AIMC Topic: Ischemic Stroke
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Multitarget Natural Compounds for Ischemic Stroke Treatment: Integration of Deep Learning Prediction and Experimental Validation.
Journal of chemical information and modeling
Mar 14, 2025
Ischemic stroke's complex pathophysiology demands therapeutic approaches targeting multiple pathways simultaneously, yet current treatments remain limited. We developed an innovative drug discovery pipeline combining a deep learning approach with exp...
Development and validation of an interpretable machine learning model for predicting in-hospital mortality for ischemic stroke patients in ICU.
International journal of medical informatics
Mar 9, 2025
BACKGROUND: Timely and accurate outcome prediction is essential for clinical decision-making for ischemic stroke patients in the intensive care unit (ICU). However, the interpretation and translation of predictive models into clinical applications ar...
Deep Learning Enhanced Near Infrared-II Imaging and Image-Guided Small Interfering Ribonucleic Acid Therapy of Ischemic Stroke.
ACS nano
Mar 5, 2025
Small interfering RNA (siRNA) targeting the NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome has emerged as a promising therapeutic strategy to mitigate infarct volume and brain injury following ischemic stroke. However, the cl...
Deep Learning-Based ASPECTS Algorithm Enhances Reader Performance and Reduces Interpretation Time.
AJNR. American journal of neuroradiology
Mar 4, 2025
BACKGROUND AND PURPOSE: ASPECTS is a long-standing and well-documented selection criterion for acute ischemic stroke treatment; however, the interpretation of ASPECTS is a challenging and time-consuming task for physicians with notable interobserver ...
Diffusion-Weighted Imaging-Based Radiomics Features and Machine Learning Method to Predict the 90-Day Prognosis in Patients With Acute Ischemic Stroke.
The neurologist
Mar 1, 2025
OBJECTIVES: The evaluation of the prognosis of patients with acute ischemic stroke (AIS) is of great significance in clinical practice. We aim to evaluate the feasibility and effectiveness of diffusion-weighted imaging (DWI) image-based radiomics fea...
Deep Learning-Assisted Diagnosis of Malignant Cerebral Edema Following Endovascular Thrombectomy.
Academic radiology
Feb 28, 2025
BACKGROUND: Malignant cerebral edema (MCE) is a significant complication following endovascular thrombectomy (EVT) in the treatment of acute ischemic stroke. This study aimed to develop and validate a deep learning-assisted diagnosis model based on t...
Machine learning analysis of gene expression profiles of pyroptosis-related differentially expressed genes in ischemic stroke revealed potential targets for drug repurposing.
Scientific reports
Feb 27, 2025
The relationship between ischemic stroke (IS) and pyroptosis centers on the inflammatory response elicited by cerebral tissue damage during an ischemic stroke event. However, an in-depth mechanistic understanding of their connection remains limited. ...
Traditional and machine learning models for predicting haemorrhagic transformation in ischaemic stroke: a systematic review and meta-analysis.
Systematic reviews
Feb 22, 2025
BACKGROUND: Haemorrhagic transformation (HT) is a severe complication after ischaemic stroke, but identifying patients at high risks remains challenging. Although numerous prediction models have been developed for HT following thrombolysis, thrombect...
Deep learning-based classification of diffusion-weighted imaging-fluid-attenuated inversion recovery mismatch.
Scientific reports
Feb 18, 2025
The presence of a diffusion-weighted imaging (DWI)-fluid-attenuated inversion recovery (FLAIR) mismatch holds potential value in identifying candidates for recanalization treatment. However, the visual assessment of DWI-FLAIR mismatch is subject to l...
Deep learning on pre-procedural computed tomography and clinical data predicts outcome following stroke thrombectomy.
Journal of neurointerventional surgery
Feb 14, 2025
BACKGROUND: Deep learning using clinical and imaging data may improve pre-treatment prognostication in ischemic stroke patients undergoing endovascular thrombectomy (EVT).
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