AIMC Topic: Klebsiella Infections

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Machine-learning-based risk assessment tool to rule out empirical use of ESBL-targeted therapy in endemic areas.

The Journal of hospital infection Apr 27, 2024
BACKGROUND: Antimicrobial stewardship focuses on identifying patients who require extended-spectrum beta-lactamase (ESBL)-targeted therapy. 'Rule-in' tools have been researched extensively in areas of low endemicity; however, such tools are inadequat...
beta-Lactamases Antimicrobial Stewardship beta-Lactam Resistance Klebsiella pneumoniae Klebsiella Infections Escherichia coli Escherichia coli Infections Anti-Bacterial Agents Female Aged Aged, 80 and over Adult Male Middle Aged Risk Assessment Humans Machine Learning
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Identification of antibiotic resistance and virulence-encoding factors in Klebsiella pneumoniae by Raman spectroscopy and deep learning.

Microbial biotechnology Nov 29, 2021
Klebsiella pneumoniae has become the number one bacterial pathogen that causes high mortality in clinical settings worldwide. Clinical K. pneumoniae strains with carbapenem resistance and/or hypervirulent phenotypes cause higher mortality comparing w...
Virulence Factors Virulence Humans Klebsiella pneumoniae Anti-Bacterial Agents Klebsiella Infections Deep Learning Spectrum Analysis, Raman Drug Resistance, Microbial
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Accelerated antimicrobial discovery via deep generative models and molecular dynamics simulations.

Nature biomedical engineering Mar 11, 2021
The de novo design of antimicrobial therapeutics involves the exploration of a vast chemical repertoire to find compounds with broad-spectrum potency and low toxicity. Here, we report an efficient computational method for the generation of antimicrob...
Anti-Bacterial Agents Drug Resistance, Bacterial Female Animals Drug Design Drug Discovery Antimicrobial Cationic Peptides Structure-Activity Relationship Molecular Dynamics Simulation Amino Acid Sequence Pseudomonas aeruginosa Acinetobacter baumannii Klebsiella Infections Escherichia coli Staphylococcus aureus Mice, Inbred BALB C Deep Learning Microbial Sensitivity Tests Mice Klebsiella pneumoniae
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Detection of carbapenem-resistant Klebsiella pneumoniae on the basis of matrix-assisted laser desorption ionization time-of-flight mass spectrometry by using supervised machine learning approach.

PloS one Feb 6, 2020
BACKGROUND: Carbapenem-resistant Klebsiella pneumoniae (CRKP) is emerging as a significant pathogen causing healthcare-associated infections. Matrix-assisted laser desorption/ionisation mass spectrometry time-of-flight mass spectrometry (MALDI-TOF MS...
Carbapenem-Resistant Enterobacteriaceae Random Amplified Polymorphic DNA Technique Supervised Machine Learning Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Carbapenems Cross Infection Klebsiella pneumoniae DNA, Bacterial Klebsiella Infections Predictive Value of Tests Humans Algorithms Anti-Bacterial Agents Microbial Sensitivity Tests
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In vitro activity of flomoxef against extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in Korea.

Diagnostic microbiology and infectious disease Nov 26, 2018
To find an alternative regimen for the treatment of extended-spectrum β-lactamase (EBSL)-producing Enterobacteriaceae infections, we examined the in vitro activity of flomoxef against Escherichia coli and Klebsiella pneumoniae having CTX-M-1 group an...
Hospitals, University Cephalosporins Escherichia coli Proteins Klebsiella Infections Korea Humans Escherichia coli Anti-Bacterial Agents Escherichia coli Infections Microbial Sensitivity Tests beta-Lactamases Klebsiella pneumoniae
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Monitoring of antimicrobial susceptibility of udder pathogens recovered from cases of clinical mastitis in dairy cows across Europe: VetPath results.

Veterinary microbiology Nov 21, 2017
VetPath is an ongoing pan-European antimicrobial susceptibility monitoring programme collecting pathogens from diseased cattle, pigs and poultry not recently treated with antibiotics. Non-duplicate milk samples were collected from cows with acute cli...
Europe Escherichia coli Infections Streptococcal Infections Klebsiella Microbial Sensitivity Tests Cattle Klebsiella Infections Escherichia coli Drug Resistance, Bacterial Anti-Infective Agents Mastitis, Bovine Female Dairying Animals Mammary Glands, Animal Streptococcus
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Discrimination of Klebsiella pneumoniae and Klebsiella quasipneumoniae by MALDI-TOF Mass Spectrometry Coupled With Machine Learning.

MicrobiologyOpen Aug 1, 2025
Klebsiella species, including Klebsiella pneumoniae and Klebsiella quasipneumoniae, present significant challenges in clinical microbiology due to their genetic similarity, which complicates accurate species identification using established methods, ...
Klebsiella Infections Lipids Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Klebsiella Bacterial Typing Techniques Humans Machine Learning Biomarkers Klebsiella pneumoniae
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Decoding virulence and resistance in Klebsiella pneumoniae: Pharmacological insights, immunological dynamics, and in silico therapeutic strategies.

Microbial pathogenesis Aug 1, 2025
Klebsiella pneumoniae (K. pneumoniae) has become a serious global health concern due to its rising virulence and antibiotic resistance. As one of the leading members of ESKAPE pathogens, it plays a major role in a wide range of infections that cause ...
Humans Drug Resistance, Multiple, Bacterial Klebsiella pneumoniae Klebsiella Infections Virulence Factors Virulence Anti-Bacterial Agents Drug Resistance, Bacterial Computer Simulation Drug Discovery beta-Lactamases Bacterial Vaccines Immune Evasion
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Real-time FT-IR typing of Klebsiella pneumoniae: a flexible and rapid approach for outbreak detection and infection control.

The Journal of antimicrobial chemotherapy Jul 1, 2025
BACKGROUND: Expansion of carbapenemase-producing Klebsiella pneumoniae (CP-Kp) is driven by within-hospital transmission, requiring timely typing data for effective infection control.
Klebsiella Infections Spectroscopy, Fourier Transform Infrared Sensitivity and Specificity Cross Infection Multilocus Sequence Typing Disease Outbreaks Infection Control Portugal Klebsiella pneumoniae Bacterial Typing Techniques Humans
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Rapid Identification and Typing of Carbapenem-Resistant Klebsiella pneumoniae Using MALDI-TOF MS and Machine Learning.

Microbial biotechnology Jun 1, 2025
Use matrix-assisted laser desorption ionisation time-of-flight mass spectrometry (MALDI-TOF MS) to screen the specific mass peaks of carbapenem-resistant Klebsiella pneumoniae (CRKP), compare the differences in spectrum peaks between intestinal and b...
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Carbapenems Bacterial Typing Techniques Carbapenem-Resistant Enterobacteriaceae Sensitivity and Specificity Klebsiella pneumoniae Klebsiella Infections Bacterial Proteins Humans Machine Learning
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