AIMC Topic: Kidney

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Identification of lipid metabolism-associated biomarkers in lupus nephritis by SVM model and therapeutic potential of Alisol B 23-acetate.

Gene
Systemic lupus erythematosus (SLE), a multifaceted autoimmune disorder, has lupus nephritis (LN) as one of its grave complications and is strongly associated with dyslipidemia. This investigation sought to delineate renal-specific lipid metabolism-re...

Estimation of postmortem interval under different ambient temperatures based on multi-organ metabolomics and machine learning algorithm.

International journal of legal medicine
In forensic practice, the estimation of postmortem interval has been a persistent challenge. Recently, there has been an increasing utilization of metabolomics techniques combined with machine learning methods for postmortem interval estimation. When...

Federated Learning for Renal Tumor Segmentation and Classification on Multi-Center MRI Dataset.

Journal of magnetic resonance imaging : JMRI
BACKGROUND: Deep learning (DL) models for accurate renal tumor characterization may benefit from multi-center datasets for improved generalizability; however, data-sharing constraints necessitate privacy-preserving solutions like federated learning (...

Discriminating Clear Cell From Non-Clear Cell Renal Cell Carcinoma: A Machine Learning Approach Using Contrast-enhanced Ultrasound Radiomics.

Ultrasound in medicine & biology
OBJECTIVE: The aim of this investigation is to assess the clinical usefulness of a machine learning model using contrast-enhanced ultrasound (CEUS) radiomics in discriminating clear cell renal cell carcinoma (ccRCC) from non-ccRCC.

Multiple omics-based machine learning reveals specific macrophage sub-clusters in renal ischemia-reperfusion injury and constructs predictive models for transplant outcomes.

Computational biology and chemistry
BACKGROUND: Ischemia-reperfusion injury (IRI) is closely associated with numerous severe postoperative complications, including acute rejection, delayed graft function (DGF) and graft failure. Macrophages are central to modulating the aseptic inflamm...

AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys.

Structure (London, England : 1993)
In this issue of Structure, Chang et al. combined deep-learning cryoelectron microscopy (cryo-EM) particle picking and heterogeneous refinement to obtain structures of human uromodulin filament lattices that were isolated from urine samples. This wor...

From planning to prognosis: predicting renal function after minimally-invasive partial nephrectomy with artificial intelligence.

Minerva urology and nephrology
This study presents a machine learning model to predict renal function decline following minimally-invasive partial nephrectomy. Using a dataset of 556 patients treated between 2015 and 2023, the model incorporated patient, tumor, and intraoperative ...

Model Systems of Chronic Kidney Disease: A Detailed Overview and Recent Advances.

Journal of biochemical and molecular toxicology
Experimental model systems, especially animal models, are indispensable tools to study human diseases and to develop new therapeutics. Chronic kidney disease (CKD) is a major global health problem having significantly higher rate of morbidity and mor...

Deep Learning Algorithms to Predict Differential Renal Function <40% in Unilateral Hydronephrosis Based on Key Parameters of Urinary Tract Ultrasound.

Urology
OBJECTIVE: To identify the correlation between ultrasound findings and the incidence of differential renal function (DRF) <40%, we conducted an analysis of the key parameters of urinary tract ultrasound in children with unilateral hydronephrosis. For...