AIMC Topic: Ischemic Stroke

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Clinical trials and advanced MRI techniques with stem cell therapy for ischemic stroke: present and future perspectives.

Journal of translational medicine
Ischemic stroke remains a leading cause of disability and mortality worldwide. Currently, there are no effective therapeutic strategies to promote post-stroke nerve repair and regeneration in clinical practice. Stem cells, characterized by self-renew...

Characterization of SPTLC2 as a key driver promoting microglial activation and energy metabolism reprogramming after ischemic stroke through bulk and single-cell analyses combined with experimental validation.

Cell biology and toxicology
BACKGROUND: Ischemic stroke (IS) stands as a principal contributor to high rates of sickness and death. The condition's pathological development is complicated, featuring mechanisms like mitochondrial impairment and the activation of microglial cells...

An efficient deep learning network for brain stroke detection using salp shuffled shepherded optimization.

Scientific reports
Brain strokes (BS) are potentially life-threatening cerebrovascular conditions and the second highest contributor to mortality. They include hemorrhagic and ischemic strokes, which vary greatly in size, shape, and location, posing significant challen...

Automated deep U-Net model for ischemic stroke lesion segmentation in the sub-acute phase.

Scientific reports
Manual segmentation of sub-acute ischemic stroke lesions in fluid-attenuated inversion recovery magnetic resonance imaging (FLAIR MRI) is time-consuming and subject to inter-observer variability, limiting clinical workflow efficiency. To develop and ...

Mapping neutrophil fate and function in ischemic stroke: A single-cell roadmap for translational insights.

Biochemical and biophysical research communications
BACKGROUND: Ischemic stroke (IS) accounts for 71 % of all strokes, whose diagnosis and prognosis require further exploration. Neutrophil extracellular traps (NETs) are produced by neutrophils, and there is already evidence that NETs play a role in IS...

Quercetagetin alleviates ischemic stroke injury by preserving macrophage/microglia homeostasis via inhibiting ACP5.

Phytomedicine : international journal of phytotherapy and phytopharmacology
BACKGROUND: The proinflammatory response triggered by macrophages/microglia plays a crucial role in the prognosis of acute ischemic stroke (AIS). Identifying novel targets to regulate the homeostasis of these cells is essential. Developing therapeuti...

Effects of walking training with and without a robot and standard care on clinical and mobility outcomes: A randomized clinical trial in acute ischemic stroke patients.

Experimental gerontology
BACKGROUND: Stroke incidence rises with age. A stroke can severely affect walking ability, requiring therapy. Robot-assisted walking therapy (ROB) has been advocated as one form of walking rehabilitation in stroke patients. However, its comparative e...

Development of a deep learning method to identify acute ischaemic stroke lesions on brain CT.

Stroke and vascular neurology
BACKGROUND: CT is commonly used to image patients with ischaemic stroke but radiologist interpretation may be delayed. Machine learning techniques can provide rapid automated CT assessment but are usually developed from annotated images which necessa...

Factors that influence technophobia in Chinese older patients with ischemic stroke: a cross-sectional survey.

BMC geriatrics
BACKGROUND: Older patients with ischemic stroke often have a large number of medical needs, technophobia refers to the irrational anxiety and fear of digital technologies such as mobile communication equipment, artificial intelligence and robots, res...

Age-related variation in hemoglobin glycation index and stroke mortality: mediation and machine learning in a cohort study.

Scientific reports
To investigate the associations between both age and the hemoglobin glycation index (HGI) and the 30-day and 1-year mortality in ischemic stroke (IS) patients and to analyze the mediating effect of the HGI on the relationship between age and mortalit...