 2021
Top-down processing in neocortex underlies functions such as prediction, expectation, and attention. Visual systems have much feedback connection that carries information of behavioral context. Top-down signals along feedback pathways modulate the re...
Haplorhini Photic Stimulation Visual Perception Interneurons Visual Cortex Beta Rhythm Gamma Rhythm Neural Networks, Computer Animals Psychomotor Performance
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The CPGs for Limbed Locomotion-Facts and Fiction.

International journal of molecular sciences May 30, 2021
The neuronal networks that generate locomotion are well understood in swimming animals such as the lamprey, zebrafish and tadpole. The networks controlling locomotion in tetrapods remain, however, still enigmatic with an intricate motor pattern requi...
Lampreys Central Pattern Generators Motor Neurons Rodentia Zebrafish Spinal Cord Cats Computer Simulation Locomotion Animals Extremities Larva Motor Activity Humans Muscle, Skeletal Interneurons Neural Networks, Computer
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Modulation of the dynamics of cerebellar Purkinje cells through the interaction of excitatory and inhibitory feedforward pathways.

PLoS computational biology Feb 10, 2021
The dynamics of cerebellar neuronal networks is controlled by the underlying building blocks of neurons and synapses between them. For which, the computation of Purkinje cells (PCs), the only output cells of the cerebellar cortex, is implemented thro...
Synapses Neural Pathways Normal Distribution Synaptic Transmission Humans Interneurons Purkinje Cells Neural Networks, Computer Excitatory Postsynaptic Potentials Computer Simulation Models, Neurological Cerebellar Cortex Animals Action Potentials Signal Transduction Neurons Neuronal Plasticity Cerebellum
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Empirically constrained network models for contrast-dependent modulation of gamma rhythm in V1.

NeuroImage Jan 15, 2021
Gamma oscillations are thought to play a key role in neuronal network function and neuronal communication, yet the underlying generating mechanisms have not been fully elucidated to date. At least partly, this may be due to the fact that even in simp...
Neural Networks, Computer Databases, Factual Gamma Rhythm Animals Action Potentials Haplorhini Interneurons Pyramidal Cells
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Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling.

Frontiers in neural circuits Dec 23, 2020
The mechanisms involved in generation of rhythmic locomotor activity in the mammalian spinal cord remain poorly understood. These mechanisms supposedly rely on both intrinsic properties of constituting neurons and interactions between them. A subset ...
Interneurons Spinal Cord Motor Neurons Neural Networks, Computer Locomotion Animals Nerve Net Synapses Motor Activity
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Divisive gain modulation enables flexible and rapid entrainment in a neocortical microcircuit model.

Journal of neurophysiology Feb 5, 2020
Neocortical circuits exhibit a rich dynamic repertoire, and their ability to achieve entrainment (adjustment of their frequency to match the input frequency) is thought to support many cognitive functions and indicate functional flexibility. Although...
Interneurons Neural Inhibition Neural Networks, Computer Humans Neocortex Animals Models, Neurological Nerve Net
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