AI Medical Compendium Topic

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Limit of Detection

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Deep learning networks find unique mammographic differences in previous negative mammograms between interval and screen-detected cancers: a case-case study.

Cancer imaging : the official publication of the International Cancer Imaging Society
BACKGROUND: To determine if mammographic features from deep learning networks can be applied in breast cancer to identify groups at interval invasive cancer risk due to masking beyond using traditional breast density measures.

Electrochemical inhibition bacterial sensor array for detection of water pollutants: artificial neural network (ANN) approach.

Analytical and bioanalytical chemistry
This work reports on further development of an inhibition electrochemical sensor array based on immobilized bacteria for the preliminary detection of a wide range of organic and inorganic pollutants, such as heavy metal salts (HgCl, PbCl, CdCl), pest...

Automated online coupling of robot-assisted single drop microextraction and liquid chromatography.

Journal of chromatography. A
A high-throughput and innovative setup has been developed to automate the online integration of single drop microextraction (SDME), liquid chromatography (LC) and high-resolution mass spectrometry (QqToF). SDME and LC were online hyphenated for the f...

Ultrasensitive sandwich-type immunosensor for cardiac troponin I based on enhanced electrocatalytic reduction of HO using β-cyclodextrins functionalized 3D porous graphene-supported Pd@Au nanocubes.

Journal of materials chemistry. B
In this study, Pd@Au nanocubes supported β-cyclodextrins functionalized three-dimensional porous graphene (CDs-3D-PG-Pd@Au NCs) was synthesized using a facile method. β-cyclodextrins (CDs) were beneficial in improving the dispersibility of three-dime...

Development and validation of a sensitive method for alkyl sulfonate genotoxic impurities determination in drug substances using gas chromatography coupled to triple quadrupole mass spectrometry.

Journal of pharmaceutical and biomedical analysis
Alkyl sulfonate esters have been widely concerned as genotoxic impurities (GTIs). A gas chromatography triple-quadrupole mass spectrometry (GC-MS/MS) method has been developed for trace determination of 9 commonly encountered sulfonate esters in drug...

Molecularly imprinted polymer based quartz crystal microbalance sensor for the clinical detection of insulin.

Materials science & engineering. C, Materials for biological applications
In this study, quartz crystal microbalance sensors based on molecular imprinting technology were fabricated for real-time detection of insulin in aqueous solution and artificial plasma. This study describes the preparation of insulin imprinted poly(h...

Employing AgNPs doped amidoxime-modified polyacrylonitrile (PAN-oxime) nanofibers for target induced strand displacement-based electrochemical aptasensing of CA125 in ovarian cancer patients.

Materials science & engineering. C, Materials for biological applications
In this study, a high-performance biosensing nanoplatform based on amidoxime-modified polyacrylonitrile nanofibers decorated with Ag nanoparticles (AgNPs-PAN-oxime NFs) is described. The AgNPs-PAN-oxime NFs were prepared by the combination of electro...

Focusing aptamer selection on the glycan structure of prostate-specific antigen: Toward more specific detection of prostate cancer.

Biosensors & bioelectronics
The development of chemical sensors capable of detecting the specific glycosylation patterns of proteins offers a powerful mean for the early detection of cancer. Unfortunately, this strategy is scarcely explored because receptors recognizing the gly...

A smartphone-based system for fluorescence polarization assays.

Biosensors & bioelectronics
This paper demonstrates the use of a smartphone-based sensor for fluorescence polarization (FP) analysis of biomolecules. The FP detection can rapidly sense ligand-analyte bindings by measuring molecule mobility, and thus, FP-based assays have been w...

Smartphone-based fluorescent lateral flow immunoassay platform for highly sensitive point-of-care detection of Zika virus nonstructural protein 1.

Analytica chimica acta
Simple, inexpensive, and rapid diagnostic tests in low-resource settings with limited laboratory equipment and technical expertise are instrumental in reducing morbidity and mortality from epidemic infectious diseases. We developed a smartphone-based...